2008
DOI: 10.1038/onc.2008.213
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Critical pathways in cellular senescence and immortalization revealed by gene expression profiling

Abstract: Bypassing cellular senescence and becoming immortal is a prerequisite step in the tumorigenic transformation of a cell. It has long been known that loss of a key tumor suppressor gene, such as p53, is necessary, but not sufficient, for spontaneous cellular immortalization. Therefore, there must be additional mutations and/or epigenetic alterations required for immortalization to occur. Early work on these processes included somatic cell genetic studies to estimate the number of senescence genes, and microcell-… Show more

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Cited by 281 publications
(264 citation statements)
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“…S1). [27][28][29] Taken together, we found IL-15-expanded, Lchain-specific T cells have a higher percentage of S/G2 phase cells after stimulation, lower expression of cell cycle inhibitors, less production of senescence-associated proinflammatory cytokines, higher expression of CD27 and CD28, and downregulation of cellular senescence biomarker genes, suggesting that IL-15-expanded, L-chain-specific T cells exhibit senescence delay. 24,26,30,31 IL-15 regulates senescence delay in antigen-specific T cells through the JAK3-STAT5 signaling pathway…”
Section: Il-15-expanded Id L-chain-specific T Cells Exhibited Delayementioning
confidence: 81%
“…S1). [27][28][29] Taken together, we found IL-15-expanded, Lchain-specific T cells have a higher percentage of S/G2 phase cells after stimulation, lower expression of cell cycle inhibitors, less production of senescence-associated proinflammatory cytokines, higher expression of CD27 and CD28, and downregulation of cellular senescence biomarker genes, suggesting that IL-15-expanded, L-chain-specific T cells exhibit senescence delay. 24,26,30,31 IL-15 regulates senescence delay in antigen-specific T cells through the JAK3-STAT5 signaling pathway…”
Section: Il-15-expanded Id L-chain-specific T Cells Exhibited Delayementioning
confidence: 81%
“…The microsatellite markers, D3S1478 and D3S1578, located on chromosome 3p21.3 and flanking the RASSF1A locus, were used to analyze the LOH on 9 uveal melanoma tumors (13)(14)(15)(16)(17)(18)(19)(20)(21). The methylation of RASSF1A promoter was analyzed by MSP on PCR products with specific primers from bisulfite-treated genomic DNA.…”
Section: Downexpression Of Rassf1a In Uveal Melanoma Cell Linesmentioning
confidence: 99%
“…13,14), reduce telomere length (15), resulting in an accumulation of senescent prostate epithelial cells (PrEC) in BPH (16). Accordingly, expression of a set of ISGs is upregulated during the onset of prostate epithelial cellular senescence (17)(18)(19). Furthermore, levels of the IFNb increase in human diploid fibroblasts (HDF) when HDFs approach cellular senescence (20) and the expression of IFNinducible proteins is upregulated in senescent PrECs (21) and HDFs (22).…”
Section: Introductionmentioning
confidence: 99%