Crisaborole: an emerging therapy for prurigo pigmentosa

Xu, Mingyuan; Wu, Nanhui; Du, Qian; Zhou, Zhiyu; De-zhong, Dan; Liu, Yeqiang

doi:10.1111/jdv.17938

Cited by 5 publications

(7 citation statements)

References 8 publications

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“…5,6 Restoring bal- patients and 2% crisaborole ointment, a topical phosphodiesterase 4 (PDE4) inhibitor, which can interfere with the release of interleukin-6 from M2 macrophages, was effective in controlling inflammatory lesions of PP. 7,8 There are also literature reporting friction, sweat, hormonal changes, and adult Still disease may be risk factors for PP. 3 We found that PP not always occurs in those on a low-carbohydrate diet, which accounts for 35% (7/20), while spring (40%, 8/20) was a susceptible season of PP.…”

Section: Discussionmentioning

confidence: 99%

“…Restoring balanced diet or insulin can decrease the level of ketone and treat the disease, also account for ketone may play a role in the pathogenesis of PP. Study found that proinflammatory factor IL‐6 increased in PP patients and 2% crisaborole ointment, a topical phosphodiesterase 4 (PDE4) inhibitor, which can interfere with the release of interleukin‐6 from M2 macrophages, was effective in controlling inflammatory lesions of PP 7,8 . There are also literature reporting friction, sweat, hormonal changes, and adult Still disease may be risk factors for PP 3 .…”

Section: Discussionmentioning

confidence: 99%

“…Xu et al. reported effective control of inflammatory lesions of PP after 4 weeks of topical use of 2% crisaborole ointment twice per day 8 …”

Section: Discussionmentioning

confidence: 99%

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Dermoscopy and reflection confocal microscope features of pigmented prurigo

Wang

Xiao-fang

Xiangfen

et al. 2022

Skin Research and Technology

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Background: Pigmented prurigo (PP) is a chronic and recurrent inflammatory skin disease. PP is not common clinically, but it is easily misdiagnosed because of its diversified clinical manifestations in different stages. Materials and methods:We retrospectively analyzed the clinical, histopathological, dermoscopy, and reflectance confocal microscopy (RCM) features of 20 patients diagnosed as PP. Results:The female predominance ratio was revealed with male to female of 1:4.Seven female patients were on a diet (without staple food) and one patient had a history of diabetes. Eight cases were suffered in spring, six cases in winter, three cases in summer, and three cases in autumn. Multiple sites were involved in 13 cases.Four patients had urticarial papules and plaques. Nineteen patients had erythematous papules with reticular distribution, of which 14 cases accompanied reticulate hyperpigmentation, four cases with papulovesicle, and two cases accompanied with pustules. One patient only showed reticulate hyperpigmentation. In the early lesions, dermatoscopy showed pink oval lesions, punctate or linear vessels, and pale yellow rings around the skin lesions. RCM is characterized by spongiosis, spongy vesicle, neutrophils scattered in the epidermis, which was consistent with epidermis spongiosis, neutrophils infiltrating into the upper epidermis and necrotic keratinocytes in histopathology. In the fully developed lesions, dermatoscopy showed pink lesions with brown pigment granules in the center and linear vessels in the edge. RCM showed that demarcation of epidermis and dermis is not clear, and inflammatory cells can be seen in the upper dermis and histopathologically lesions assumed a patchy lichenoid pattern, and the inflammatory cells infiltrating the dermis were dominated by lymphocytes.In the late lesions, dermatoscopy showed grainy grayish-brown or yellowish-brown pigmentation surrounding the hair follicle merging with each other. RCM showed that pigment granules were increased on the ring of basal cells, inflammatory cells were sparsely infiltrated in the dermal papilla and superficial layer, and epidermis slightlyThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Dermoscopy and reflection confocal microscope features of pigmented prurigo

Wang

Xiao-fang

Xiangfen

et al. 2022

Skin Research and Technology

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“…5 Crisaborole ointment 2% as a topical PDE4 inhibitor could target to inhibit the pro-inflammation cytokines in skin diseases via increasing levels of cyclic adenosine monophosphate (cAMP). 7 Crisaborole displayed topical antiinflammatory activity in many inflammation models such as psoriasis and atopic dermatitis. 8,9 So, successful clinical response and less side-effects in the treatment of atopic dermatitis and psoriasis prompted us to use this new immunomodulator in ZB.…”

Section: E T T E R T O T H E E D I T O R a Novel And Effective Therap...mentioning

confidence: 99%

A novel and effective therapy for Zoon balanitis: Topical crisaborole 2% ointment

Niu

Yang

Wang

et al. 2022

Acad Dermatol Venereol

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“…During the last decades, however, reports of PP cases from all over the globe accumulating. [3][4][5][6][7] Histopathological examination of early to late PP lesions comprise acute or subacute spongiosis with dyskeratosis, acanthosis, dermal lymphohistiocytic infiltrates and pigment incontinence. Although the aetiology of PP is unclear, it has been associated with dieting, nutritional deficiency, ketonaemia and diabetes mellitus.…”

Section: E T T E R T O T H E E D I T O R Prurigo Pigmentosa (Nagashim...mentioning

confidence: 99%