CRISPR/CAS9: A promising approach for the research and treatment of cardiovascular diseases

The key role of miRNA in syndromic and sporadic forms of ascending aortic aneurysms as biomarkers and targets of novel therapeutic strategies

“…Based on the evidence reported above, we propose that a strong genetic editing technique might be a solution for reversing the onset and progression of familial forms of ATAA, as well as the integration of gene-editing techniques with nanotechnology ( Dong et al, 2022 ; Testa and Musunuru, 2023 ). Therefore, the CRISPR/Cas9 system and techniques involved in the chemical modification of RNAs are emerging, and are also being incorporated into nanoparticles (NPs) for studying diseases ( Dubey and Mostafavi, 2023 ), such as ATAA, and/or investigating potential disease corrections through restoration ( Testa and Musunuru, 2023 ).…”

Research progress and application of the CRISPR/Cas9 gene-editing technology based on hepatocellular carcinoma

“…exploited CRISPR/Cas9 technology to knockdown the Kelch-like ECH-associated protein 1 (KEAP1) gene to determine whether the cross-talk between fibroblast growth factor 21 (FGF21) and NRF2 pathways was causing sorafenib resistance in HCC patients [29] . In addition to the above mentioned, its enormous potential for treatment of most human cancers was demonstrated by the fact that researchers used this technology to target the editing of genes associated with breast cancer [30] , melanoma cancer [31] , colorectal cancer [32] , pancreatic cancer [33] , cardiovascular disease [34] , inflammatory bowel disease [35] , and so on.…”