Crescent-shaped necrosis: a new imaging sign suggestive of stromal tumor of the small bowel

Rioux, Michel; Mailloux, Catherine

doi:10.1007/s002619900214

Cited by 17 publications

(5 citation statements)

References 9 publications

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“…Rectal tumors, on the other hand, tended to show homogeneous contrast enhancement. Crescent-shaped necrosis, the Torricelli-Bernouilli sign, has been reported as a sign of large GISTs [22,23]. We only saw this sign in one case (5.2%).…”

Section: Discussioncontrasting

confidence: 47%

Gastrointestinal stromal tumors: CT and MRI findings

et al. 2005

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The objective of this study was to report the CT and MRI appearances of primary and metastatic gastrointestinal stromal tumor (GIST). The clinical and imaging findings of 31 patients with histological and immunohistochemical diagnosis of GIST were reviewed. The CT and MRI findings were assessed independently for size, location, enhancement characteristics, and pattern of metastatic disease. The tumors were of enteric (n=13), gastric (n=12), duodenal (n=2), and rectal (n=3) origin. In one case the primary site was the mesentery, without involvement of bowel. Primary tumors were typically exophytic (79%), larger than 5 cm (84%), and inhomogeneously enhancing (84%). Central necrosis of all tumors (37%) and aneurysmal dilation of enteric tumors (33%) were less common. Metastases were most commonly to mesentery (26%) or liver (32%). Less common findings were ascites (7%) and omental caking (3%). Liver metastases were hypervascular in 92% of patients and rapidly became cystic following therapy with imatinib mesylate (Gleevec; Novartis, East Hanover, NJ, USA). Lung metastases, bowel obstruction, vascular invasion, and significant lymphadenopathy were not seen in any patient. GISTs have some specific CT findings which could help differentiate them from other gastrointestinal tumors. Liver metastases became cystic following therapy, mimicking simple cysts. MRI was better than single-phase CT for assessing liver metastases, while CT was more sensitive for mesenteric metastases.

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Section: Discussioncontrasting

confidence: 47%

Gastrointestinal stromal tumors: CT and MRI findings

et al. 2005

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“…The HFUS technique has already been used to determine the malignancy of carcinomas. [15][16][17][18][19][20] The necrosis detected with ultrasound is seldom used as a prognostic predictor for treatment efficacy. As an example, in 1997 Kenji et al showed that it could be a relevant tool for determining the efficacy of molecules, such as Lipiocis (CIS Bio-International, Gif-sur-Yvette, France) in the treatment of hepatocellular carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration

et al. 2006

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Tumor growth is dependent both on endothelial and tumor cells. The aim of this study was to investigate dynamically whether changes in tumor vasculature implicate tumor tissue degeneration during antiangiogenic therapies. In order to quantify intra-tumor vascularization and necrosis, we have used ultrasound technology. This study has identified essential parameters needed to quantify specifically and sensitively the number of microvessels and the extent of necrosis in xenografted human carcinomas during natural tumor evolution, using contrast-enhanced high-frequency ultrasonography with (HFCDUS) or without (HFUS) color Doppler. We showed that quantification of intra-tumor microvessels between HFCDUS and immunohistochemistry is correlated using an anti-CD31 antibody. Furthermore, quantification of tumor necrosis with HFUS was confirmed by histological examination of hematoxylin-eosin-saffraninstained sections over the observation period. Subsequently, for the assessment of novel angiogenic inhibitors, HFCDUS and HFUS were used to elucidate the underlying dynamics linking vessel inhibition and tumor eradication. We describe a novel application for HFCDUS/HFUS that constitutes an effective, convenient, and non-invasive method for clinical assessment of angiogenic inhibitors. In conclusion, we showed that tumor cells abruptly became necrotic following an antivascular therapy, whereas untreated tumors were protected from degeneration by a significant blood supply.

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“…The pelvic mass was associated with rectal and bladder infiltration. [4]. Those tumors located in the pelvis often resemble ovarian neoplasms and peritoneal carcinomatosis [1].…”

Section: Discussionmentioning

confidence: 99%