Critères paracliniques de l'imprégnation éthylique aiguë

Arditti, Joyce A.; Jean, P.; Brun, Anne; Bourdon, J; David, Jean-Marc; Jouglard, J

doi:10.1016/s1164-6756(05)80689-9

Cited by 1 publication

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“…The PPD is an aromatic amine derived from aniline 3 available as colorless crystals oxidizing quickly in the air and transforming to a brown then later to a black compound. 6 The available pure form of PDD corresponds to the PDD HCl. In adult, the acute toxicity of PPD by ingestion induce rhabdomyolisis with acute respiratory failure (cervicofacial edema), acute renal failure, 1,7-14 and myocardial lysis.…”

Section: Introductionmentioning

confidence: 99%

Myocardial lysis in a fetus induced by maternal paraphenylenediamine poisoning following an intentional ingestion to induce abortion

Abidi¹,

Himdi²,

Cherradi³

et al. 2008

Hum Exp Toxicol

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The acute toxicity of paraphenylenediamine (PPD) has been associated with several histopathological changes. In humans, acute PPD poisoning is known to cause rhabdomyolisis and particularly myocardial lysis. However, its toxicity for the fetus has never been reported in the literature. We report a case of myocardial lysis in a fetus expelled by a 22-year-old mother after apparent ingestion of an unknown amount of PPD. The patient was admitted to our intensive care unit with acute onset of respiratory distress and rhabdomyolysis. The pelvic ultrasonography on admission showed a normally progressing pregnancy of 23–24 weeks. On day 9 post-ingestion, the patient spontaneously expelled a non-viable fetus. The fetal examination did not show any external or macroscopic abnormalities. However, the histopathological exam showed an important heart and lung congestion. There was also some interstitial edema and inflammation at the base of the lingua, in addition to a chorionic villus thrombosis and abruptio placentae. The histopathology of the myocardium showed lysis of the cardiac muscle. This observation suggests that the PPD was most likely responsible for the myocardial injury in the fetus.

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Section: Introductionmentioning

confidence: 99%