Crimean-Congo hemorrhagic fever virus in ticks in Turkey: A broad range tick surveillance study

Orkun, Ömer; Karaer, Zafer; Çakmak, Ayşe; Nalbantoğlu, Serpil

doi:10.1016/j.meegid.2017.04.017

Cited by 43 publications

(23 citation statements)

References 29 publications

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“…In Turkey, most of the studies were conducted to determine the presence of CCHFV in ticks [1,12,26,32,38]. There are no sufficient data concerning the animal infection with the CCHFV in Turkey.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Investigation of Crimean-Congo Hemorrhagic Fever infection in Cattle in some provinces of Turkey

Şevik

2018

Etlik Veteriner Mikrobiyoloji Dergisi

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Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic disease which causes lethal hemorrhagic fever in humans. The purpose of this study was to investigate the CCHF infection status in cattle in the Central Anatolia region and the central-west part of the Aegean region of Turkey. For this purpose, EDTA whole blood (n = 329) and sera (n =329) samples were obtained from epidemiologically independent herds (n =94) during the months of March 2016 and September 2017. The exposure status to CCHF was determined using ELISA for detection of CCHF virus (CCHFV) specific IgG antibodies in cattle sera samples. Real-time reverse-transcriptase PCR was used to detect viral RNA in EDTA whole blood samples. The CCHFV-specific IgG antibodies were detected in 4 out of 329 animals, accounting for 1.2% prevalence rate. CCHFV RNA was not detected in EDTA whole blood samples. The low seroprevalence suggests only sporadic introduction of CCHFV. Further epidemiological studies are needed to determine the distribution of CCHFV infection in livestock in Turkey.

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Section: Discussionmentioning

confidence: 99%

Epidemiological Investigation of Crimean-Congo Hemorrhagic Fever infection in Cattle in some provinces of Turkey

Şevik

2018

Etlik Veteriner Mikrobiyoloji Dergisi

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“…Seroconversion in animals is a good indicator of CCHFV prevalence; when domestic animals in Turkey and Bulgaria were tested for CCHFV-specific IgG antibodies, the mean seroprevalence was 26% for Bulgaria and 57% for Turkey, with some provinces reporting seroprevalence of almost 90% 94. In both rural and urban settings, similar ‘random sampling’ surveillance programmes have been employed for ticks85 95–97 and other ruminants 98 99. However, routine reservoir/host monitoring is not broadly implemented, and surveillance is challenged by a lack of serodiagnostic tests suitable for large-scale animal testing,100 no clear guidance for standardised surveillance of CCHFV in the animal health sector, and the cost of routine implementation 6.…”

Section: Challenges For Cchf Diagnosticsmentioning

confidence: 99%

“…For CCHF surveillance, harmonisation of case identification is necessary to enhance notifications and estimate disease burden, as well as to enable early warning for genetic and epidemiological shifts in the human, animal and tick populations 6 59 95 103. National CCHF prevention and control programmes should be strengthened and supported by the respective Ministries of Health and international agencies 6 63 102.…”

Section: Challenges For Cchf Diagnosticsmentioning

confidence: 99%

Diagnostic tests for Crimean-Congo haemorrhagic fever: a widespread tickborne disease

Mazzola

Kelly-Cirino

2019

BMJ Glob Health

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Crimean-Congo haemorrhagic fever (CCHF) is a widespread tickborne disease that circulates in wild and domestic animal hosts, and causes severe and often fatal haemorrhagic fever in infected humans. Due to the lack of treatment options or vaccines, and a high fatality rate, CCHF virus (CCHFV) is considered a high-priority pathogen according to the WHO R&D Blueprint. Several commercial reverse transcriptase PCR (RT-PCR) and serological diagnostic assays for CCHFV are already available, including febrile agent panels to distinguish CCHFV from other viral haemorrhagic fever agents; however, the majority of international laboratories use inhouse assays. As CCHFV has numerous amplifying animal hosts, a cross-sectoral ‘One Health’ approach to outbreak prevention is recommended to enhance notifications and enable early warning for genetic and epidemiological shifts in the human, animal and tick populations. However, a lack of guidance for surveillance in animals, harmonisation of case identification and validated serodiagnostic kits for animal testing hinders efforts to strengthen surveillance systems. Additionally, as RT-PCR tests tend to be lineage-specific for regional circulating strains, there is a need for pan-lineage sensitive diagnostics. Adaptation of existing tests to point-of-care molecular diagnostic platforms that can be implemented in clinic or field-based settings would be of value given the potential for CCHFV outbreaks in remote or low-resource areas. Finally, improved access to clinical specimens for validation of diagnostics would help to accelerate development of new tests. These gaps should be addressed by updated target product profiles for CCHFV diagnostics.

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“…Taxonomic studies on recent tick species indicated that the tick fauna of Turkey classified in two families, ten genera and 46 species infesting mammals, reptiles and birds (4,5). There are several tick-borne diseases increasing in Turkey; Crimean Congo Haemorrhagic Fever Virus, Lyme, Ehrlichiosis, Anaplasmosis and Babesiosis are commonly seen in humans or domestic animals (16,22,23).…”

Section: Introductionmentioning

confidence: 99%

Potential risk in public parks: Investigation of the tick species (Acari: Ixodida) in Bursa metropolitan area, Turkey

Aydın

Özüiçli

Girişgin

et al. 2020

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Ticks feed on a wide variety of mammals, birds, reptiles, and even amphibians. The majority of ticks choose specific animal species that are of no medical or veterinary importance for feeding, while others grasp a wide range of hosts, such as petbreeding animals or humans. They can also transmit many human and animal pathogens include viruses, bacteria, rickettsia and protozoa in Turkey. This study was carried out to detect the distribution of ticks in public parks in six districts (Osmangazi, Yıldırım, Nilüfer, Gürsu, Kestel, Mudanya) of Bursa Metropolitan Municipality area (city centre) in Turkey, between May 2016 and May 2018. A total of 6186 ticks were collected with flagging or CO2 trapping method from the public parks. The collected ticks were kept in 70% alcohol and then were identified under a stereomicroscope. Seven hard or soft tick species according to five genera were identified as Rhipicephalus sanguineus, R. turanicus, Hyalomma marginatum, H. aegyptium, Dermacentor marginatus, Ixodes ricinus and Argas persicus. Among them, R. sanguineus was the most abundant (59.79%) tick in the public parks. Ixodes ricinus increased significantly primarily in the forest areas. This is the first record of tick species in public parks in Turkey and these results may give us an acute insight into the prevalence of tick-borne infections in pets and humans.

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Crimean-Congo hemorrhagic fever virus in ticks in Turkey: A broad range tick surveillance study

Cited by 43 publications

References 29 publications

Epidemiological Investigation of Crimean-Congo Hemorrhagic Fever infection in Cattle in some provinces of Turkey

Epidemiological Investigation of Crimean-Congo Hemorrhagic Fever infection in Cattle in some provinces of Turkey

Diagnostic tests for Crimean-Congo haemorrhagic fever: a widespread tickborne disease

Potential risk in public parks: Investigation of the tick species (Acari: Ixodida) in Bursa metropolitan area, Turkey

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