1982
DOI: 10.1007/bf00688883
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Critical pulses of anisomycin drive the circadian oscillator inGonyaulax towards its singularity

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Cited by 62 publications
(30 citation statements)
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“…A "translational" clock would be expected to be especially susceptible to disruption by inhibitors of protein synthesis, as has been found in many different systems (40)(41)(42)(43)(44). It could involve a closed loop of many different regulatory proteins, each one of which controls the synthesis of the next in the series (the "clock" proteins); but each would also control the synthesis of certain cellular proteins involved in overt rhythms ("hands" of the clock, such as LBP).…”
Section: Discussionmentioning
confidence: 99%
“…A "translational" clock would be expected to be especially susceptible to disruption by inhibitors of protein synthesis, as has been found in many different systems (40)(41)(42)(43)(44). It could involve a closed loop of many different regulatory proteins, each one of which controls the synthesis of the next in the series (the "clock" proteins); but each would also control the synthesis of certain cellular proteins involved in overt rhythms ("hands" of the clock, such as LBP).…”
Section: Discussionmentioning
confidence: 99%
“…Surprisingly, only three previous studies have reported positive results with period lengthening to translation inhibitors: anisomycin lengthened the period to 31 hr or longer in Aplysia (28), and cycloheximide lengthened period up to 36 hr in Euglena (29) and up to 33 hr in Chlamydomonas (30). Possibly, expression of circadian rhythmicity is not 4 observable with constant inhibitor treatment at higher concentrations where period lengthening occurs (16,38,55 (35,43), Neurospora (36,40,43), Gonyaulax (38,42,(45)(46)(47), Phaseolus (39), Aplysia (31,34), and hamster (33,41) and for anisomycin pulses in Gonyaulax (37,38,42,45,47), Aplysia (27,28,32,34), chick pineal (49), and hamster (33,48). On the basis of these data, it has been suggested that translation is a requirement for the circadian pacemaker mechanism (24, 27, 28, 30-32, 35, 36, 40, 43, 44, 47, 49, 50), or more specifically, that translation is a phasedependent requirement (24,28,32,35,36,40,…”
Section: Methodsmentioning
confidence: 99%
“…7, 8, and 23-26). Continuous treatment of circadian pacemakers with translation inhibitors lengthens the period of the rhythms (27)(28)(29)(30), whereas pulse treatments generate phase-dependent phase shifts of the circadian pacemaker (27,28,(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49) in a variety of organisms. On the basis of this type of experiment it has been suggested that translation is a requirement for the circadian pacemaker (17, 27, 28, 30-32, 35, 36, 40, 43, 44, 47, 49, 50), or more specifically, that translation is a phasedependent requirement for the circadian pacemaker (24,28,32,35,36,40,43,44,49).…”
mentioning
confidence: 99%
“…These theoretical results motivated experimental studies in the algae Gonyaulax [70] and in Neurospora [71]. In each of these model organisms either a chemical or a light pulse can drive the system towards its singularity.…”
Section: Rhythm Suppression By a Light Pulsementioning
confidence: 83%