Creatine or vitamin D supplementation in individuals with a spinal cord injury undergoing resistance training: A double-blinded, randomized pilot trial

Amorim, Samuel; Teixeira, Vítor Hugo; Corredeira, Rui; Cunha, Maria Rosária; Maia, Bruno; Margalho, Paulo; Pires, Joana

doi:10.1080/10790268.2017.1372058

Cited by 18 publications

(20 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In subjects with spinal cord injury, Cr levels improve muscle strength parameters, and this has a positive effect on the performance of daily activities and body health [37]. In Paralympic weightlifting athletes, who have suffered spinal cord injury, creatine can help to maximize the performance of the upper limbs by reducing the FI and providing a faster recovery during the practices provided by the sport [38].…”

Section: Discussionmentioning

confidence: 99%

Can Creatine Supplementation Interfere with Muscle Strength and Fatigue in Brazilian National Level Paralympic Powerlifting?

et al. 2020

View full text Add to dashboard Cite

The aim of the present study was to analyze the effect of creatine (Cr) supplementation on peak torque (PT) and fatigue rate in Paralympic weightlifting athletes. Eight Paralympic powerlifting athletes participated in the study, with 25.40 ± 3.30 years and 70.30 ± 12.15 kg. The measurements of muscle strength, fatigue index (FI), peak torque (PT), force (kgf), force (N), rate of force development (RFD), and time to maximum isometric force (time) were determined by a Musclelab load cell. The study was performed in a single-blind manner, with subjects conducting the experiments first with placebo supplementation and then, following a 7-day washout period, beginning the same protocol with creatine supplementation for 7 days. This sequence was chosen because of the lengthy washout of creatine. Regarding the comparison between conditions, Cr supplementation did not show effects on the variables of muscle force, peak torque, RFD, and time to maximum isometric force (p > 0.05). However, when comparing the results of the moments with the use of Cr and placebo, a difference was observed for the FI after seven days (U3: 1.12; 95% CI: (0.03, 2.27); p = 0.02); therefore, the FI was higher for placebo. Creatine supplementation has a positive effect on the performance of Paralympic powerlifting athletes, reducing fatigue index, and keeping the force levels as well as PT.

show abstract

Section: Discussionmentioning

confidence: 99%

Can Creatine Supplementation Interfere with Muscle Strength and Fatigue in Brazilian National Level Paralympic Powerlifting?

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Several studies have also evaluated the impact of creatine supplementation on mild traumatic brain injury (TBI) and spinal cord injury (SCI) outcomes in animals [ 3 , 6 , 171 , 262 , 263 , 264 , 265 , 266 ]. For example, Sullivan and coworkers [ 264 ] found that provision of creatine in the diet for 5 days prior to TBI decreased the amount of cortical brain damage by 36% in rats and 50% in mice.…”

Section: Potential Therapeutic Role Of Creatine Supplementationmentioning

confidence: 99%

“…For example, Jacobs et al [ 268 ] reported that creatine supplementation (20 g/day for 7 days) enhanced aerobic exercise capacity and ventilatory anaerobic threshold in patients with cervical SCI. Moreover, Amorim et al [ 266 ] reported that individuals with SCI who consumed creatine (3 g/day for 8 weeks) with vitamin D (25,000 IU/day) while participating in a resistance-training program experienced significantly greater improvements in arm muscle area, strength, and functional capacity. While some studies report no benefit of creatine supplementation in patients with SCI [ 269 , 270 ], there is compelling evidence that creatine supplementation may reduce the severity of mild concussions, TBI, and/or SCI in animal models [ 21 , 263 ].…”

Section: Potential Therapeutic Role Of Creatine Supplementationmentioning

confidence: 99%

Creatine in Health and Disease

2021

View full text Add to dashboard Cite

Although creatine has been mostly studied as an ergogenic aid for exercise, training, and sport, several health and potential therapeutic benefits have been reported. This is because creatine plays a critical role in cellular metabolism, particularly during metabolically stressed states, and limitations in the ability to transport and/or store creatine can impair metabolism. Moreover, increasing availability of creatine in tissue may enhance cellular metabolism and thereby lessen the severity of injury and/or disease conditions, particularly when oxygen availability is compromised. This systematic review assesses the peer-reviewed scientific and medical evidence related to creatine’s role in promoting general health as we age and how creatine supplementation has been used as a nutritional strategy to help individuals recover from injury and/or manage chronic disease. Additionally, it provides reasonable conclusions about the role of creatine on health and disease based on current scientific evidence. Based on this analysis, it can be concluded that creatine supplementation has several health and therapeutic benefits throughout the lifespan.

show abstract

“…Supplementation with creatine to improve muscle strength in patients with chronic SCI has been also evaluated, with conflicting results. Two studies found no effect of creatine supplementation either on hand strength (78) or wheelchair performance (79), while two studies found some positive effects on upper extremity strength and function (80,81). All these diverse correlations highlight the need for a prompt and precise nutritional assessment in SCI patients, focusing on correct daily energy intake and a higher fiber and micronutrient intake (i.e., vitamin D and calcium).…”

Section: Nutritional Interventionsmentioning

confidence: 99%

Spinal Cord Injury as a Model of Bone-Muscle Interactions: Therapeutic Implications From in vitro and in vivo Studies

et al. 2020

View full text Add to dashboard Cite

Spinal cord injuries (SCIs) represent a variety of conditions related to the damage of the spinal cord with consequent musculoskeletal repercussions. The bone and muscle tissues share several catabolic pathways that lead to variable degrees of disability in SCI patients. In this review article, we provide a comprehensive characterization of the available treatment options targeting the skeleton and the bone in the setting of SCI. Among the pharmacological intervention, bisphosphonates, anti-sclerostin monoclonal antibodies, hydrogen sulfide, parathyroid hormone, and RANKL pathway inhibitors represent valuable options for treating bone alterations. Loss phenomena at the level of the muscle can be counteracted with testosterone, anabolic-androgenic steroids, and selective androgen receptor modulators. Exercise and physical therapy are valuable strategies to increase bone and muscle mass. Nutritional interventions could enhance SCI treatment, particularly in the setting of synergistic and multidisciplinary interventions, but there are no specific guidelines available to date. The development of multidisciplinary recommendations is required for a proper clinical management of SCI patients.

show abstract

Creatine or vitamin D supplementation in individuals with a spinal cord injury undergoing resistance training: A double-blinded, randomized pilot trial

Abstract: Supplementation with creatine may improve muscle strength parameters in individuals with spinal cord injury. Vitamin D deficiency is highly prevalent in this population. It is recommended an initial screening of vitamin D levels at the beginning of the physical rehabilitation process.

Cited by 18 publications

References 45 publications

Can Creatine Supplementation Interfere with Muscle Strength and Fatigue in Brazilian National Level Paralympic Powerlifting?

Can Creatine Supplementation Interfere with Muscle Strength and Fatigue in Brazilian National Level Paralympic Powerlifting?

Creatine in Health and Disease

Spinal Cord Injury as a Model of Bone-Muscle Interactions: Therapeutic Implications From in vitro and in vivo Studies

Contact Info

Product

Resources

About