Crime and Parkinson's: The jury is out

Santens, Patrick; Letter, Miet De; Lees, Andrew J.; Krack, Paul; Heuvel, Odile A. van den; Bloem, B.R.

doi:10.1002/mds.27436

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…This limbic-centric neurocircuitry is consistent with density of antigenic targets in the medial temporal lobe, and pattern of IgG reactivities (Figure 1e). Indeed, these regions are implicated in disinhibited behaviours, mania, and criminality in Parkinson disease, frontotemporal lobe dementias, and other neurological conditions [11,12]. Hence, there is broad anatomical plausibility for these clinical observations.…”

Section: Ta B L E 1 Clinical Characteristics Of Five Autoimmune Encep...mentioning

confidence: 99%

Criminality in patients with autoimmune encephalitis: A case series

Michael,

Varley,

Williams

et al. 2024

Euro J of Neurology

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Background and purposeDespite it being an immunotherapy‐responsive neurological syndrome, patients with autoimmune encephalitis (AE) frequently exhibit residual neurobehavioural features. Here, we report criminal behaviours as a serious and novel postencephalitic association.MethodsThis retrospective cohort study included 301 AE patients. Five of who committed crimes underwent direct assessments and records review alongside autoantibody studies.ResultsFive of 301 patients (1.7%) with AE exhibited criminal behaviours, which included viewing child pornography (n = 3), repeated shoplifting, and conspiracy to commit murder. All five were adult males, with LGI1 autoantibodies (n = 3), CASPR2 autoantibodies, or seronegative AE. None had evidence of premorbid antisocial personality traits or psychiatric disorders. Criminal behaviours began a median of 18 months (range = 15 months–12 years) after encephalitis onset. At the time of crimes, two patients were immunotherapy‐naïve, three had been administered late immunotherapies (at 5 weeks–4 months), many neurobehavioural features persisted, and new obsessive behaviours had appeared. However, cognition, seizure, and disability measures had improved, alongside reduced autoantibody levels.ConclusionsCriminal behaviours are a rare, novel, and stigmatizing residual neurobehavioural phenotype in AE, with significant social and legal implications. With caution towards overattribution, we suggest they occur as part of a postencephalitis limbic neurobehavioural syndrome.

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Section: Ta B L E 1 Clinical Characteristics Of Five Autoimmune Encep...mentioning

confidence: 99%

Criminality in patients with autoimmune encephalitis: A case series

Michael,

Varley,

Williams

et al. 2024

Euro J of Neurology

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show abstract

“…What also was evident from the earliest case reporting and has become increasingly apparent over time is that these disorders are often associated with significant adverse effects on mental and physical health, quality of life, and interpersonal relationships, sometimes with shocking consequences . In addition, over time they have led to significant changes in PD prescribing practices in part because of extensive legal action.…”

Section: The Beginning: Astute Clinical Observationsmentioning

confidence: 99%

Impulse control disorders in Parkinson's disease: A 20‐year odyssey

Weintraub

2019

Movement Disorders

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“…He also had more usual forms of ICD, including compulsive tinkering and watching pornography. Dopaminergic agonists may favor violent behavior, while there is no evidence that PD as such is associated with violent behavior . One case of serial pet killing was reported previously in a similar context, however in a patient with a clear history of violent and abusive behavior .…”

mentioning

confidence: 95%

Serial Cats Maiming Reveals Impulse Control Disorder Under Dopaminergic Agonists

Cohen

Millet

2019

Movement Disord Clin Pract

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A 45-year-old man with no significant history presented with tremor of his right hand. Parkinson's disease (PD) was diagnosed. Brain MRI was normal, and single-photon emission computed tomography SPECT with 123 I-Ioflupane (DaTSCAN) showed reduced uptake in the left putamen. Over the following 2.5 years symptoms increased, with micrography and mild hypertonia in the right upper limb. The patient then received rotigotine (2-8 mg/day). Because he complained of insomnia, rotigotine was replaced with ropinirole (2-16 mg/day). Three months after reaching the highest dosage, the patient was arrested, brought up for immediate appearance, and sentenced for having, over the past year or so, caught, maimed, and often killed several dozens of cats. Upon his release, he consulted his neurologist, who immediately diagnosed impulse control disorder (ICD) attributable to dopaminergic agonists. The treatment was stopped and the patient did not abuse cats ever again. It turned out that since he took rotigotine 8 mg/day, he used to bait cats with food, lock them between his knees, and try to dislocate their four paws in a fixed order, before releasing the maimed animals. He reported a

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Crime and Parkinson's: The jury is out

Cited by 8 publications

References 13 publications

Criminality in patients with autoimmune encephalitis: A case series

Criminality in patients with autoimmune encephalitis: A case series

Impulse control disorders in Parkinson's disease: A 20‐year odyssey

Serial Cats Maiming Reveals Impulse Control Disorder Under Dopaminergic Agonists

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