Critical Analysis of Methods for Assessment of Predicted No-Effect Concentration

Roman, G.; Isnard, P.; Jouany, J.M.

doi:10.1006/eesa.1998.1745

Cited by 24 publications

(12 citation statements)

References 17 publications

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“…There may be pros and cons for both methods, but it is beyond the scope of this review to discuss the relative applicability of the various distributions. The present calculations with soil quality criteria for PAH are hence an intermediate situation according to the conclusions made by Roman et al (1999). However, comparisons have shown that for relatively large data sets the difference is insignificant compared to other uncertainties connected to the risk assessment procedures for contaminated soils (Løkke 1994).…”

Section: Tgd Methods Versus Ssd Methodssupporting

confidence: 52%

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Reviews of Environmental Contamination and Toxicology

2003

Reviews of Environmental Contamination and Toxicology

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Section: Tgd Methods Versus Ssd Methodssupporting

confidence: 52%

“…In general, the output from the two methods did not vary significantly. Roman et al (1999) discussed the robustness and preciseness, i.e., dispersion of results, for three different extrapolation methods. For an exhaustive description of SSD methods, readers are referred to Posthuma et al (2002).…”

Section: Tgd Methods Versus Ssd Methodsmentioning

confidence: 99%

Reviews of Environmental Contamination and Toxicology

2003

Reviews of Environmental Contamination and Toxicology

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“…The different statistical distribution methods, such as log-normal, log-logistic, log-triangular, and Weibull [8][9][10][11][12][13][14][15], can be applied for fitting the SSD curve. Compared with the AF method, the statistical extrapolation methods can provide more precise and stable PNEC estimation if a large dataset from long-term tests is available [16,17].…”

Section: Introductionmentioning

confidence: 99%

Aquatic predicted no‐effect‐concentration derivation for perfluorooctane sulfonic acid

Pan

Wang

et al. 2011

Enviro Toxic and Chemistry

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Perfluorooctane sulfonic acid (PFOS), a representative perfluorinated surfactant, is an anthropogenic pollutant detected in various environmental and biological matrices. Some laboratory and field work has been conducted to assess the aquatic toxicity of PFOS, but little is known regarding its toxicity threshold to the aquatic ecosystem. In the present study, predicted no-effect concentrations (PNECs) were derived by four different approaches. The interspecies correlation estimation (ICE) program and final acute-to-chronic ratio (FACR) were applied to the development of PNEC based on the toxic mode of action (MOA) of PFOS. By comparison of the different PNECs, the recommended aquatic toxicity thresholds for PFOS are in the range of 0.61 to 6.66 µg/L. Based on comparison of PNEC values, microcosm results, and reported environmental concentrations, PFOS appears not to pose a serious threat to aquatic organisms. The present results demonstrate that MOA is an important consideration for the derivation of reliable PNECs; moreover, the ICE-based species sensitivity distribution (SSD) method can be used to derive PNECs when toxicological data are limited. The application of MOA and ICE for deriving PNEC values in the present study may facilitate studies on using a combination of quantitative structure-activity relationship (QSAR) models and ICE to estimate PNECs.

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“…The LC 50 response of the fish species to copper and zinc were obtained from the AQUIRE database [39] ( Table 3). The values of LC 50 were divided by 10 to calculate the predicted-no-effect-concentration (PNEC) [40]. The PNEC values were assumed to represent any possible exposure pathways such as ingestion of contaminated water and consumption of the lower trophic level organisms.…”

Section: Effect Characterizationmentioning

confidence: 99%