Criteria for initiation and evaluation of minority donor programs and application to the example of donors of Turkish descent in Germany

Schmidt, Alexander H.; Solloch, Ute V.; Baier, Daniel M.; Yazıcı, Bülent; Özcan, Muhıt; Stahr, Andrea; Schumacher, Stéphan; Ehninger, Gerhard; Rutt, Claudia

doi:10.1038/bmt.2009.55

Cited by 32 publications

(33 citation statements)

References 18 publications

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“…In numerous countries including Turkey, the main barriers to stem cell donation are social, economic, and cultural factors. 8,16,18,19,[23][24][25] In the present study, > 60% medical students indicated that media affected their willingness to donate stem cells (Table 4). To date, media such as television, radio, and newspapers have been the primary sources of information about organ donation and transplantation 14 Media reports may positively affect public attitudes about HSCT and donation in Turkey.…”

Section: Discussionmentioning

confidence: 97%

Untitled

Kaya

Gültekin²,

Demirtaş³

et al. 2015

Exp Clin Transplant

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Objectives: Hematopoietic stem cell transplantation is a life-saving treatment, but donor numbers are lacking in Turkey and elsewhere. Increased awareness of hematopoietic stem cell transplantation among university students might help expand donation. We evaluated the effect of a brief targeted educational intervention on knowledge and attitudes about hematopoietic stem cell transplantation and donation among first-year university students in Turkey. Materials and Methods: There were 301 first-year university students (median age, 18 y) who volunteered: 163 medical students (54%) and 138 law students (46%). Before and after a brief lecture about hematopoietic stem cell transplantation, students answered a 5-item yes-or-no questionnaire regarding (1) knowledge about health benefits of hematopoietic stem cell transplantation; (2) knowledge about stem cell banking and donation in Turkey; (3) knowledge about the transplantation procedure; (4) prior experience and/or willingness to donate blood; and (5) willingness to donate stem cells. Reasons for motivation to donate blood and/or stem cells were categorized. Results before and after the lecture were evaluated with univariate and multivariate analyses. Results: The response rate was 100%. Significantly greater proportions of students had knowledge about hematopoietic stem cell transplantation and willingness to donate blood and stem cells after the lecture. There were no differences between medical and law students before the lecture. After the lecture, a significantly greater proportion of medical students indicated knowledge about health benefits of hematopoietic stem cell transplantation, stem cell banking and donation in Turkey, and the transplantation procedure. Conclusions: Brief education about hematopoietic stem cell transplantation for university students can increase knowledge and awareness about hematopoietic stem cell transplantation and cause more positive attitudes about stem cell donation.

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Section: Discussionmentioning

confidence: 97%

Untitled

Kaya

Gültekin²,

Demirtaş³

et al. 2015

Exp Clin Transplant

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“…[3][4][5][6][7] Limited data are available on the frequencies of HLA class I and class II antigens and haplotype profiles in small populations within Turkey. [8][9][10][11][12][13] Our aim was to assess the frequency of HLA-matched family donors in the Turkish population and to identify the HLA antigens and haplotypes that are most frequent in Turkey.…”

Section: Introductionmentioning

confidence: 99%

HLA Genotypes in Turkish Hematopoietic Cell Recipients and Likelihood of Finding a Matched Donor Through Family Searches

Kaya

Gönen²,

Çalışkan³

et al. 2019

Exp Clin Transplant

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Objectives: Allogeneic hematopoietic stem cell transplant is a life-saving treatment, but donor numbers in Turkey do not meet the increasing demand for this procedure. Here, our objectives were (1) to assess the frequency of HLA-matched related donors in the Turkish population and (2) to identify the HLA antigens and haplotypes that are most frequent in Turkey. Materials and Methods: The HLA genotypes of 841 consecutive recipients and 3071 family members were retrospectively reviewed. Results: Matched related donors were identified for 368/841 recipients (44%). Extended family donor searches were performed for 111/181 pediatric recipients (61%), with nonsibling matched related donors found for 23 patients (21%). Matched related donors were found for a significantly higher proportion of pediatric patients (52%) than adult patients (41%) (odds ratio of 2.5; 95% confidence interval, 1.9-4.1; P = .02). The percentage of pediatric versus adult patients with 3 or more siblings was 13% versus 46% (odds ratio of 5.6; 95% confidence interval, 3.6-8.5; P = .001). The most frequent HLA class I antigens at each locus were HLA-A*02 (20.2%), HLA-B*35 (19.5%), and HLA-C*07 (19.8%). The most frequent HLA class II antigens at each locus were HLA-DRB1*11 (21.6%) and HLA-DQB1*03 (40.2%). The most common 3-locus haplotypes were HLA-A*24 B*35 DRB1*11 (F:0.020) and HLA-A*01 B*08 DRB1*03 (F:0.015). When adult and pediatric groups were combined, the most common locus haplotypes were found in 43/345 sibling donors (12%) and in 7/23 nonsibling pediatric donors (30%) (odds ratio of 2.7; 95% confidence interval, 1.2-6.4; P = .02). Conclusions:The results indicate that, in Turkey, it can be beneficial to revise donor search algorithms to include an extended family donor search before an unrelated donor search. This type of search can be effective because of the HLA haplotype diversity in Turkey, the frequency of consanguinity, and the country's limited donor pool.

