Craniofacial resection of a nasoseptal chondrosarcoma: case report and review of the literature

Kaufman, Jenifer; Pritz, Michael B.; Righi, Paul D.; Bizal, John C.

doi:10.1016/s0090-3019(99)00085-3

Cited by 22 publications

(19 citation statements)

References 17 publications

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“…The English literature includes three reports describing four cases of endoscopic removal of nasal septum chondrosarcomas, in all of which clear tumour margins were confirmed by preoperative CT scans and good local control was achieved [1,6,8]. At present, we consider cases without skull-base involvement to be good indications for transnasal endoscopic removal.…”

Section: Discussionmentioning

confidence: 99%

“…These findings point towards open approaches for complete removal. However, in cases of nasal chondrosarcoma, extensive en bloc removal by open approaches, such as lateral rhinotomy, anterior craniofacial resection with or without facial dismasking and Le Fort I down-fracture [5][6][7], is often undesirable because of functional and cosmetic problems and significant associated morbidity. We chose the transnasal endoscopic piece-bypiece removal of the tumour in this case, on the basis of the superior cosmetic and functional results, the low rate of distant metastasis, and the resectable tumour margins.…”

Section: Discussionmentioning

confidence: 99%

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Endoscopic Removal of Chondrosarcoma Originating from the Nasal Septum

Sakamoto¹,

Nakagawa²,

Ito³

2010

TOOTORJ

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Abstract:Background: Chondrosarcomas are rare non-epithelial malignant tumours. Surgery is the primary treatment option for chondrosarcoma, with adjuvant therapy having a minor role. In cases of nasal chondrosarcoma, however, en bloc total removal by open approaches is often undesirable. Here we report a case of chondrosarcoma arising from the nasal septum, which was resected endoscopically.Case Report: The case was 50-year-old man with nasal stuffiness. Computed tomography revealed a large lesion arising from the nasal septum composed of a low-density area with scattered high-density areas. Grade I chondrosarcoma was diagnosed based on histopathological analysis. After tumour margins were carefully identified on CT images and in the nasal cavities, trans-nasal endoscopic piece-by-piece tumour removal was conducted. One year after the surgery, there was no sign of local recurrence or distant metastasis.Clinical Implication: Transnasal endoscopic removal could represent a safe and potentially curative treatment for this malignant tumour.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Endoscopic Removal of Chondrosarcoma Originating from the Nasal Septum

Sakamoto¹,

Nakagawa²,

Ito³

2010

TOOTORJ

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“…The radical surgical resection is the preferred treatment of choice, but unfortunately skull based chondrosarcoma has a strong tendency for local recurrence, mainly due to the complicatedness of complete resection. The effectiveness of adjuvant therapy as irradiation and chemotherapy is still under discussion [1,5]. In vitro experiments showed that chondrosarcoma cells can be destroyed by antigen specific lymphocytes and these results suggest that immunotherapy directed against chondrosarcoma cells is possible [5,15].…”

Section: Discussionmentioning

confidence: 99%

“…Chondrosarcoma constitute nearly 8% of primary bone tumors overall and 10% of them are diagnosed in the head and neck region [1]. This type of neoplasm may arise from cartilage, mesenchymal cells or embryonal rests.…”

Section: Introductionmentioning

confidence: 99%

Dendritic cells based immunotherapy of patient with chondrosarcoma--case report.

Tabarkiewicz

Radej²,

Hus³

et al. 2008

Folia Histochem Cytobiol.

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Abstract:We present a case report of patient with intracranial chondrosarcoma and attempt to use vaccination of dendritic cells as the salvage therapy. To our knowledge, this is the first case report of DCs vaccination in the head and neck chondrosarcoma. Immunotherapy with allogeneic DCs stimulated with tumor cell lysates in this case was demonstrated to be feasible, safe and well tolerated. Unfortunately we did not observe any clinical or immune response during vaccination. CD4+ and CD8+ regulatory cells could be responsible for ineffectiveness of immunotherapy.

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“…Le chondrosarcome représente la seconde tumeur osseuse maligne primitive de l'homme [3]. Il constitue 0,1 % de toutes les tumeurs de la tête et du cou [4].…”

Section: Aspects éPidémiologiquesunclassified

Chondrosarcome mandibulaire: à propos d’un cas et revue de la littérature

et al. 2010

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Les chondrosarcomes sont des tumeurs cartilagineuses malignes à localisation maxillaire rare. Ils sont caractérisés par une évolution généralement lente dans le temps et par une tendance élevée aux récidives locorégionales après traitement chirurgical. Leur pronostic médiocre dépend de leur degré de différenciation et de la qualité de résection. Les auteurs rapportent un cas clinique de chondrosarcome mandibulaire et précisent les particularités épidémio-logiques, diagnostiques, thérapeutiques et évolutives de ces tumeurs. Mots clés Chondrosarcome · Mandibule · Tumeur cartilagineuseAbstract Chondrosarcoma is a malignant cartilaginous tumor rarely found in the jaw bone. Tumor progression is slow with strong propensity to recurrence after surgical removal. The prognosis is poor and depends on the degree of differentiation and the quality of resection. We report a case of mandibular chondrosarcoma and discuss the epidemiology, diagnosis, treatment, and follow-up of these tumors.

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Craniofacial resection of a nasoseptal chondrosarcoma: case report and review of the literature

Cited by 22 publications

References 17 publications

Endoscopic Removal of Chondrosarcoma Originating from the Nasal Septum

Endoscopic Removal of Chondrosarcoma Originating from the Nasal Septum

Dendritic cells based immunotherapy of patient with chondrosarcoma--case report.

Chondrosarcome mandibulaire: à propos d’un cas et revue de la littérature

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