Critical aspects of the physiological interactions between lead and magnesium

Wyparło-Wszelaki, Magdalena; Machoń-Grecka, Anna; Wąsik, Marta; Dobrakowski, Michał

doi:10.1002/jbt.22964

Cited by 4 publications

(3 citation statements)

References 53 publications

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“…Although the mechanism between lead and folate status was unclear, these findings may be attributed to the oxidative stress of lead and antioxidant properties of folate. Lead can easily cross the cell membrane, induce oxidative stress by disrupting the antioxidant system, and deplete intracellular glutathione (an important antioxidant) ( 27 , 28 ). In contrast, folate can participate in glutathione anabolism through the transsulfuration pathway ( 29 ), which may reduce the toxicity caused by lead.…”

Section: Discussionmentioning

confidence: 99%

Association between serum folate concentrations and blood lead levels in adolescents: A cross-sectional study

Zhang²,

Li³

2022

Front. Pediatr.

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As a heavy metal, lead is a common toxic agent. Its accumulation in the body is harmful to physical health, particularly in children and adolescents. Studies have reported that folate may play a protective role in lead exposure. An association between serum folate concentrations (SFC) and blood lead levels (BLL) has been documented in adults, but studies in adolescents are limited. This study investigated the relationship between SFC and BLL in American adolescents. This cross-sectional study collected relevant data on both SFC and BLL of 5,195 adolescents in the NHANES database from 2007 to 2018. Multivariable linear regressions and smooth curve fittings were adopted to evaluate the correlation between BLL and SFC. After adjusting potential confounders, we found negative relationships between BLL and SFC [β = −0.0041 (−0.0063, −0.0019)], and the associations were significant in non-Hispanic Whites, Mexican Americans, and other races but not significant in non-Hispanic blacks (P = 0.139). Furthermore, the negative trends were significant in adolescents aged 16–19 years and females aged 12–15 years but insignificant in males aged 12–15 years (P = 0.172). Therefore, these findings provide a basis for future research on the mechanism of folate in regulating blood lead levels.

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Section: Discussionmentioning

confidence: 99%

Association between serum folate concentrations and blood lead levels in adolescents: A cross-sectional study

Zhang²,

Li³

2022

Front. Pediatr.

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“…Similarly, Pb 2+ can replace other divalent metals such as zinc in zinc-finger proteins [ 92 , 93 ]. Lead can potentially lead to magnesium deficiency by inhibiting its absorption, which, in turn, may aggravate the negative effects of lead on the human body [ 94 ].…”

Section: Accumulation Competition and Toxicity Of Divalent Cationsmentioning

confidence: 99%

Direct Effects of Toxic Divalent Cations on Contractile Proteins with Implications for the Heart: Unraveling Mechanisms of Dysfunction

Gerzen,

Votinova,

Potoskueva

et al. 2023

IJMS

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The binding of calcium and magnesium ions to proteins is crucial for regulating heart contraction. However, other divalent cations, including xenobiotics, can accumulate in the myocardium and enter cardiomyocytes, where they can bind to proteins. In this article, we summarized the impact of these cations on myosin ATPase activity and EF-hand proteins, with special attention given to toxic cations. Optimal binding to EF-hand proteins occurs at an ionic radius close to that of Mg2+ and Ca2+. In skeletal Troponin C, Cd2+, Sr2+, Pb2+, Mn2+, Co2+, Ni2+, Ba2+, Mg2+, Zn2+, and trivalent lanthanides can substitute for Ca2+. As myosin ATPase is not a specific MgATPase, Ca2+, Fe2+, Mn2+, Ni2+, and Sr2+ could support myosin ATPase activity. On the other hand, Zn2+ and Cu2 significantly inhibit ATPase activity. The affinity to various divalent cations depends on certain proteins or their isoforms and can alter with amino acid substitution and post-translational modification. Cardiac EF-hand proteins and the myosin ATP-binding pocket are potential molecular targets for toxic cations, which could significantly alter the mechanical characteristics of the heart muscle at the molecular level.

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“…Short-term exposure to lead induces oxidative stress associated with elevated levels of lipid hydroperoxides (LPH) and affects the levels of essential minerals (such as calcium, magnesium, zinc, and copper) [ 10 ]. Competition between lead and magnesium for binding sites at the molecular and cellular levels, as well as at the systemic level, may represent an important aspect of lead toxicity in the context of oxidative stress, immune response, and gene expression modifications [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Postural Stability, Lead Content, and Selected Parameters of Oxidative Stress

Wąsik

Miśkiewicz-Orczyk

Słota³

et al. 2022

IJMS

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This study attempts to determine whether the increased blood lead concentration affects the posturographic test and to determine the relationship between the parameters of posture stability and selected parameters of oxidative stress. The study population consisted of 268 male employees and was divided into two equal subgroups, depending on the lead content in the blood. A posturographic examination was performed. Concentrations of lead, cadmium, zinc protoporphyrin, selected essential elements, and selected markers of oxidative stress in the blood were tested. Higher blood lead concentrations positively affected the values of the sway results: the field and the mean velocity of the center of the feet pressure in posturography. The absolute value of the proprioception ratio was similar in both subgroups. The content of malondialdehyde shows a statistically significantly higher value in a subgroup with high blood lead concentration and exhibits significant correlations only with some of the posturography parameters. The lipofuscin content in erythrocytes correlates with the results of the posturography test. Zinc protoporphyrin, total oxidant status, total antioxidant capacity, selected minerals, and metals did not correlate with the results of the posturography test. In conclusion, posturographic results correlate only with selected markers of oxidative stress, so it can be assumed that the effect on the body balance is only partial.

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Critical aspects of the physiological interactions between lead and magnesium

Cited by 4 publications

References 53 publications

Association between serum folate concentrations and blood lead levels in adolescents: A cross-sectional study

Association between serum folate concentrations and blood lead levels in adolescents: A cross-sectional study

Direct Effects of Toxic Divalent Cations on Contractile Proteins with Implications for the Heart: Unraveling Mechanisms of Dysfunction

Relationship between Postural Stability, Lead Content, and Selected Parameters of Oxidative Stress

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