Critical assessment of epidemiologic studies on the human carcinogenicity of 1,3-butadiene.

Landrigan, Philip J.

doi:10.1289/ehp.9086143

Cited by 24 publications

(9 citation statements)

References 27 publications

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“…2 A cohort study in the United Kingdom of mortality among oil refinery workers, who would be expected to have higher exposures to these compounds than residential populations, has not shown an excess risk of leukaemia or other haematopoietic malignancy. 3 Few studies of cancer risks among residential populations living near to petrochemical industry have been reported.…”

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confidence: 99%

Lymphohaematopoietic malignancy around all industrial complexes that include major oil refineries in Great Britain.

Wilkinson¹,

Thakrar²,

Walls³

et al. 1999

Occup Environ Med

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Objectives-To examine the incidence of lymphohaematopoietic malignancy around industrial complexes that include major oil refineries in Great Britain after recent public and scientific concern of possible carcinogenic hazards of emissions from the petrochemical industry. Methods-Small area study of the incidence of lymphohaematopoietic malignancies, 1974-91, within 7.5 km of all 11 oil refineries (grouped into seven sites) in Great Britain that were operational by the early 1970s and processed more than two million tonnes of crude oil in 1993.Results-Combined analysis of data from all seven sites showed no significant (p<0.05) increase in risk of these malignancies within 2 km or 7.5 km. Hodgkin's lymphoma, but no other malignancy, showed evidence (p=0.02) of a decline in risk with distance from refineries, but there was an apparent deficit of cases of multiple myeloma near the refineries (p=0.04). Conclusion-There was no evidence of association between residence near oil refineries and leukaemias, or nonHodgkin's lymphoma. A weak positive association was found between risk of Hodgkin's disease and proximity to major petrochemical industry, and a negative association with multiple myeloma, which may be chance findings within the context of multiple statistical testing. (Occup Environ Med 1999;56:577-580)

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confidence: 99%

Lymphohaematopoietic malignancy around all industrial complexes that include major oil refineries in Great Britain.

Wilkinson¹,

Thakrar²,

Walls³

et al. 1999

Occup Environ Med

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“…This reviewer noted the poor quality of exposure data available and the absence of any relationship between duration of employment or latency and lymphatic and hematopoietic cancer mortality risk. By contrast, a second reviewer (22) examined the same three studies and concluded that they strongly suggested an etiologic association between occupational exposure to I ,3-butadiene and human cancer, specifically lymphatic and hematopoietic cancer. The second reviewer noted that the excess mortality in the three studies tended to be greatest among production and maintenance workers and was absent for office staff.…”

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confidence: 99%

“…He also discounted the apparent inconsistency of subtypes of lymphatic and hematopoietic cancer reported in the different studies, citing evidence that indicates they may all derive from a common multipotential progenitor cell (23). Both reviewers (14,22) recommended that further efforts be made to quantify the butadiene exposures in the three cohorts, to permit firmer conclusions.…”

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confidence: 99%

Mortality among workers engaged in the development or manufacture of styrene-based products--an update.

Bond¹,

Bodner²,

Olsen³

et al. 1992

Scand J Work Environ Health

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BOND GG, BODNER KM, OLSEN GW, COOK RR. Mortalit y among wor kers engaged in the development or manufactu re of styrene-based produ cts -an update . Scand J Work Environ Health 1992; 18:145-54. Mortality was updated another 11 years through 1986 for a pr eviously studied cohort of 2904 male chemical workers who were potent ially exposed to styrene and related materials for a year or more between 1937 and 1971. Substantial deficits in mortality from all causes and total cancer were observed in the cohort when it was compared with white males in the United States, and also other chemical worker s who were unexposed to styrene-based products. Mortality from leukemia was slightly less than expected during the updated period , in contrast to an excess of lymphatic leukemia observed in the original period. Yet small elevations in risk of other types of lymphatic cancer, particularly multiple myeloma, persisted. The risk of these cancers did not increase with estimated inten sity or duration of styrene exposure. The findings are discussed in context with those of studies of similarly exposed workers in related industries.

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“…A comprehensive review of 1,3-butadiene epidemiology is beyond the scope ofthis paper and is the topic of the succeeding two papers (4,5 …”

Section: Summary Of Findingsmentioning

confidence: 99%

Future Directions in Epidemiologic Studies of 1,3-Butadiene-Exposed Workers

Acquavella¹

1990

Environmental Health Perspectives

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To date, epidemiologic research on 1,3-butadiene has consisted of cohort mortality studies of workers in the styrene-butadiene rubber (SBR) and butadiene monomer industries. These studies have been extremely useful both in defining the focus on human health effects to the lymphopoietic cancers and in providing a perspective on which to evaluate the available animal models for human risk assessment. The next step for epidemiologic research will involve a lymphopoietic cancer case control approach to enable a more precise assessment of whether there is a relationship between 1,3-butadiene exposure and lymphopoietic cancer. In addition, periodic mortality updates of the 1,3-butadiene-exposed worker cohorts will be important to monitor trends in lymphopoietic cancer rates and to ensure that other cancers with long latency do not begin to show elevated rates. This paper describes an industry-sponsored program of case-control and cohort mortality update studies along with the critical elements in research design and analysis for each study. Epidemiological studies will play an important role in testing hypotheses developed from toxicological studies about potential biological mechanisms of 1,3-butadiene carcinogenesis in humans.

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Critical assessment of epidemiologic studies on the human carcinogenicity of 1,3-butadiene.

Cited by 24 publications

References 27 publications

Lymphohaematopoietic malignancy around all industrial complexes that include major oil refineries in Great Britain.

Lymphohaematopoietic malignancy around all industrial complexes that include major oil refineries in Great Britain.

Mortality among workers engaged in the development or manufacture of styrene-based products--an update.

Future Directions in Epidemiologic Studies of 1,3-Butadiene-Exposed Workers

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