Critical review on Bhaishajya KaaIa (time of drug administration) in Ayurveda

Junjarwad, Ashwini V; Savalgi, Pavan B; Vyas, Mahesh

doi:10.4103/0974-8520.115436

Cited by 5 publications

(1 citation statement)

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“…For the action of the drug on the lower abdomen, it is given before meals, resulting in pain relief. There is a published critical review on Bhaishajya kala (time of drug administration) in Ayurveda 27 . However, this case is a real example of these concepts discussed in the review.…”

Section: Discussionmentioning

confidence: 99%

Appropriate Timing of Medicine (Aushadhi Sevan Kal) Can Better Impact Patient Outcome — A Case Report of Acute Gastroenteritis (Atisara)

Nakanekar,

Khobarkar

2024

JNR

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Aushadh sewan kal (ASK) is vital in managing the disease. ASK varies with various factors such as the disease’s strength, the patient’s strength, the predominance of Dosha (regulatory functional factors of the body), Dushya (which gets vitiated), etc. Precision in ASK is vital to achieve greater efficacy and a lesser quantity of medicine. Lack of this precision may produce unwanted effects. A 31-year-old female patient came to OPD of Kayachikitsa GAC, Nagpur, with complaints of loose motion (10 episodes), vomiting (4 episodes), nausea, abdominal pain, body aches, and general weakness since one day, headache, burning sensation in the stomach since morning. She was diagnosed with acute gastroenteritis (Atisara). Atisara treatment containing Musta, Takra, and Bilvavleh was used. After the modification of the same medicines in ASK, pain reduction and complete recovery were achieved. There was a significant decrease in subjective parameters after administering medicine in appropriate ASK. Significant improvements in Jaran Shakti score (Capacity to digest), Abhyawaran shakti score (capacity to eat), and Ruchi factor (appetite) were also noted. ASK is important in the administration of Aushadha (medicine). Negligence in ASK may decrease the efficacy of medications. This case report emphasises the relationship between Agni (metabolic power), gut microbiome, circadian rhythm, and ASK. This case report gives future direction for various studies to understand the interplay between Agni (metabolic energy), gut microbiome, circadian rhythm, ASK, and the effect of this interplay on patient outcome.

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Section: Discussionmentioning

confidence: 99%

Appropriate Timing of Medicine (Aushadhi Sevan Kal) Can Better Impact Patient Outcome — A Case Report of Acute Gastroenteritis (Atisara)

Nakanekar,

Khobarkar

2024

JNR

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Metabolic alterations in healthy human adults associated with chronotypes-a pilot clinical trial

Shirolkar,

Pawar,

Chougule

et al. 2024

Preprint

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Chronobiology pertains to the examination of biological rhythms. The phenotypic manifestation of the internal clock is referred to as chronotype. Currently, there exists a limited number of studies linking biomolecules and pathways to specific chronotypes. Metabolites, possess great versatility, and are crucial in defining the phenotype of an organism. Therefore, it would be of clinical significance to establish an association between the metabolite signature and chronotype. In our investigation, we conducted an analysis of the chronotypes of eight healthy volunteers using a validated ICER chronotype questionnaire, which is an adapted version of the Munich Chronotype Questionnaire (MCTQ). By employing rapid resolution liquid chromatography - tandem mass spectrometry (RRLC-MS) on serum samples from these volunteers, a comprehensive and unbiased profiling of metabolites was conducted to evaluate the signature metabolites and molecular pathways. Interestingly, the metabolic pathways of Purine, Glycerophospholipid, and Thiamine were noticed to be particularly prominent. Remarkable marker metabolites associated with morning and intermediate chronotypes included Thiamine triphosphate, Deoxyuridine, Cyclic GMP, Epinephrine, Glycocholic Acid, Adenosine triphosphate, Phosphoadenosine phosphosulfate, lysophospholipid, phosphatidylethanolamines, and phosphatidic acid. When analyzed in the intermediate and morning group, Adenosine triphosphate and glycoholic acid were found to be downregulated, while Phosphoadenosine phosphosulfate was upregulated. Our omics analysis clearly demonstrated a distinct differentiation between chronotypes based on their metabolism and associated pathways. Consequently, this offers a potential tool for the identification and characterization of marker compounds to assign chronotypes, thereby facilitating the incorporation of chronotherapy in disease diagnosis.

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Role of Vyana Vayu in CardioVascular System, Etiopathogenesis and Therapeutic Strategies: An Ayurveda Perspective

Baikampady

Hiremath

Varyani

et al. 2022

Advancements in Cardiovascular Research and Therapeutics: Molecular and Nutraceutical Perspectives

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A systems approach to health is the hallmark of Ayurveda. It believes in preventing disease and maintaining and restoring health. The entire concept stands on three fundamental functional units-Vata, Pitta and Kapha, where Vata, mobilizes the other two units. Depending on their locations, Vata (Vayu) is classified into five subtypes, where each has its distinct role to perform. Vyana Vayu (VV), an important subtype of Vata, is synthesized in myocytes and responsible for the genesis of the action potential. A key regulator in contractile functions, VV propels out nutrients from the heart. It not only mediates intracrine and paracrine activities but modulates the vascular tone too. Wherever there is scope to flow, VV has its unique role to contribute. Ancient scholars of Ayurveda have identified its ubiquitous role in the endogenous system, where all the activities depend on VV. Hence, preventing VV from any stimulus is of paramount importance since they consequently lead to various cardio vascular diseases (CVD). Classical texts have addressed the prognosis in six discrete phases where each phase can be avoided strategically. Highlighting the precipitants that attenuate VV, we focus on addressing those phases along with curative measures so that the functions of Vyana Vayu can be restored.

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Critical review on Bhaishajya KaaIa (time of drug administration) in Ayurveda

Cited by 5 publications

References 0 publications

Appropriate Timing of Medicine (<i>Aushadhi Sevan Kal</i>) Can Better Impact Patient Outcome — A Case Report of Acute Gastroenteritis (<i>Atisara</i>)

Appropriate Timing of Medicine (<i>Aushadhi Sevan Kal</i>) Can Better Impact Patient Outcome — A Case Report of Acute Gastroenteritis (<i>Atisara</i>)

Metabolic alterations in healthy human adults associated with chronotypes-a pilot clinical trial

Role of Vyana Vayu in CardioVascular System, Etiopathogenesis and Therapeutic Strategies: An Ayurveda Perspective

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