Craniofacial reconstruction with bone and biomaterials: Review over the last 11 years

Neovius, Erik; Engstrand, Thomas

doi:10.1016/j.bjps.2009.06.003

Cited by 215 publications

(175 citation statements)

References 83 publications

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“…This would allow for better results in terms of contour and symmetry, which are of vital importance in craniofacial reconstruction and a drawback of traditional methods. Besides, complications such as postoperative implant displacement, infections and implant exposure could be potentially reduced 6 . On other advantage would be the reduction of operative time, since time consuming intraoperative modeling would not be necessary 17 .…”

Section: Discussionmentioning

confidence: 99%

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Paired evaluation of calvarial reconstruction with prototyped titanium implants with and without ceramic coating

et al. 2014

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PURPOSE:To investigate the osseointegration properties of prototyped implants with tridimensionally interconnected pores made of the Ti 6 Al 4 V alloy and the influence of a thin calcium phosphate coating. METHODS:Bilateral critical size calvarial defects were created in thirty Wistar rats and filled with coated and uncoated implants in a randomized fashion. The animals were kept for 15, 45 and 90 days. Implant mechanical integration was evaluated with a push-out test.Bone-implant interface was analyzed using scanning electron microscopy. RESULTS:The maximum force to produce initial displacement of the implants increased during the study period, reaching values around 100N for both types of implants. Intimate contact between bone and implant was present, with progressive bone growth into the pores. No significant differences were seen between coated and uncoated implants. CONCLUSION:Adequate osseointegration can be achieved in calvarial reconstructions using prototyped Ti 6 Al 4 V Implants with the described characteristics of surface and porosity.

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Section: Discussionmentioning

confidence: 99%

“…Their biocompatibility has been extensively demonstrated, especially related to bone, both experimentally [2][3][4][5] and clinically [6][7][8][9] with variable implant designs and methods of construction.…”

Section: Introductionmentioning

confidence: 99%

Paired evaluation of calvarial reconstruction with prototyped titanium implants with and without ceramic coating

et al. 2014

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“…This will ensure that mechanical stability and metabolic function are maintained at the defect site and minimise the risk of failure from infection [2,3]. Over recent years, an increasing number of synthetic bone substitutes have become clinically available as alternatives to traditional graft materials [4,5]. Despite this, clinicians preferentially choose autologous bone graft, as synthetic alternatives still fail to match their in vivo performance [6,7].…”

Section: Introductionmentioning

confidence: 99%

An in vitro Study to Assess the Potential of a Unique Micro porous Algal Derived Cap Bone Void Filler in Comparison with Clinically-Used Bone Void Fillers

Walsh¹

2011

J Tissue Sci Eng

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“…However, the primary treatment and closure of large-area bone defects continues to face major technical challenges. The gold standard for craniomaxillofacial (CMF) reconstruction, segmental bone defects, and spine fusion is currently autograft transplantation, which is hampered by the limited supply of donor bone and the potential for considerable donor site morbidity associated with the tissue harvest (2). There is a compelling need for an off-the-shelf device to manage many types of bone defects.…”

mentioning

confidence: 99%

Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction

Shah

Hyder

Quadir

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

131

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Traumatic wounds and congenital defects that require large-scale bone tissue repair have few successful clinical therapies, particularly for craniomaxillofacial defects. Although bioactive materials have demonstrated alternative approaches to tissue repair, an optimized materials system for reproducible, safe, and targeted repair remains elusive. We hypothesized that controlled, rapid bone formation in large, critical-size defects could be induced by simultaneously delivering multiple biological growth factors to the site of the wound. Here, we report an approach for bone repair using a polyelectrolye multilayer coating carrying as little as 200 ng of bone morphogenetic protein-2 and platelet-derived growth factor-BB that were eluted over readily adapted time scales to induce rapid bone repair. Based on electrostatic interactions between the polymer multilayers and growth factors alone, we sustained mitogenic and osteogenic signals with these growth factors in an easily tunable and controlled manner to direct endogenous cell function. To prove the role of this adaptive release system, we applied the polyelectrolyte coating on a well-studied biodegradable poly(lactic-co-glycolic acid) support membrane. The released growth factors directed cellular processes to induce bone repair in a critical-size rat calvaria model. The released growth factors promoted local bone formation that bridged a critical-size defect in the calvaria as early as 2 wk after implantation. Mature, mechanically competent bone regenerated the native calvaria form. Such an approach could be clinically useful and has significant benefits as a synthetic, off-the-shelf, cell-free option for bone tissue repair and restoration.regenerative medicine | layer-by-layer | biomaterial | controlled drug release | wound healing

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Craniofacial reconstruction with bone and biomaterials: Review over the last 11 years

Cited by 215 publications

References 83 publications

Paired evaluation of calvarial reconstruction with prototyped titanium implants with and without ceramic coating

Paired evaluation of calvarial reconstruction with prototyped titanium implants with and without ceramic coating

An in vitro Study to Assess the Potential of a Unique Micro porous Algal Derived Cap Bone Void Filler in Comparison with Clinically-Used Bone Void Fillers

Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction

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