Effect of Huang-Lian Jie-Du Decoction on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Hu, Zhipeng; Yang, Maoyi; Liu, Ya; Yang, Qian; Xie, Hongyan; Peng, Sihan; Gao, Juan; Xie, Changchun

doi:10.3389/fphar.2021.648861

Cited by 8 publications

(9 citation statements)

References 33 publications

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“…For T2DM, the fasting blood glucose (FBG) level, two-hour postprandial glucose (2hPG) level, weight, and waist circumference (WC) were the main indicators ( Jiang et al, 2020 ; Hu et al, 2021 ). HbA1c represents the average blood glucose level in the preceding 3 months and was the main outcome indicator ( Altobelli et al, 2021 ; Kim and Hur, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Dosage Modification of Traditional Chinese Medicine Prescriptions: An Analysis of Two Randomized Controlled Trials

Zhou

Zheng

et al. 2021

Front. Pharmacol.

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Traditional Chinese medicine (TCM) prescriptions lack standardization due to the complex composition of the prescribed herbs, the unclear mechanism of the formulas, and a lack of scientific data to support the dose-response relationship. Here, we proposed a new clinical strategy of dosage modification for TCM prescriptions to evaluate the clinical efficacy and guide the clinical medication. This study used two TCM prescriptions for the treatment of newly diagnosed type 2 diabetes mellitus (T2DM) to explore the key indications and the most appropriate critical values of dosage modification by analyzing two randomized controlled trials (RCTs). In this study, the indications refer to a change in the indicators from baseline at a certain time point (week 4, week 8, week 12), which could predict the change in outcome indicators, and the critical values refer to the change ranges closely related to the decrease in HbA1c at week 12. In Study 1, the correlation analysis between the change range of indicators at three time points (weeks 4, 8, and 12) from baseline and the decrease in HbA1c at week 12 from baseline (HbA1c 012) was carried out to screen the related indications. Next, we evaluate the related indications and the respective critical values to determine the key indicators, indications, and the most appropriate critical value. We conducted a correlation between the change range of key indicators (obtained from the result of Study 1) at three time points from baseline and HbA1c 012 to screen the key indications in the drug group, high-dose group, and low-dose group in Study 2. Key indications with critical values were determined to investigate the most appropriate critical value in the three groups separately. In Study 1, the key indicator was FBG, the key indication was FBG 04, and the most appropriate critical value was 0.5 mmol/L. In Study 2, the key indication was FBG 04 and the most appropriate critical value was 0.6 mmol/L in the drug group. In the high-dose group, the key indication was FBG 04, and the most appropriate critical value was 0.3 mmol/L. In the low-dose group, the key indication was FBG08, and the most appropriate critical value was 0.1 mmol/L. In addition, we summarized a verification strategy for dosage modification.

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Section: Introductionmentioning

confidence: 99%

Dosage Modification of Traditional Chinese Medicine Prescriptions: An Analysis of Two Randomized Controlled Trials

Zhou

Zheng

et al. 2021

Front. Pharmacol.

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“…After screening the titles and abstracts, 93 studies were retained. After screening the articles in full text, we further excluded 46 records, so a total of 47 studies [ 11 – 57 ] were reviewed ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The basic information of the included literature is listed in Table 1 ; 46 studies (97.9%) were from China [ 11 – 33 , 35 – 57 ], and 1 (2.1%) was from Canada [ 34 ]. According to different TCM therapies, they were divided into herbs or herbal extracts, compounds, powders, decoctions, pills, external treatment, basic theories and treatment principles of TCM, proprietary Chinese medicines, and unspecified TCM integrated therapies ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…In the intervention group using TCM therapies, there were few reports of adverse reactions, most of which were incidental cases, and no serious adverse reactions were reported. Zhipeng Hu [ 11 ] remarked that one RCT reported one case of headache, three cases of nausea and vomiting, one case of dizziness, and one case of dry cough in the TCM treatment group and one RCT reported one case of hypoglycemia and four cases of mild nausea and loss of appetite, which then gradually disappeared. Jiarong Lan [ 13 ] mentioned that no serious adverse reactions affecting vital organs occurred during the experiment.…”

Section: Resultsmentioning

confidence: 99%

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Clinical Application of Traditional Chinese Medicine Therapy for Type 2 Diabetes Mellitus: An Evidence Map

