Critical review of the publications on the genotoxicology of aluminium salts: 1990–2018

Jenkinson, P.

doi:10.1093/mutage/geab008

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…It is interesting to note that the results are often inconsistent and contradictory, and there may be methodological flaws. For this reason, to date, it is not possible to state with certainty that aluminium salts used as adjuvants (at the recommended doses) can have toxic effects, despite their ability to create more or less intense oxidative stress [ 54 ].…”

Section: Delivery Systemsmentioning

confidence: 99%

An Overview of Vaccine Adjuvants: Current Evidence and Future Perspectives

et al. 2022

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Vaccinations are one of the most important preventive tools against infectious diseases. Over time, many different types of vaccines have been developed concerning the antigen component. Adjuvants are essential elements that increase the efficacy of vaccination practises through many different actions, especially acting as carriers, depots, and stimulators of immune responses. For many years, few adjuvants have been included in vaccines, with aluminium salts being the most commonly used adjuvant. However, recent research has focused its attention on many different new compounds with effective adjuvant properties and improved safety. Modern technologies such as nanotechnologies and molecular biology have forcefully entered the production processes of both antigen and adjuvant components, thereby improving vaccine efficacy. Microparticles, emulsions, and immune stimulators are currently in the spotlight for their huge potential in vaccine production. Although studies have reported some potential side effects of vaccine adjuvants such as the recently recognised ASIA syndrome, the huge worth of vaccines remains unquestionable. Indeed, the recent COVID-19 pandemic has highlighted the importance of vaccines, especially in regard to managing future potential pandemics. In this field, research into adjuvants could play a leading role in the production of increasingly effective vaccines.

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Section: Delivery Systemsmentioning

confidence: 99%

An Overview of Vaccine Adjuvants: Current Evidence and Future Perspectives

et al. 2022

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“…This may be connected with the metastatic process of breast cancer (activating matrix metalloproteinase 9 (MMP9) and matrix metalloproteinase 14 (MMP14)). Lastly, Al is considered a proinflammatory and proapoptotic agent, up-regulating various cytokines such as Interleukin-1β and tumor necrosis factor α (TNFα) in numerous tissues [ 4 , 28 , 54 , 55 , 56 , 57 ].…”

Section: Introductionmentioning

confidence: 99%

Aluminium in the Human Brain: Routes of Penetration, Toxicity, and Resulting Complications

Bryliński

Kostelecka

Woliński

et al. 2023

IJMS

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Aluminium (Al) is the most ubiquitous metal in the Earth’s crust. Even though its toxicity is well-documented, the role of Al in the pathogenesis of several neurological diseases remains debatable. To establish the basic framework for future studies, we review literature reports on Al toxicokinetics and its role in Alzheimer’s disease (AD), autism spectrum disorder (ASD), alcohol use disorder (AUD), multiple sclerosis (MS), Parkinson’s disease (PD), and dialysis encephalopathy (DE) from 1976 to 2022. Despite poor absorption via mucosa, the biggest amount of Al comes with food, drinking water, and inhalation. Vaccines introduce negligible amounts of Al, while the data on skin absorption (which might be linked with carcinogenesis) is limited and requires further investigation. In the above-mentioned diseases, the literature shows excessive Al accumulation in the central nervous system (AD, AUD, MS, PD, DE) and epidemiological links between greater Al exposition and their increased prevalence (AD, PD, DE). Moreover, the literature suggests that Al has the potential as a marker of disease (AD, PD) and beneficial results of Al chelator use (such as cognitive improvement in AD, AUD, MS, and DE cases).

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Genotoxic impact of aluminum-containing nanomaterials in human intestinal and hepatic cells

Jalili

Huet

Burel

et al. 2022

Toxicology in Vitro

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Background: Exposure of consumers to aluminum-containing nanomaterials (Al NMs) through numerous products is an area of concern for public health agencies since human health risks are not completely elucidated. In addition, the available data on the genotoxicity of Al 2 O 3 and Al 0 NMs are inconclusive or rare. In order to provide further information, the present study investigated the in vitro genotoxic potential of Al 0 and Al 2 O 3 NMs in intestinal and liver cell models since these tissues represent organs which would be in direct contact or could experience potential accumulation following oral exposure.Methods: Differentiated human intestinal Caco-2 and hepatic HepaRG cells were exposed to Al 0 and Al 2 O 3 NMs (0.03 to 80 µg/cm2) and the results were compared with those obtained with the ionic form AlCl 3 . Several methods, including H2AX labelling, the alkaline comet assay and micronucleus (MN) assays were used. Oxidative stress and oxidative DNA damage were assessed using High Content Analysis (HCA) and the formamidopyrimidine DNA-glycosylase -modi ed comet assay respectively. Moreover, carcinogenic properties of Al NMs were investigated through the cell transforming assay (CTA) in Bhas 42 cells.Results: The three forms of Al did not induce chromosomal damage when tested in the MN assay. Furthermore, no cell transformation was observed in Bhas 42 cells. However, although no production of oxidative stress was detected in HCA assays, Al 2 O 3 NMs induced oxidative DNA damage in Caco-2 cells in the comet assay following a 24 h treatment. Considerable DNA damage was observed with Al 0 NMs in both cell lines in the comet assay, although this was likely due to interference with these NMs. Finally, no genotoxic effects were observed with AlCl 3 . Conclusion:The slight effects observed with Al NMs are therefore not likely to be related to ion release in the cell media.

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Critical review of the publications on the genotoxicology of aluminium salts: 1990–2018

Cited by 3 publications

References 41 publications

An Overview of Vaccine Adjuvants: Current Evidence and Future Perspectives

An Overview of Vaccine Adjuvants: Current Evidence and Future Perspectives

Aluminium in the Human Brain: Routes of Penetration, Toxicity, and Resulting Complications

Genotoxic impact of aluminum-containing nanomaterials in human intestinal and hepatic cells

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