Criteria to identify patients with atopic dermatitis in the National Health Insurance data in Korea

Jung, Hyejung; Lee, JaeIn; Jang, D. J.; Park, Miyoun; Ahn, Jong Woong

doi:10.1016/j.jdin.2020.07.006

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…However, we used the validated definitions of AD and reinforced the diagnosis using the modified strict definitions of AD. 33 Second, although a variety of assessment tools to investigate school readiness can be used according to countries and evaluation situations, 34 we used a parent-reported questionnaire to evaluate school readiness in children, which has a limited ability to evaluate the various aspects of each item in depth. However, the questionnaire is The funding organization had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.…”

Section: Discussionmentioning

confidence: 99%

“…First, we defined AD using the ICD‐10 code and medication prescriptions, not based on symptoms or tests. However, we used the validated definitions of AD and reinforced the diagnosis using the modified strict definitions of AD 33 . Second, although a variety of assessment tools to investigate school readiness can be used according to countries and evaluation situations, 34 we used a parent‐reported questionnaire to evaluate school readiness in children, which has a limited ability to evaluate the various aspects of each item in depth.…”

Section: Discussionmentioning

confidence: 99%

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Association between atopic dermatitis and school readiness in preschool children

Lee

Kim

Ryeong

et al. 2023

Pediatric Allergy Immunology

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Background Although atopic dermatitis (AD) in children affects diverse stages of life, no studies have reported on the association between school readiness and AD. Methods This study used Korean National Health Insurance data and the Health Screening Program for Infants and Children. Among all children born between 2008 and 2012 in Korea, those who were assessed for school readiness through questionnaires in a health screening program performed at 54 and 60 months old were enrolled. AD was defined based on the International Classification of Diseases codes, with two or more prescriptions of topical corticosteroids during the first 54–60 months of life. The primary outcome was the association between school readiness and AD. The questionnaire relating to school readiness comprised six items – cognitive skills, social development, activeness, concentration, emotional development, and language skills. Logistic regression analysis was used to identify the associations between school readiness and AD. Results This study included 239,673 children without AD and 38,229 children with AD. The average age at which school readiness was assessed was 4.8 years. AD was associated with vulnerability in activeness (adjusted odds ratio: 1.127; 95% confidence interval: 1.071–1.186) and concentrations (1.170; 1.093–1.254). The impact of AD on concentrations showed consistent results regardless of sex, exposure to systemic corticosteroids and antihistamines, and age at the diagnosis of AD. Conclusions Children with AD have vulnerability in school readiness in the aspects of activeness and concentration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between atopic dermatitis and school readiness in preschool children

Lee

Kim

Ryeong

et al. 2023

Pediatric Allergy Immunology

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“…It is essential to find the most accurate screening criteria for AD patients among patients with AD diagnostic codes registered in the National Health Insurance Research Database. As a result, patients who had one of the AD diagnostic codes and underwent two AD-related tests were determined to be the most appropriate [ 7 ] and were selected. The target period was from 2005 to 2016.…”

Section: Methodsmentioning

confidence: 99%

Cardiovascular comorbidities of atopic dermatitis: using National Health Insurance data in Korea

Jung

Lee

Park

et al. 2021

Allergy Asthma Clin Immunol

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Background It is well known that atopic dermatitis (AD) is associated with other allergic diseases. Recentely, links to diseases other than allergic disease have also been actively studied. Among them, the results of studies regarding AD comorbidities, especially cardiovascular disease (CVD), have varied from country to country. Objective To analyze whether the risk of CVD is different between AD patients and healthy controls using Korean National Health Insurance Data. Methods We obtained data from 2005 to 2016 from the Korean National Health Insurance Research Database. Patients with one AD code and two AD-related tests codes were selected as AD patients, and age-and sex-matched controls to the AD patients were selected from among those without AD (1:5). Each group was investigated for accompanying metabolic syndrome (which contains hypertension, type 2 diabetes, and hyperlipidemia) and CVD (angina, myocardial infarction, peripheral vascular disease, and stroke) using ICD 10 codes. Results The incidence of metabolic diseases and CVD were significantly different between the AD and control groups. Using multivariable Cox regression, differences were adjusted for sex, age, and other CVD and metabolic diseases. As a result, not only metabolic disease, but also the CVD risk of AD patients was significantly higher than that of the control group. Patients with AD had as significantly higher risk of hyperlipidemia (hazard ratio [HR] = 33.02, p < 0.001), hypertension (HR = 4.86, p < 0.001), and type 2 diabetes (HR = 2.96, p < 0.001). AD patients also had a higher risk of stroke (HR = 10.61, p < 0.001), myocardial infarction (HR = 9.43, p < 0.001), angina (HR = 5.99, p < 0.001), and peripheral vascular disease (HR = 2.46, p < 0.001). Besides hyperlipidemia, there was no difference in risk according to AD severity. Conclusion Patients with AD have a greater risk of CVD than those without AD.

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“…When employing one AD code and two AD-related treatment codes, a study in the UK found that the positive predictive value was 86% [39]. In a different study conducted in Korea, it was discovered that there was no difference in the specificity of the groups defined by the two diagnostic codes alone or by combining the diagnostic code and AD laboratory code [40]. Additionally, although many studies have defined AD based on self-report questionnaires, these questionnaire-based methods for identifying adults with AD have not been validated and are known to have the potential to introduce selection bias [41].…”

Section: Plos Onementioning

confidence: 99%

Atopic dermatitis and risk of gastroesophageal reflux disease: A nationwide population-based study

et al. 2023

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Background As atopic dermatitis (AD) has been found to be related to various comorbidities as well as substantial patient burden, questions of a possible relationship between AD and nonallergic diseases beyond allergic diseases have also been raised. Objective The aim of this nationwide matched cohort study was to evaluate whether AD would increase the development of gastroesophageal reflux disease (GERD). Methods Patients diagnosed with AD were identified from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) 2.0 database in South Korea from 2002 to 2015. Finally, 9,164 adults with AD (≥20 years old) and age, sex, household income, region of residence, disability, and baseline year-matched 9,164 controls were included in the analysis. Hazard ratio (HR) with 95% confidence interval (CI) for the development of GERD was estimated using a Cox proportional hazard regression model. Results Overall, 12.3% of the patients in the AD group developed GERD, whereas 10.4% of the individuals in the control group developed GERD. The results of the adjusted model revealed that patients with AD had a significantly increased risk of developing GERD (adjusted HR, 1.15; 95% CI, 1.06–1.26) compared with the matched controls. Increased risk of developing GERD was consistent in subgroup analyses by sex or age groups under 60 years old as well as all the sensitivity analyses performed. Conclusions This study suggested that appropriate management should be considered in adults with AD to prevent GERD, because AD was found to be associated with an increased risk of subsequent GERD.

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Criteria to identify patients with atopic dermatitis in the National Health Insurance data in Korea

Cited by 5 publications

References 3 publications

Association between atopic dermatitis and school readiness in preschool children

Association between atopic dermatitis and school readiness in preschool children

Cardiovascular comorbidities of atopic dermatitis: using National Health Insurance data in Korea

Atopic dermatitis and risk of gastroesophageal reflux disease: A nationwide population-based study

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