Critical role of environmental factors in the pathogenesis of psoriasis

Zeng, Jinrong; Luo, Shuaihantian; Huang, Yumeng; Lu, Qianjin

doi:10.1111/1346-8138.13806

Cited by 177 publications

(154 citation statements)

References 117 publications

(207 reference statements)

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“…A common clinical extracutaneous manifestation of the disease is psoriatic arthritis (PsA) affecting around one‐third of patients with psoriasis . Psoriasis is a multifactorial disease and may develop in genetically predisposed individuals under certain environmental factors including gut microbiome changes …”

Section: Methodsmentioning

confidence: 99%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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The human microbiome is a wide range of microorganisms residing in and on our body. The homeostasis between host immune system and the microbial environment allows mutual benefits and protection. Physiological bacterial colonization is essential for the establishment of organism immunity. The human microbiota ecosystem can be divided into several compartments, out of which intestinal flora strongly affects our health and plays a crucial role in the pathophysiology of many diseases. The gastrointestinal tract, being a major guardian of the immune system, maintains the homeostasis with the commensal microorganisms by tolerating the typical flora antigens. The dysbiosis may trigger an inflammatory response followed by tissue damage or autoimmune processes. The gut microbiome alterations are linked to the pathogenesis of the allergic, cardiovascular, gastrointestinal, metabolic, neurodevelopmental, psychiatric and neurodegenerative diseases and cancer. Moreover, there is increasing evidence connecting the skin condition with the gastrointestinal microbiome, which has been described as the skin–gut axis. The aim of this study was to review the literature regarding the role of the gut microbiome alterations in the pathogenesis of selected allergic and inflammatory skin diseases.

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Section: Methodsmentioning

confidence: 99%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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“…As desquamative erythema can affect any site of skin, psoriasis profoundly impairs the patients' quality of life, treatment satisfaction and adherence, and socioeconomic stability . Skin injury and environmental factors such as smoking trigger or exacerbate psoriatic lesions . The development of psoriasis at sites of traumatized skin is called Koebner phenomenon .…”

Section: Introductionmentioning

confidence: 99%

The CCL20 and CCR6 axis in psoriasis

et al. 2019

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Psoriasis is a TNF‐α/IL‐23/IL‐17A–mediated inflammatory skin disease that causes a significant socioeconomic burden in afflicted patients. IL‐17A–producing immune cells, including Th17 cells, are crucial effector cells in the development of psoriasis. IL‐17A stimulates epidermal keratinocytes to produce CCL20, which eventually recruits CCR6 + Th17 cells into the lesional skin. Thus, the CCL20/CCR6 axis works as a driving force that prepares an IL‐17A–rich cutaneous milieu. In this review, we summarize the current research topics on the CCL20/CCR6 axis and the therapeutic intervention of this axis for psoriasis.

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“…1,5 It is indicated from recent studies that rosacea is associated with many systemic diseases, such as cardiovascular disease, gastrointestinal disorders and diabetes. [10][11][12][13][14][15] Johnson et al 11 reported that lower carbohydrate diet may bring benefits to psoriatic patients. 8,9 Based on the potential correlations of these risk factors with rosacea, we investigated the possible involvement of dietary factors in the occurrence and severity of rosacea.…”

Section: Introductionmentioning

confidence: 99%

Relationship between rosacea and dietary factors: A multicenter retrospective case–control survey

Yuan

Huang

Wang

et al. 2019

The Journal of Dermatology

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Although patients with rosacea often consult dermatologists for dietary factors that might be related to their skin disorders, few studies have been conducted to research the relationship between rosacea and dietary factors. The purpose of this study was to evaluate the potential relationship between rosacea and diet among the large Chinese population with rosacea, which would provide dietary guidelines for patients with rosacea. A multicenter case–control study was conducted. The feeding frequency 2 years before the occurrence of rosacea was collected by standardized questionnaires. Multiple logistic regression analysis was used to calculate risks related to the diet. One thousand three hundred and forty‐seven patients with rosacea and 1290 controls were enrolled in our study. We found that high‐frequency intake of fatty food and tea presented a positive correlation with rosacea, while high‐frequency dairy product intake showed significant negative correlation with rosacea. Sweet food, coffee and spicy food appeared to be independent of any subset of rosacea in our study. However, high‐frequency dairy product intake showed a borderline beneficial effect on rosacea severity. We further analyzed the correlation between diet and the subtype of rosacea. We found that high‐frequency fatty intake was associated with erythematotelangiectatic rosacea (ETR) and phymatous rosacea, while high‐frequency tea intake was only associated with ETR. In addition, high‐frequency dairy product intake showed negative correlations with ETR and papulopustular rosacea. Rosacea is associated with some dietary factors, and our study is valuable in establishing dietary guidelines to prevent and improve rosacea.

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Critical role of environmental factors in the pathogenesis of psoriasis

Cited by 177 publications

References 117 publications

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

The CCL20 and CCR6 axis in psoriasis

Relationship between rosacea and dietary factors: A multicenter retrospective case–control survey

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