Craniotomy for acute monitoring of pial vessels in the rodent brain

Aboghazleh, Refat; Alkahmous, Baraah; Swissa, Evyatar; Mansoor, Saara; Friedman, Alon; Prager, Ofer

doi:10.1016/j.mex.2022.101694

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Sds and Neurovascular Coupling1

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2022

2024

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Cited by 4 publications

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“…Furthermore, during SD, glucose and energy consumption are increased three times, tissue ATP abundance falls, and the extracellular concentration of sodium, chloride, and calcium ions are decreased [120][121][122] . Although there is an increase in rCBF during the early phase of SD to supply the tissue with the energy necessary to restore ionic equilibrium 54 , but tissue hypoxia still can be detected in brain regions that are away from capillary supply 123,124 . A rodent study monitored the blood flow in cortical cerebral vessels, and hyperemia during SDs was obvious in small vessels and to less extent in arterioles and venules 111 .…”

Section: Sds and Neurovascular Couplingmentioning

confidence: 99%

Spreading depolarization: A phenomenon in the brain

Aboghazleh

Alkahmous

Turan³

et al. 2022

Archives Italiennes De Biologie

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Spreading depolarizations is a generic term for the spectrum of waves initiated and propagated in the central nervous system (CNS), characterized by abrupt and near-complete sustained neuronal depolarization 1,4 , observed as a large slow potential change in the extracellular space 5,6 and propagate at 1-9.5 mm/min across the brain 7,8 . During SDs, neurons cannot fire action potentials, as the sustained depolarization is above the threshold, and the

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