2017
DOI: 10.1128/aem.01190-17
|View full text |Cite
|
Sign up to set email alerts
|

Critical Knowledge Gaps in Our Understanding of Environmental Cycling and Transmission of Leptospira spp

Abstract: Exposure to soil or water contaminated with the urine of Leptospira-infected animals is the most common way in which humans contract leptospirosis. Entire populations can be at high risk of leptospirosis while working in inundated fields, when engaging in aquatic sports, or after periods of heavy rainfall. The risk of infection after contact with these environmental sources depends on the ability of Leptospira bacteria to survive, persist, and infect new hosts. Multiple variables such as soil and water pH, tem… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

11
106
0
3

Year Published

2018
2018
2024
2024

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 81 publications
(120 citation statements)
references
References 80 publications
11
106
0
3
Order By: Relevance
“…This seasonality pattern is comparable to other South East Asian countries such as Thailand, Laos and Indonesia where the marked incidence was recorded during the wet season [7,9,34]. The survival and longevity of leptospires once it is shed into the environment, will have a direct bearing on the infection risk which implies that environmental survival and persistence are highly dependent on environmental conditions [2].…”
Section: Discussionsupporting
confidence: 72%
See 1 more Smart Citation
“…This seasonality pattern is comparable to other South East Asian countries such as Thailand, Laos and Indonesia where the marked incidence was recorded during the wet season [7,9,34]. The survival and longevity of leptospires once it is shed into the environment, will have a direct bearing on the infection risk which implies that environmental survival and persistence are highly dependent on environmental conditions [2].…”
Section: Discussionsupporting
confidence: 72%
“…World Health Organization (WHO) has discerned leptospirosis as a neglected tropical disease of global importance, thus requiring further research to understand its epidemiology, disease biology and ecology as well as its transmission dynamics. This disease is caused by a spirochete of the genus Leptospira that colonize the kidneys of a wide diversity of peridomestic animals (rats, horses, cows, dogs, and pigs) and feral animals (bats, coyotes and sea lions) [2].…”
Section: Introductionmentioning
confidence: 99%
“…It is currently assumed that pathogenic virulent leptospires are unable to multiply in the environment [18,19]. However, although the survival capacity of most species outside a host is not questionable, little is known on the environmental factors and determinants conditioning this survival [20]. The capacity of Leptospira to adapt to parameters such as osmolarity inside a host or in nature was also shown to be species-specific and related to the size of the Leptospira genome [21].…”
Section: Introductionmentioning
confidence: 99%
“…Leptospirosis is an important zoonotic disease caused by spirochete bacteria from the genus Leptospira (1). The disease is globally distributed but is more prevalent in tropical and subtropical areas, where temperature and humidity are favorable for Leptospira survival and persistence in the environment (2,3). Several outbreaks of leptospirosis have occurred after an extensive heavy rainfall and flooding (4)(5)(6), including a recent outbreak in Krabi province, southern Thailand, in January 2017.…”
mentioning
confidence: 99%