cRGD-modified and disulfide bond-crosslinked polymer nanoparticles based on iopamidol as a tumor-targeted CT contrast agent

Gao, Chunhui; Zhang, Yinghua; Zhang, Yan; Li, Shaoyong; Yang, Xinlin; Chen, Yan; Fu, Jingwei; Wang, Yinsong; Yang, Xiaoying

doi:10.1039/c9py01418g

Cited by 12 publications

(11 citation statements)

References 31 publications

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“…To simulate the redox conditions in vivo , dithiothreitol (DTT) was used to study the stability of RIP. In the presence of DTT, however, RIP became unstable and displayed two peaks ( Figure S3 ), supporting its redox-sensitivity as reported for disulfide-crosslinked systems (Chen et al., 2017 ; Yang et al., 2018 ; Gao et al., 2020 ).…”

Section: Resultssupporting

confidence: 85%

Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer

Zhu

Sun

et al. 2021

Drug Delivery

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Section: Resultssupporting

confidence: 85%

Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer

Zhu

Sun

et al. 2021

Drug Delivery

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“…S21 and S22), echoed the above conclusion. To validate the feasibility of our method, we also used one type of polymer iodine nanoparticles poly(methacrylated iopamidol) (PMAI) provided by the Yang's group (36). TEM image showed PMAI with an average diameter of 129.4 ± 9.9 nm ( fig.…”

Section: Directly Observed Iod-cbt-nps With Soft X-ray Microscopy Nanmentioning

confidence: 99%

Directly observing intracellular nanoparticle formation with nanocomputed tomography

et al. 2020

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Directly observing intracellular nanostructure formation remains challenging. In this work, using a rationally designed small-molecule 4-nitrobenzyl carbamate–Cys(SEt)-Asp-Asp-Phe(iodine)–2-cyano-benzothiazole (NBC-Iod-CBT), we directly observed intracellular nanoparticle formation with nanocomputed tomography (nano-CT). In vitro, upon glutathione reduction and nitroreductase (NTR) cleavage, NBC-Iod-CBT undergoes a CBT-Cys click condensation reaction to self-assemble nanoparticles Iod-CBT-NPs with an average linear absorption coefficient (LAC) value of 0.182 ± 0.078 μm−1 to x-ray. Nano-CT imaging of the NBC-Iod-CBT–treated, NTR-overexpressing HeLa cells showed the existence of Iod-CBT-NPs in their cytoplasm with an average LAC value of 0.172 ± 0.032 μm−1. We anticipate that our strategy could help people to deeply understand the formation mechanism of intracellular nanostructures in the near future.

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“…However, there is only a small amount of green fluorescence inside the cells in the DOC/ICG group and PP@DOC/ICG group, which shows the drug is rarely taken up by cells. The high expression of αvβ3 integrin on the surface of 4T1 cells has been confirmed by many researchers (Mi et al, 2006 ; Jahanban-Esfahlan et al, 2017 ; Kebebe et al, 2019 ; Gao et al, 2020 ). The high uptake behavior in the RPP@DOC/ICG group may be attributed to RGD targeting.…”

Section: Resultsmentioning

confidence: 63%

RGD-targeted redox responsive nano micelle: co-loading docetaxel and indocyanine green to treat the tumor

et al. 2021

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Cancer, also known as a malignant tumor, has developed into a type of disease with the highest fatality rate, seriously threatening the lives and health of people. Chemotherapy is one of the most important methods for the treatment of cancer. However, chemotherapy drugs have some problems, such as low solubility and lack of targeting, which severely limit their clinical applications. To solve these problems, we designed a block copolymer that has a disulfide bond response. The polymer uses RGD peptide (arginine-glycine-aspartic acid) as the active targeting group, PEG (polyethylene glycol) as the hydrophilic end, and PCL (polycaprolactone) as the hydrophobic end. Then we utilized the amphiphilic polymer as a carrier to simultaneously deliver DOC (docetaxel) and ICG (indocyanine green), to realize the combined application of chemotherapy and photothermal therapy. The antitumor efficacy in vivo and histology analysis showed that the DOC/ICG-loaded micelle exhibited higher antitumor activity. The drug delivery system improved the solubility of DOC and the stability of ICG, realized NIR-guided photothermal therapy, and achieved an ideal therapeutic effect.

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cRGD-modified and disulfide bond-crosslinked polymer nanoparticles based on iopamidol as a tumor-targeted CT contrast agent

Abstract: The disulfide bond-crosslinked polymer nanoparticles based on iopamidol were prepared and then surface-modified with cRGD peptide through the linkages of PEG to acquire a CT contrast agent for breast cancer-targeted imaging.

Cited by 12 publications

References 31 publications

Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer

Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer

Directly observing intracellular nanoparticle formation with nanocomputed tomography

RGD-targeted redox responsive nano micelle: co-loading docetaxel and indocyanine green to treat the tumor

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