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“…40 Targeted donor recruitment, with personal and written native speaker support, and through social media, is being increasingly practiced. 41 Furthermore, addressing misconceptions about donation add to donor commitment, and improve chances for all patients, but in particular non-NWE patients, to receive optimal allogeneic stem cell grafts. 40 The subject is on the agenda of registries united in the World Marrow Donor Association.…”

Section: Discussionmentioning

confidence: 99%

The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent

et al. 2016

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© Ferrata Storti Foundation IntroductionAllogeneic hematopoietic progenitor cell transplantation plays an important role in treatment of hematooncological diseases. For patients lacking a matched related donor, an unrelated donor (UD) or cord blood unit (CBU) may provide a valuable alternative. Alternative donors are identified through registries of volunteer unrelated donors or public cord blood banks. In the past decade, the identification and availability of UD and UCB have improved. Bone Marrow Donors Worldwide (BMDW), the file of registered unrelated donors, almost tripled (from 7.4 million donors in 2001 to over 21 million in December 2012), while the inventory of unrelated CBU grew from 87,000 in 2001 to over 500,000.1 To date (2016) the number of registered donors has increased to over 27 million, and currently over 650.000 CBU are registered. Increased knowledge of the HLA system, more well-typed donors, and the availability of several search-related software tools 2-5 have facilitated and speeded up the efficiency of the search process. [6][7][8] Simultaneously searching for a back-up donor can minimize the delay if a donor is unexpectedly not fit or unavailable to donate.9 Given these recent improvements, we set out to address the questions of whether a higher percentage of patients in need of an UD/CBU may actually reach transplantation nowadays, whether the time needed to identify an UD/CBU has decreased, and whether possible factors can be identified for potential improvement. We addressed the questions in a large cohort of 3,365 consecutive UD searches performed between 2001-2012 in the Netherlands, including searches for Dutch patients of Northwestern European (NWE) and non-Northwestern European (non-NWE) descent. Methods The patients and donor searchesEuropdonor Foundation, the Dutch Stem cell donor registry, coordinates the UD searches in the Netherlands, serving a population of 16.8 million inhabitants. There were eight adult and two pediatric stem cell transplantation units in 2012 in the Netherlands, and the number of new searches increased to approximately 500 annually. All UD and CBU searches performed from 2001 until 2012 for the patients of all Dutch transplantation centers were included (n=3,365, Figure 1) for the initial 'donor found' analysis, and divided into two periods: cohort I, 2001-2006 (n=1,093) and cohort II, 2007II, -2012. Patients for whom a search was cancelled in less time than the median search time for the given year, and for whom no donor was yet identified were excluded for the 'donor found' analysis (cohort I, n=75; cohort II, n=131), leaving 3,124 evaluable search cases. Each cohort was split according to NWE and non-NWE descent. Patients were assigned to NWE or non-NWE background based upon self-identified descent.10 Descendants from the Netherlands, Germany, Belgium, Luxembourg, Great Britain, Ireland, and Scandinavia were considered NWE. The non-NWE group consisted of patients with self-reported genetic ancestry in Northern Africa (n=51), Sub-Saharan A...

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Criteria for initiation and evaluation of minority donor programs and application to the example of donors of Turkish descent in Germany

Cited by 32 publications

References 18 publications

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HLA Genotypes in Turkish Hematopoietic Cell Recipients and Likelihood of Finding a Matched Donor Through Family Searches

The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent

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