1991
DOI: 10.1016/s0022-5347(17)38478-1
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Creation of a Feline Model of Obstructive Uropathy

Abstract: The aim of this project was to create a reproducible, quantifiable feline model of obstructive uropathy. Seventy-three adult female cats of comparable age were evaluated to obtain the normal control urodynamic data base. Twenty-four cats had a silastic cuff installed around the urethra to induce bladder outlet obstruction, and eight underwent a sham operation. Repeated urodynamic evaluations were performed at predetermined postoperative intervals. The obstructed and normal cats inhibited detrusor contractility… Show more

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Cited by 32 publications
(18 citation statements)
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“…Experimental and clinical studies have demonstrated morphological, contractile, and biochemical changes in the bladder, which are associated with BOO 5, 6, 7, 17, 18, 19. Studies have consistently shown increased detrusor collagen content in animal models of obstruction as well as men with BOO/BPH 6, 7, 9, 10, 11, 16.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Experimental and clinical studies have demonstrated morphological, contractile, and biochemical changes in the bladder, which are associated with BOO 5, 6, 7, 17, 18, 19. Studies have consistently shown increased detrusor collagen content in animal models of obstruction as well as men with BOO/BPH 6, 7, 9, 10, 11, 16.…”
Section: Discussionmentioning
confidence: 99%
“…BOO induces morphophysiological changes in the bladder that may result in bladder dysfunction, including detrusor overactivity (DO), detrusor underactivity, and decreased compliance 6, 7. Men with BOO due to BPH (BOO/BPH) may develop detrusor hypertrophy and hyperplasia and accumulation of connective tissue within the muscle bundles 8, 9.…”
Section: Introductionmentioning
confidence: 99%
“…To better understand the effects of bladder outlet obstruction on bladder structure and function, several animal models have been developed and used for research purposes, including rats, rabbits, guinea pigs, cats, dogs, and pigs (Kato et al, 1988;Levin et al, 1990a;Radzinski et al, 1991;Rohner et al, 1978;Seki et al, 1992;Speakman et al, 1991;Steers and DeGroat, 1988). Rats and rabbits subject to experimental partial bladder obstruction eventually develop pathologic changes in their bladders that closely mimic the pathologic changes found in the bladders of humans with benign prostatic hyperplasia (Levin et al, 1990b.…”
Section: Discussionmentioning
confidence: 99%
“…Bladder instability in animal models has been reliably produced by partial urethral obstruction. Although this technique has been described using various species (Mattiasson and Uvelius, 1982;Malmgren et al, 1987;Kato et al, 1988;Radzinski et al, 1991;Azadzoi et al, 1996), the pig is thought to represent a more appropriate model (Sibley, 1985) than either rat or dog to emulate bladder instability in humans. Pigs are similar to humans with respect to overall size, voiding behavior, and baseline values of cystometric flows and pressures (Speakman et al, 1987;Guan et al, 1994).…”
mentioning
confidence: 99%