CREB-mediated generation and neuronal growth regulates the behavioral improvement of geniposide in diabetes-associated depression mouse model

Sun, Bo; Jia, Xiayan; Yang, Fei; Ren, Guoyong; Wu, Xuemei

doi:10.1016/j.neures.2020.05.003

Cited by 17 publications

(9 citation statements)

References 35 publications

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“…The main active ingredients in this formula, which were measured by HPLC, include geniposide, berberine, palmatine, etc ( YANG et al, 2019 ). These ingredients were found to be effective in treating T2DM through a variety of mechanisms ( Gu et al, 2010 ; Zhang et al, 2010 ; Li et al, 2019a ; Li et al, 2019b ; Mi et al, 2019 ; Sun et al, 2020a ; Sun et al, 2020b ; Wu et al, 2020 ). A series of clinical studies have been carried out on the treatment of T2DM with HLJDD, and promising results have been obtained.…”

Section: Introductionmentioning

confidence: 99%

Effect of Huang-Lian Jie-Du Decoction on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Yang

Liu

et al. 2021

Front. Pharmacol.

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Background: Type 2 diabetes mellitus (T2DM) is a heterogeneous disease characterized by persistent hyperglycemia. Huang-Lian Jie-Du decoction (HLJDD) is a traditional Chinese medicine formula which is widely used in treating T2DM in China. A thorough understanding of current body of evidence is needed.Objective: this study aims to summarize the clinical evidence of HLJDD for T2DM to provide an up-to-date and accurate understanding of this issue for research and clinical practice.Methods: Six databases were searched from inception to June 27, 2020 without language and publication status restrictions and randomized controlled trials about HLJDD on T2DM were included. Two evaluators searched and screened citations independently. Risk of bias was assessed by 2019 version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB2). Risk ratio (RR) with 95% confidence interval (CI) was used as an effect measure for dichotomous outcomes and mean difference (MD) with 95% CI was used for continuous outcomes. Subgroup analyses and sensitivity analyses were carried out.Results: Nine studies including 811 participants were included in this study. The overall risk of bias was high risk. Compared with metformin alone, combination treatment of HLJDD and metformin may result in a reduction in HbA1c, FBG, 2hPG, HOMA-IR and an improved lipid metabolism. Evidence comparing HLJDD and metformin or no intervention or placebo was insufficient. The quality of evidence was low.Conclusions: Current evidence about HLJDD on T2DM is still uncertain and more high-quality studies are needed to firmly establish the clinical efficacy and safety of HLJJD.

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Section: Introductionmentioning

confidence: 99%

Effect of Huang-Lian Jie-Du Decoction on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Yang

Liu

et al. 2021

Front. Pharmacol.

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“…Clinical applications are mostly through peripheral administration. To further explore whether peripheral modulation of the CREB/BDNF signaling pathway can modulate neuropathic pain and anxiodepression, we chose 666–15 (10 mg/kg), a specific inhibitor of CREB by intraperitoneal injection ( Sun B. et al, 2021 ; Figure 8A ). The administration of 666–15 was shown to reverse both mechanical allodynia and thermal hyperalgesia produced by peripheral nerve injury ( Figures 8B,C ).…”

Section: Resultsmentioning

confidence: 99%

“…Meanwhile, the CREB/BDNF pathway and excitatory synapse establishment decreased in the spinal cord. P-CREB, BDNF, and PSD-95 decreased in the ACC, while CREB did not change, so that 666–15 suppresses upward transmission of pain signals in the spinal cord, blocks activation of the CREB/BDNF signaling pathway in the ACC, and prevents the progress of mood disorders ( Sun B. et al, 2021 ). There are still several limitations to our experiments, we only employ synaptic markers to evaluate synapse construction and fail to employ electrophysiological techniques to evaluate functional changes at synapses.…”

Section: Discussionmentioning

confidence: 99%

The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats

Wen

et al. 2022

Front. Mol. Neurosci.

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Neuropathic pain is often accompanied by anxiety and depression-like manifestations. Many studies have shown that alterations in synaptic plasticity in the anterior cingulate cortex (ACC) play a critical role, but the specific underlying mechanisms remain unclear. Previously, we showed that cAMP response element-binding protein (CREB) in the dorsal root ganglion (DRG) acts as a transcription factor contributing to neuropathic pain development. At the same time, brain-derived neurotrophic factor (BDNF), as important targets of CREB, is intricate in neuronal growth, differentiation, as well as the establishment of synaptic plasticity. Here, we found that peripheral nerve injury activated the spinal cord and ACC, and silencing the ACC resulted in significant relief of pain sensitivity, anxiety, and depression in SNI rats. In parallel, the CREB/BDNF pathway was activated in the spinal cord and ACC. Central specific knockdown and peripheral non-specific inhibition of CREB reversed pain sensitivity and anxiodepression induced by peripheral nerve injury. Consequently, we identified cingulate CREB/BDNF as an assuring therapeutic method for treating neuropathic pain as well as related anxiodepression.

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“…GP therapy enhanced the activity of cAMP-response element binding protein (CREB) in the hippocampus tissue in a rat model of diabetes-related depression utilizing a high-fat diet supplemented with corticosterone (CORT), consistent with its pro-neurogenic effect (Sun B et al. 2021 ). In an in vitro model, GP improved neurite outgrowth in cultured Neuro2a cells inhibited by fluoxetine, and the combined treatment of the two raised the number of neurite cells by 3% compared with the fluoxetine group (Mkc et al.…”

Section: Iridoids In Treatment Of Depressionmentioning

confidence: 86%

Therapeutic potential of plant iridoids in depression: a review

Kou

Yang

et al. 2022

Pharmaceutical Biology

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Context Depression is a mental disorder characterized by low mood, reduced interest, impaired cognitive function, and vegetative symptoms such as sleep disturbances or poor appetite. Iridoids are the active constituents in several Chinese classical antidepressant formulae such as Yueju Pill, Zhi-Zi-Hou-Po Decoction, Zhi-Zi-Chi Decoction, and Baihe Dihuang Decoction. Parallel to their wide usages, iridoids are considered potential lead compounds for the treatment of neurological diseases. Objective The review summarizes the therapeutic potential and molecular mechanisms of iridoids in the prevention or treatment of depression and contributes to identifying research gaps in iridoids as potential antidepressant medication. Methods The following key phrases were sought in PubMed, Google Scholar, Web of Science, and China National Knowledge Internet (CNKI) without time limitation to search all relevant articles with in vivo or in vitro experimental studies as comprehensively as possible: (‘iridoid’ or ‘seciridoid’ or ‘depression’). This review extracted the experimental data on the therapeutic potential and molecular mechanism of plant-derived iridoids for depression. Results Plant iridoids (i.e., catalpol, geniposide, loganin), and secoiridoids (i.e., morroniside, gentiopicroside, oleuropein, swertiamarin), all showed significant improvement effects on depression. Discussion and conclusions Iridoids exert antidepressant effects by elevating monoamine neurotransmitters, reducing pro-inflammatory factors, inhibiting hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, increasing brain-derived neurotrophic factor (BDNF) and its receptors, and elevating intestinal microbial abundance. Further detailed studies on the pharmacokinetics, bioavailability, and key molecular targets of iridoids are also required in future research, ultimately to provide improvements to current antidepressant medications.

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CREB-mediated generation and neuronal growth regulates the behavioral improvement of geniposide in diabetes-associated depression mouse model

Cited by 17 publications

References 35 publications

Effect of Huang-Lian Jie-Du Decoction on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Effect of Huang-Lian Jie-Du Decoction on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats

Therapeutic potential of plant iridoids in depression: a review

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