Criteria for the Diagnosis of Brain Death

Frowein, R. A.; Hamel, E.; Richard, K. E.; Haar, Karin

doi:10.1007/978-3-642-71108-4_61

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Comatose State1

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1988

1990

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Cited by 2 publications

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“…In four patients, we diagnosed brain death following the well-established criteria [9]. Although the number of measurements was small, we found that the lowest CSF [3-END/[3-LPH levels occurred after brain death ([3-END = 41.8 pg/ml; [3-LPH = 3.3 pg/ml).…”

Section: Comatose Statementioning

confidence: 96%

CSF-endorphines in acute and chronic brain lesions

Hamel

1988

Neurosurg. Rev.

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In order to answer the question of an opioid influence on consciousness, a radio-immuno-assay (n = 852) of beta-endorphin and beta-LPH (beta-lipotropic hormone) in both ventricular CSF and blood plasma was carried out in 101 neurosurgical patients. The following results were obtained: I) beta-END and beta-LPH levels were found to be lower in the CSF than in blood plasma. II) beta-END and beta-LPH in the CSF was the same in both sexes. III) beta-END levels in the CSF decreased with age. IV) beta-END and beta-LPH levels showed a diurnal rhythm with a maximum in the late a. m. hours. V) beta-END levels in the ventricular CSF tend to decrease parallel to a drop in conciousness as well as with longlasting comatous states. VI) beta-END in ventricular CSF becomes higher with increasing systolic arterial blood pressure. VII) beta-END and beta-LPH levels in ventricular CSF are not correlated with the type of the disease, CSF pressure, body temperature or respiratory changes.

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Section: Comatose Statementioning

confidence: 96%