Critical Carotid Artery Stenosis in Coronary and Non-Coronary Patients - Frequency of Risk Factors

Vranić, Haris; Hadžimehmedagić, Amel; Haxibeqiri-Karabdic, Ilirijana; Mujacic, Ermina; Djedovic, Muhamed

doi:10.5455/medarh.2017.71.110-114

Cited by 9 publications

(10 citation statements)

References 19 publications

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“…In this context, a study was conducted by the American Heart Association, and it was reported that critical carotid artery stenosis is more often present in patients with coronary artery disease, while the association of risk factors has been demonstrated for diabetes, hypertension, and dyslipidemia. 26 While researching the risk factors for carotid artery stenosis, a study conducted by Evans 27 concluded that advanced age, tobacco smoking, hyperlipidemia, hypertension, diabetes, and physical inactivity are also factors contributing to the development of carotid stenosis, and women are relatively more at risk to develop carotid stenosis as compared to males. This patient was found to have a CCA stenosis of more than 90%, and therefore, the blood flow velocity was decreased beyond the stenosis.…”

Section: Discussionmentioning

confidence: 99%

Doppler Study of the Left Common Carotid Artery With Preocclusive Stenosis

Bacha

Gilani

Manzoor

2022

Journal for Vascular Ultrasound

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Preocclusive stenosis of the common carotid artery is a rare and potentially life-threatening entity, and the early recognition of associated internal and external carotid artery patency is important for the management plan. The patient in this case report was sent for a thyroid ultrasound for complaints of neck pain, voice change, and dysphagia, and a preocclusive stenosis of the left common carotid artery was found. Multiple collateral pathways had developed to supply blood flow to the left internal carotid artery, and there was retrograde flow in the external carotid artery and antegrade flow in the internal carotid artery. Collaterals from the left thyrocervical trunk were supplying the superior thyroid artery which supplied the external carotid artery and finally the internal carotid artery through the carotid bulb. Doppler ultrasound is valuable in the identification of preocclusive common carotid artery stenosis and mapping of collateral pathways.

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Section: Discussionmentioning

confidence: 99%

Doppler Study of the Left Common Carotid Artery With Preocclusive Stenosis

Bacha

Gilani

Manzoor

2022

Journal for Vascular Ultrasound

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“…A recent study suggested that miR-483-5p is independently associated with new-onset diabetes mellitus and cardiovascular disease ( 17 ). Besides, it is well known that dyslipidemia is a risk factor for the development of CAS ( 38 ). The present study demonstrated that miR-483-5p expression levels were significantly associated with dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Aberrant expression of miR‑483‑5p in patients with asymptomatic carotid artery stenosis and its predictive value for cerebrovascular event occurrence

Jiang

Wang

2021

Exp Ther Med

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MicroRNAs (miRNAs/miRs) may be used as novel promising diagnostic and prognostic biomarkers for various diseases, including asymptomatic carotid artery stenosis (ACAS). The present study aimed to investigate the abnormal expression of microRNA-483-5p (miR-483-5p) in patients with ACAS and to evaluate its diagnostic value for ACAS screening and its predictive value for cerebrovascular events. A total of 128 patients with ACAS and 76 healthy controls were included in the present study. The expression of miR-483-5p in serum was measured by reverse transcription-quantitative PCR. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic value of miR-483-5p in patients with ACAS. Kaplan-Meier curves were drawn and Cox regression analysis was used to determine the predictive value of miR-483-5p for cerebrovascular events in patients with ACAS. Serum miR-483-5p levels were significantly increased in patients with ACAS as compared with those in healthy controls. The expression of miR-483-5p was significantly associated with diabetes (P=0.011), dyslipidemia (P=0.047) and the degree of carotid stenosis (P=0.006) in patients with ACAS. In addition, the area under the ROC curve was 0.910, with a sensitivity of 80.5% and a specificity of 89.5% at the cutoff value of 0.705, indicating that serum miR-483-5p expression has a certain diagnostic value in patients with ACAS. Furthermore, the patients with high miR-483-5p expression had a higher proportion of cerebrovascular events than patients with low miR-483-5p levels (log-rank P=0.011) and miR-483-5p was an independent prognostic marker for predicting the occurrence of cerebrovascular events in patients with ACAS. The results indicated that miR-483-5p expression is significantly increased in patients with ACAS and that abnormal miR-483-5p expression may be a candidate biomarker for ACAS diagnosis and the prediction of cerebrovascular event occurrence.

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“…According to Vranic (2017), the factors that play a major role in the pathogenesis and prediction of treatment for cardiovascular and cerebrovascular diseases are: hyperlipidemia, diabetes mellitus, hypertension, and smoking [12]. It has been reported that patients undergoing coronary bypass surgery usually have atherosclerosis in the carotid artery.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Carotid Artery Stenosis (CAS) Among Cardiac Surgery Patients

Alsalmi¹,

Abdeen²

2023

Cureus

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Introduction: Cardiac disease and carotid atherosclerosis rates have increased in recent years. Carotid artery stenosis (CAS) has been recognized as a high-risk factor of perioperative stroke among cardiac surgery patients.Aims: The aims of the study are to identify the prevalence and common risk factors of CAS among patients undergoing cardiac surgery that include coronary artery bypass surgery or valvular cardiac surgery.Materials and Methods: This retrospective cross-sectional study was conducted in the radiology department at Medina Cardiac Center, Al Madinah Al-Munawara. The inclusion criteria for the study were patients aged ≥ 20 years who were scheduled for coronary artery bypass surgery or valvular cardiac surgery and had carotid duplex examination before surgery. A Philips X matrix IU22 linear-array ultrasound probe (Philips, Bothell, WA) was used to scan the common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA), and vertebral artery.Results: Of the 261 patients in this study, 78.5% ( n = 205) were male. The mean age of patients was 61.6 ± 11.3 years (median: 62.0; range: 55.5-68.0). The overall prevalence of CAS was 71% (n = 187): 52% (n = 136) with bilateral CAS and 19.5% (n = 51) with unilateral CAS. Age group was significantly associated with bilateral CAS and the severity of CAS (p = 0.001). Diabetes mellitus, hypertension and both diabetes mellitus and hypertension together were significantly associated with CAS status (p < 0.05, for all). A significantly higher proportion of smokers had a mild level of CAS on the left side compared to non-smokers (55.8% vs. 46.5%, p = 0.033). Gender and weight status were not linked to severity of CAS. Conclusion:This study shows a high prevalence of CAS among cardiac surgery patients. In addition, older age, diabetes mellitus, and hypertension were found to be major risk factors for CAS. Gender and weight status were not associated with CAS. Preoperative carotid duplex scan is a useful exam to identify CAS among cardiac surgery patients and, therefore, to predict and reduce postoperative neurological complications.

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Critical Carotid Artery Stenosis in Coronary and Non-Coronary Patients - Frequency of Risk Factors

Cited by 9 publications

References 19 publications

Doppler Study of the Left Common Carotid Artery With Preocclusive Stenosis

Doppler Study of the Left Common Carotid Artery With Preocclusive Stenosis

Aberrant expression of miR‑483‑5p in patients with asymptomatic carotid artery stenosis and its predictive value for cerebrovascular event occurrence

Prevalence and Risk Factors of Carotid Artery Stenosis (CAS) Among Cardiac Surgery Patients

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