-Various perturbation series are factorially divergent. The behavior of their high-order terms can be found by Lipatov's method, according to which they are determined by instanton configurations of appropriate functional integrals. When the Lipatov asymptotics is known and several lowest order terms of the perturbation series are found by direct calculation of diagrams, one can gain insight into the behavior of the remaining terms of the series. Summing it, one can solve (in a certain approximation) various strong-coupling problems. This approach is demonstrated by determining the Gell-Mann-Low functions in ϕ 4 theory, QED, and QCD for arbitrary coupling constants. An overview of the mathematical theory of divergent series is presented, and interpretation of perturbation series is discussed. Explicit derivations of the Lipatov asymptotics are presented for some basic problems in theoretical physics. A solution is proposed to the problem of renormalon contributions, which hampered progress in this field in the late 1970s. Practical perturbation-series summation schemes are described for a coupling constant of order unity and in the strong-coupling limit. An interpretation of the Borel integral is given for "non-Borel-summable" series. High-order corrections to the Lipatov asymptotics are discussed.