Wang

Dai

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Type 2 diabetes mellitus (T2DM), a common disease with a complex etiology in the world, is an important risk factor for severe cardiovascular and cerebrovascular diseases. However, treatments of T2DM are mainly based on Western medicine, whose severe side effects make traditional Chinese medicine (TCM) therapy more appealing to patients and clinicians. The overall clinical evidence for different TCM therapies in the treatment of T2DM is still unclear. This study aimed to adopt the evidence-mapping method and integrate the evidence from various researches on this topic, to depict the whole picture of TCM therapies for T2DM. This review included searches of PubMed, Embase, Web of Science, and three major Chinese literature databases (CNKI, VIP, and Wanfang) from inception to November 18, 2021. Two independent reviewers screened the literature, extracted information, and evaluated the quality of all included studies. A systematic review was subsequently performed. In total, 47 studies were reviewed, of which 46 studies (97.9%) were from China and 1 (2.1%) was from Canada. The evidence map was conducted according to different TCM therapies, including herbs or herbal extracts, compounds, powders, decoctions, pills, external treatment, basic theories and treatment principles of TCM, proprietary Chinese medicines, and unspecified TCM integrated therapies. According to the AMSTAR-2 scoring results, 4 papers were rated as high quality, 11 were low quality, and 32 were very low quality. Outcome indicators mainly focused on FBG, HbA1c, 2-h PBG, TC, TG, LDL-C, etc. The results showed that different types of TCM treatment had different improvement effects on the outcome indicators of T2DM. More consistent benefits were observed in the improvement of FBG, HbA1c, and 2-h PBG with treatment regimens based on basic theories and treatment principles of TCM, decoctions and pills, and unspecified TCM integrated therapies. Among herbs, ginger and Coptis root showed more improvement in all outcomes. Compounds, powders, and external treatment showed relatively consistent beneficial effects on the improvement of FBG. No serious adverse events were reported. Overall, the current evidence map provided an intuitive overview of the beneficial effects of TCM therapies in the treatment of type 2 diabetes. This study can be used as a reference for the clinical application of traditional Chinese medicine in T2DM, but due to the low-quality level of the included studies, it should be treated with caution in clinical practices.

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“…Coptidis Rhizoma (Coptis chinensis Franch, CR) and Scutellariae Radix (Scutellaria baicalensis Georgi, SR) are classical TCM combinations in clinic, which originated from Treatise on Febrile Diseases (Shang Han Lun) in 219 AD. As the herb pair, CR-SR are used together to mutually reinforce e cacy, such as Huanglian jiedu decoction, Gegenqinlian decoction and Xiexin decoction and the like [18][19][20]. Currently, many studies have shown there were phytochemical self-assembly to form supramolecular in the process of co-decoction of CR-SR [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Thermodynamics Driving Phytochemical Self-assembly Morphological Change and Antibacterial Enhancement Originated from Traditional Chinese Medicine

Liu

Lin

Huang

et al. 2022

Preprint

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Improving the clinical efficacy of the existing drugs by self-assembled strategy is the focus of current research. Herbal formula granule is a kind of modern dosage form of traditional Chinese medicine (TCM) which has sprung up in recent decades. However, whether it is equivalent to the TCM decoction that has been used for thousands of years has always been a controversial issue. In this paper, taking the herb pair of Coptidis Rhizoma - Scutellariae Radix and its main component berberine - baicalin as examples, the differences and mechanisms of self-assemblies originated from the co-decoction and physical mixture were studied, respectively. Moreover, combining multi technologies, the relationship between the morphology and antibacterial effects of self-assemblies was illuminated. Our study revealed that the physical mixture’s morphology of both the herb pair and the phytochemicals was nanofibers (NFs), while their co-decoction’s morphology was nanospheres (NPs). And driven by thermal energy, the antibacterial activity also enhanced with the change of self-assemblies’ morphology. This might be attributed to that NPs could influence amino acid biosynthesis and metabolism in bacteria. Current study provides a basis that co-decoction maybe beneficial to enhance activity and reasonable use of herbal formula granule in clinic.

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Effect of Huang-Lian Jie-Du Decoction on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Cited by 8 publications

References 33 publications

Dosage Modification of Traditional Chinese Medicine Prescriptions: An Analysis of Two Randomized Controlled Trials

Dosage Modification of Traditional Chinese Medicine Prescriptions: An Analysis of Two Randomized Controlled Trials

Clinical Application of Traditional Chinese Medicine Therapy for Type 2 Diabetes Mellitus: An Evidence Map

Thermodynamics Driving Phytochemical Self-assembly Morphological Change and Antibacterial Enhancement Originated from Traditional Chinese Medicine

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