Creatine Kinase Revisited

Katiriji, B; Jaberi, M M Al

doi:10.1097/00131402-200103000-00008

Cited by 32 publications

(25 citation statements)

References 50 publications

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“…During that outbreak, immunohistochemical staining revealed no viral antigen except in samples of neurons, neuronal processes, and areas of necrosis in the gray matter [14]. Motor neuron disease, including acute poliomyelitis, and acute axonal neuropathies can be associated with mild-to-moderate elevations of CK levels [16][17][18][19][20].…”

Section: Recent Electrophysiological and Histopathological Reports Pomentioning

confidence: 99%

Histopathologically Proven Poliomyelitis with Quadriplegia and Loss of Brainstem Function Due to West Nile Virus Infection

Doron

Dashe

Adelman

et al. 2003

Clinical Infectious Diseases

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Section: Recent Electrophysiological and Histopathological Reports Pomentioning

confidence: 99%

Histopathologically Proven Poliomyelitis with Quadriplegia and Loss of Brainstem Function Due to West Nile Virus Infection

Doron

Dashe

Adelman

et al. 2003

Clinical Infectious Diseases

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“…Transient or persistent serum CK elevation (normal values in our laboratory 24-195 U/ L) can be related to many other diseases or physiological and paraphysiological conditions [6,10,16,20]. Chronic elevation of serum CK activity is occasionally found in apparently healthy individuals [8]. In 1980 Rowland et al coined the term ''idiopathic hyperCKemia'' for cases with no clinical, neurophysiological and histopathological evidence of neuromuscular disease [18].…”

Section: Introductionmentioning

confidence: 99%

Follow-up of a large population of asymptomatic/oligosymptomatic hyperckemic subjects

et al. 2006

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Six years before the present study we performed a retrospective study of 114 subjects presenting with asymptomatic / oligosymptomatic hyperckemia (raised creatine kinase blood levels), a diagnosis being made in 21 of them. We now present the results of a long-term follow-up in 55 of the still undiagnosed 93 individuals. Most of them have remained asymptomatic and did not develop specific neuromuscular disorders. One subject became frankly symptomatic manifesting limb-girdle weakness. A diagnosis of dystrophinopathy carrier and one of possible type I SMA carrier were indirectly made in another two subjects. Almost all subjects still have hyperckemia, though the mean creatine kinase (CK) value is lower than before. CK levels have become normal in 12 subjects. Two died of neoplasia, and six developed non-neuromuscular disorders. We noted no follow-up differences in terms of CK modifications between subjects with pathological EMG and/or muscle biopsy findings and those with normal findings at first examination.

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“…Pode-se observar elevação a partir de oito horas após a prática de um exercício vigoroso. Além disso, também se observa elevação entre o segundo e sétimo dia após exercícios excêntricos, associando a elevação à lesão muscular [19,20]. Outro estudo com ciclistas não treinados mostrou aumento significativo de CK após 90 minutos de exercício, sendo que o aumento continuou ocorrendo até o terceiro dia de exercício [21].…”

Section: /7unclassified

“…Em geral, elevações maiores das concentrações de CK podem ser identificadas precocemente, permanecendo por maior intervalo de tempo. Geralmente os níveis de CK elevam-se em poucas horas após o exercício, atingindo um pico entre 24 horas e quatro dias, começando a diminuir a partir do terceiro dia [19,20].…”

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Verificação do dano muscular através da avaliação da concentração de creatina quinase em indivíduos não atletas após prova de ciclismo não competitivo

Schneider¹,

Périco²,

Pozzobon

2015

Sci Med

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RESUMOObjetivos: Investigar os níveis séricos da enzima creatina quinase em ciclistas não profissionais após uma prova de ciclismo não competitivo de 300 km, para avaliação de dano muscular. Métodos: Participaram do estudo 12 ciclistas do sexo masculino, com as seguintes médias para os parâmetros antropométricos: idade 38,1±11,5 anos, estatura 1,77±7,7 cm, peso 77±8,5 kg, percentual de gordura 12,0±4,1% e índice de massa corporal 24,7±2,6 kg/m². Os níveis séricos de creatina quinase foram avaliados antes e imediatamente após a prova, através de método cinético. Resultados: O estudo demonstrou que após a prova de 300 km houve uma elevação média de 480% nos níveis séricos de creatina quinase (p<0,0001). Nenhuma correlação foi encontrada entre os níveis de creatina quinase e o índice de massa corporal ou o tempo de prova. Conclusões: Estes dados demonstram elevação nos níveis séricos de creatina quinase após uma prova de ciclismo não competitivo de 300 km, sugerindo a presença de dano muscular nessa modalidade de ciclismo. DESCRITORES: creatina quinase; exercício; músculo; ciclismo. ABSTRACT Aims:To investigate the serum levels of the enzyme creatine kinase in non-professional cyclists after a non-competitive cycling race of 300 km, for evaluation of muscle damage. Methods: The study included 12 male cyclists, with the following means for the anthropometric parameters: age 38.1±11.5 years, height 1.77±7.7 cm, weight 77±8.5 kg, fat percentage 12.0±4.1%, and body mass index 24.7±2.6 kg/m². Serum levels of creatine kinase were assessed before and immediately after the race, through kinetic method. Results: The study showed that after the 300 km race there was an average increase of 480% in serum levels of creatine kinase (p<0.0001). No correlation was found between creatine kinase levels and body mass index or time of race. Conclusions: These data show increase in serum levels of creatine kinase after a non-competitive cycling race of 300 km, suggesting the presence of muscle damage in this cycling mode.KEY WORDS: creatine kinase; exercise; muscle; cycling. Scientia Medica Artigo originAlOpen Access

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Creatine Kinase Revisited

Cited by 32 publications

References 50 publications

Histopathologically Proven Poliomyelitis with Quadriplegia and Loss of Brainstem Function Due to West Nile Virus Infection

Histopathologically Proven Poliomyelitis with Quadriplegia and Loss of Brainstem Function Due to West Nile Virus Infection

Follow-up of a large population of asymptomatic/oligosymptomatic hyperckemic subjects

Verificação do dano muscular através da avaliação da concentração de creatina quinase em indivíduos não atletas após prova de ciclismo não competitivo

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