Creatine Kinase and Lactate Dehydrogenase Responses After Different Resistance and Aerobic Exercise Protocols

Abstract

The aim of this study was to investigate the responses of creatine kinase (CK) and lactate dehydrogenase (LDH) after performing different resistance and aerobic exercise protocols. Twelve recreationally trained men (age, 23.2 ± 5.6 years; body mass, 84.3 ± 9.3 kg; body height, 178.9 ± 4.5 cm; and BMI, 26.3 ± 2.3 kg·m2) volunteered to participate in this study. All subjects were randomly assigned to four experimental protocols (crossover): (a) aerobic training at 60% of VO2max, (b) aerobic training at 80% of VO2max, (c) a resistance exercise (RE) session with a bi-set protocol, and (d) an RE session with a multiple sets protocol. Blood samples were collected before, immediately after and 24 hours following the experimental protocols. After 24 hours, there was a significant increase in CK for the 80% of VO2max protocol vs. the bi-set RE session (p = 0.016). Immediately after the protocols, we observed a significant increase in LDH among certain groups compared to others, as follows: multiple sets RE session vs. 60% of VO2max, bi-set RE session vs. 60% of VO2max, multiple sets RE session vs. 80% of VO2max, and bi-set RE session vs. 80% of VO2max (p = 0.008, p = 0.013; p = 0.002, p = 0.004, respectively). In conclusion, aerobic exercise performed at 80% of VO2max appears to elevate plasma CK levels more than bi-set RE sessions. However, the bi-set and multiple sets RE sessions appeared to trigger greater levels of blood LDH compared to aerobic protocols performed at 60% and 80% of VO2max.

Effect of short-term physical exercise on serum markers of skeletal muscle damage in hypertensive patients treated with a combination of statin and angiotensin-converting enzyme inhibitor

“…We have also looked at the post-exercise changes of muscle damage markers and we found a small non-significant numerical increase in these markers during the recovery from exercise. Even small changes in creatine kinase activity during exercise seem to confirm the effect of exercise on the integrity of muscle cells, which is consistent with earlier studies performed by other authors but in different populations and different experimental conditions [30,31].…”

Specialized Movement on the Rowing Ergometer and Post-workout Changes in Selected Peripheral Blood Parameters - a Case Report.

“…This clinical variable could be good diagnostic marker for the evaluation of physical fitness and condition of athletes as well (Nowak, Buryta, Kostrzewa-Nowak, 2016). P. Proia, A. Amato, V. Contró, D. Thiel, P. Vostatková, B. Buryta, M. Kolbowicz, T. Lewandowski, A. Nowakowska CK is frequently described as the best indirect marker of damage of muscle tissue, especially after resistance exercise (Callegari et al, 2017). In our investigation, CK and LDH activity were at the very high levels in the postexercise period of time, considerably exceeding the reference values established for general population.…”

The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study

“…There was no change in the other biomarkers of muscle damage (lactate dehydrogenase) or inflammation (high sensitivity C-reactive protein and interleukin-10 and 6) following the leg press exercise. The responses of lactate dehydrogenase [21,22], C-reactive protein [23], and interleukin-10 [24] to resistance exercise are variable. Interleukin-6 usually increases after resistance exercise, but it may be that the volume of the leg press exercise was too little to see any changes in this biomarker [23].…”