Creatinuria and Dynamics of Calcium Metabolism in Children in the Phase of Exacerbation of Bronchial Asthma

Abstract

: Bronchial asthma is one of the most common and severe disease among children. The phenomenon of creatinuria (CU) in patients with bronchial asthma (BA) has been acknowledged for relatively long time. : Aim of the research is to study the level of creatinuria, creatinemia, creatine kinase activity and the concentration of calcium in biological medium (blood, saliva, urine) in children suffering from intermittent and persistent form of asthma during the period of exacerbation. Material and methods:: The research consists of 102 children’s with asthma who were treated in inpatient department in Simferopol Clinic. The intermittent course of asthma was recorded in 49 children and persistent course of asthma was recorded in 53 children. The subject of study was blood serum and daily urine of observed patients. The level of calcium in the biological medium was studied using the "Filisit" test kit (Dnipropetrovsk) and the activity of the creatine kinase by test set "Lahma". The levels of creatine and creatinine were determined using a calorimetric method based on a color reaction with picric acid. Results and conclusion: : The analysis testifies that creatinuria in children with persistent BA is caused by the disorder of the phosphorylation process rather than the disorder of creatinin rephospholiration synthesis, that is testified by the normal creatinin level. In children with persistent BA, there is а decrease of creatinin concentration in the blood serum and urine during the exacerbation period and early post exacerbation period. The low activity of creatinin kinase at the background of creatinine elimination is typical for the children in the phase of exacerbation of persistent form of BA, though its level remains to be sufficient for the synthesis of the necessary amount of creatinin phosphate. The processes of creatinuria and calciuria in children suffering from persistent form of BA are interdependent, that is testified by the data of correlative analysis. In connection with this it is possible to consider the change of calcium homeostasis in pathogenesis of the disease as one of the causes of distributing the creatinin metabolism on the cellular level.

Characteristics of calcium homeostasis in patients with different degrees of arterial hypertension

“…In particular, an increase in the intracellular concentration of Ca2+ in patients with hypertension stimulates a reduction in the smooth muscle of arterioles, the secretion of catecholamines by the adrenal glands, and an increase in the sensitivity of peripheral tissue cells to hormonal and mediator effects. An important pathophysiological role is played by serum calcium in renal and cardiovascular functions [8][9][10].…”