Creams Formulated with Ocimum gratissimum L. and Lantana camara L. Crude Extracts and Fractions as Mosquito Repellents Against Aedes aegypti L. (Diptera: Culicidae)

Keziah, Ezeike Amarachi; Nukenine, Elias Nchiwan; Danga, Simon Pierre Yinyang; Younoussa, Lame; Esimone, Charles Okechukwu

doi:10.1093/jisesa/iev025

Cited by 26 publications

(18 citation statements)

References 14 publications

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“…Treatments were performed in cages (30 × 30 cm) made of white cotton cloth with two openings (15 cm diameter) on either side. The extract was formulated as previously described [51], and DEET (N,N-diethyl-3-methylbenzamide) was taken as a positive control. Hands were entirely covered with three layers of latex gloves.…”

Section: Bioassaymentioning

confidence: 99%

Larvicidal, Ovicidal, Synergistic, and Repellent Activities of Sophora alopecuroides and Its Dominant Constituents Against Aedes albopictus

Shoukat

Shakeel

Rizvi

et al. 2020

Insects

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In the current study, to combat insecticide resistance, we explored larvicidal, ovicidal, synergistic, and repellent activities of Sophora alopecuroides extract and its dominant constituents against Aedes albopictus. The results of the toxicity bioassays demonstrated that the extract of S. alopecuroides exerted significant larvicidal activity (16.66-86.66%) against the third-instar larvae of Ae. albopictus at different concentrations (5-50 ug/mL) and low hatchability of eggs (2.32-75%) at 5-50 ug/mL. The constituents of S. alopecuroides showed a synergistic effect when applied as a mixture (LC 30 + LC 30 ) against larvae, while no synergistic effect was observed against the eggs of Ae. albopictus. S. alopecuroides extract provided 93.11% repellency in the first 90 min and gradually decreased to 53.14% after 240 min, while the positive control DEET (N,N-diethyl-3-methylbenzamide) showed 94.18% in the first 90 min and 55.33% after 240 min. All of the results exhibited a concentration-dependent effect. To the best of our knowledge, this is the first time that a study has identified a highly effective extract of S. alopecuroides, which could be used as an alternative agent to control larvae and eggs and to repel adults of Ae. albopictus.

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Section: Bioassaymentioning

confidence: 99%

Larvicidal, Ovicidal, Synergistic, and Repellent Activities of Sophora alopecuroides and Its Dominant Constituents Against Aedes albopictus

Shoukat

Shakeel

Rizvi

et al. 2020

Insects

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“…This indicates that the P. aduncum EO in semisolid formulations is as effective as the synthetic repellent PMD at repelling mosquitoes since the EO could repel >80% of the mosquitoes for more than 2 h. All the semisolid formulations were able to repel >65% of the mosquitoes 4 h post-application. In contrast, a recent study showed that a cream formulation containing Lantana camara Linnaeus methanol crude extracts and hexane and ethyl acetate fractions could only repel >60% of the mosquitoes up to 2.5 h post-application (Keziah et al , 2015).…”

Section: Discussionmentioning

confidence: 95%

The formulation of the essential oil ofPiper aduncumLinnaeus (Piperales: Piperaceae) increases its efficacy as an insect repellent

Mamood

Hidayatulfathi

Budin

et al. 2016

Bull. Entomol. Res.

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The essential oil (EO) of Piper aduncum Linnaeus, known as 'sireh lada' to locals Malaysian, has the potential to be used as an alternative to synthetic insect repellents such as N,N-diethyl-meta-toluamide. However, the EO's efficacy as a repellent decreases after application due to the high volatility of its active ingredients. A number of studies have showed that optimizing the formulation of plant-based EOs can improve their efficacy as repellents. The present study sought to evaluate the effectiveness of 10% P. aduncum EO in ethanol and in three different semisolid formulations: ointment, cream and gel. These formulations were tested on Aedes aegypti under laboratory conditions. Each formulation was applied to the subject's hands, which were then inserted into a cage containing 25 nulliparous A. aegypti. The number of mosquitoes landing on or biting each subject's hand was recorded, and the repellency percentage, landing/biting percentage and protection time for each of the formulations were compared. There were no statistically significant differences between the semisolid EO formulations with regards to the repellency percentage and the landing/biting percentage at 4 h post-application. All three semisolid EO formulations were able to repel >65% of the A. aegypti at 4 h post-application. The EO ointment formulation provided a protection time (182.5 ± 16.01 min) that was statistically significantly longer than that associated with the EO gel formulation (97.5 ± 14.93 min). Meanwhile, the EO cream formulation provided a protection time of 162.5 ± 6.29 min. As the EO cream and ointment formulations displayed better repellent properties than the EO gel formulation, they appear to be the most promising P. aduncum EO formulations to be developed and commercialized as alternatives to synthetic repellents.

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“…The repellent effects were based on the strength of the extracts and fractions. Methanol crude extracts combination and hexane fractions mixtures from both plants showed synergistic effect [60].…”

Section: Antiparasitic Effectsmentioning

confidence: 99%

Chemical Constituents and Pharmacological Activities of Lantana Camara – A Review

Al-Snafi

2019

Asian J Pharm Clin Res

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Objective: The review was designed to investigate the traditional uses, chemical constituents and pharmacological effects of Lantana camara. Methods: In the current review, databases including Web Science, Pub Med, Scopus and Science Direct, were searched to investigate the chemical constituents and pharmacological effects of Lantana camara. Results: The plant contained alkaloids, glycosides, steroids, saponins, flavanoids, coumarins, tannins, carbohydrates, hydroxy anthraquinones, anthraquinone glycosides, proteins, phytosteroids, fixed oils, fats, and triterpinoids. Previous pharmacological studies revealed that Lantana camara possessed antimicrobial, antiparasitic, anxiolytic, gastrointestinal, hypoglycemic, cardiovascular, antioxidant, anticancer, antiinflammatory, analgesic, wound healing, antiurolithiatic, hepatoprotective, reproductive, anti–hemorrhoidal, thrombin inhibition and many other effects. Conclusion: Lantana camara represents a promising medicinal plant with a wide range of pharmacological activities that could be utilized in several medical applications because of its effectiveness and safety.

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Creams Formulated with Ocimum gratissimum L. and Lantana camara L. Crude Extracts and Fractions as Mosquito Repellents Against Aedes aegypti L. (Diptera: Culicidae)

Cited by 26 publications

References 14 publications

Larvicidal, Ovicidal, Synergistic, and Repellent Activities of Sophora alopecuroides and Its Dominant Constituents Against Aedes albopictus

Larvicidal, Ovicidal, Synergistic, and Repellent Activities of Sophora alopecuroides and Its Dominant Constituents Against Aedes albopictus

The formulation of the essential oil ofPiper aduncumLinnaeus (Piperales: Piperaceae) increases its efficacy as an insect repellent

Chemical Constituents and Pharmacological Activities of Lantana Camara – A Review

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