Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta‐analysis

Speeckaert, Reinhart; Dugardin, Judith; Lambert, Jo; Lapeere, Hilde; Verhaeghe, Evelien; Speeckaert, Marijn M.; Geel, Nanja van

doi:10.1111/jdv.14792

Cited by 81 publications

(66 citation statements)

References 81 publications

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“…Bununla birlikte; psöriyazis, atopik dermatit, liken planus ve ür- tiker gibi diğer inflamatuar hastalıklarda da çok benzer bulgular ortaya çıktığını hatırlatarak, vitiligoda gözlenen anormal oksidatif fenomenlerin, hastalığa özgü bir durum olarak kabul edilemeyeceğini, ancak bir immün aracılı deri bozukluğunun göstergesi olduğunu belirtmişlerdir. 18 Vitiligo hastalığı, deride melanosit detrüksiyonu ile giden otoimmün bir hastalıktır ve etiyolojisinde oksidatif stresin etkili olduğu düşünülmektedir. Vitiligoda oksidatif stresin etkisi ile ilgili çok sayıda çalışma yapılmıştır, ancak tarayabildiğimiz kadarıyla vitiligo hastalarında antioksidan olduğu bilinen serum bilirubin, ÜA ve Alb değerlerinin birlikte çalışıldığı bir araştırma daha önce yapılmamıştır.…”

Section: Discussionunclassified

Serum Bilirubin, Uric Acid and Albumin Antioxidant Levels in Patients with Vitiligo

Türkmen¹,

Altunışık²

2018

Turkiye Klinikleri J Dermatol

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Section: Discussionunclassified

Serum Bilirubin, Uric Acid and Albumin Antioxidant Levels in Patients with Vitiligo

Türkmen¹,

Altunışık²

2018

Turkiye Klinikleri J Dermatol

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“…Research into the pathogenesis of vitiligo suggests that oxidative stress may be the initial event in the destruction of melanocytes [56][57][58][59]. Indeed, melanocytes from patients with vitiligo were found to be more susceptible to oxidative stress than those from unaffected individuals and are more difficult to culture ex vivo than those from healthy controls [60].…”

Section: Oxidative Stressmentioning

confidence: 99%

Vitiligo: A Review

2020

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Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5-2% of the population worldwide. The disease is characterized by the selective loss of melanocytes which results in typical nonscaly, chalky-white macules. In recent years, considerable progress has been made in our understanding of the pathogenesis of vitiligo which is now clearly classified as an autoimmune disease. Vitiligo is often dismissed as a cosmetic problem, although its effects can be psychologically devastating, often with a considerable burden on daily life. In 2011, an international consensus classified segmental vitiligo separately from all other forms of vitiligo, and the term vitiligo was defined to designate all forms of nonsegmental vitiligo. This review summarizes the current knowledge on vitiligo and attempts to give an overview of the future in vitiligo treatment.

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“…[ 20 ] It is known that in vitiligo patients advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) are directly associated with extension, duration and disease activity. [ 21,22 ] Each molecule contains a unique set of absorption bands in the IR spectrum, and our approach seems to be able to detect some of the biochemical changes associated with an active disease state. While none of the discriminating regions mentioned above showed significant correlations with disease duration, the peak intensity at 1042 nm showed a weak correlation in the overall group ( ρ = −.27, P = .027) and a moderate correlation in the group of patients with active disease ( ρ = −.57, P = .0006).…”

Section: Resultsmentioning

confidence: 99%

Near‐infrared spectroscopy as a potential non‐invasive tool in the assessment of disease activity in vitiligo patients

Bruyne

Speeckaert

Himpe

et al. 2020

Experimental Dermatology

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Vitiligo is a common chronic depigmenting skin disease. We explored the utility of near-infrared (NIR) spectroscopy in the identification of spectral changes associated with disease activity in vitiligo patients. In vivo spectral measurements were performed directly on the perilesional skin of 70 vitiligo patients. Relative intensities (second derivative) at 1139, 1344, 1646 and 1839 nm appeared to be significantly lower in the perilesional region of patients with active vitiligo compared with stable disease, while the intensity at 1884 nm seemed to be significantly higher. A classification model based on the spectral ranges around those peaks generated a correct prediction in 82.9% of the cases. In conclusion, we can state that NIR spectroscopy could have potential in the assessment of disease activity. However, large-scale prospective studies are necessary to confirm our preliminary results. K E Y W O R D Sdermatology, disease activity, near-infrared, spectroscopy, vitiligo

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Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta‐analysis

Abstract: The oxidative pathway is affected in vitiligo, but its unique initiating or contributory role in the pathogenesis is less evident. Interesting data support the added value of oral antioxidants in vitiligo although confirmatory studies are missing.

Cited by 81 publications

References 81 publications

Serum Bilirubin, Uric Acid and Albumin Antioxidant Levels in Patients with Vitiligo

Serum Bilirubin, Uric Acid and Albumin Antioxidant Levels in Patients with Vitiligo

Vitiligo: A Review

Near‐infrared spectroscopy as a potential non‐invasive tool in the assessment of disease activity in vitiligo patients

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