The key components in service, such as aero‐engine turbine blades, are generally bearing complex interactions of high and low cycle fatigue loading. It is essential to make accurate fatigue life predictions for these components. In this paper, based on experimental analysis and the Miner's rule, a combined cycle fatigue life prediction model is proposed. The effect of the loading interaction of the high and low cycle fatigue is considered through the coupled damage, which is proposed based on the investigation of the fatigue test results and does not require additional material constants except for the S‐N curve parameters. The applicability of the proposed model is validated by the experimental data of three materials and the turbine blade. Compared with the T‐K model and Miner's rule, the results demonstrate that the proposed model provides high precision accuracy.