2014
DOI: 10.1002/ana.24300
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Critical role of the right uncinate fasciculus in emotional empathy

Abstract: Objective: Common neurological diseases or injuries that can affect the right hemisphere, including stroke, traumatic brain injury, and frontotemporal dementia, disrupt emotional empathy-the ability to share in and make inferences about how other people feel. This impairment negatively impacts social interactions and relationships. Accumulating evidence indicates that emotional empathy depends on coordinated functions of orbitofrontal cortex, anterior insula, anterior cingulate, temporal pole, and amygdala, bu… Show more

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Cited by 111 publications
(92 citation statements)
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“…The corticospinal tracts have not been reported to have a specific role in memory or executive function and control voluntary movement. The uncinate fasciculus control emotions[34]. The degree of change in DTI metrics were consistent with the degree of improvement seen in some other medical conditions[22, 35].…”
Section: Discussionsupporting
confidence: 60%
“…The corticospinal tracts have not been reported to have a specific role in memory or executive function and control voluntary movement. The uncinate fasciculus control emotions[34]. The degree of change in DTI metrics were consistent with the degree of improvement seen in some other medical conditions[22, 35].…”
Section: Discussionsupporting
confidence: 60%
“…In this study, we have focused our investigation on the connectional anatomy of the subjective empathy network with the rationale that only one lesion study (Oishi et al, 2015) have to date rely empathy functioning to white matter connectivity. To shed light on this matter, we processed self-reports of empathy, obtained from a large group of homogenous glioma patients, by combining voxelwise and tractwise analyses.…”
Section: Discussionmentioning
confidence: 99%
“…In a population of schizophrenic patients, certain dimensions of empathy as indexed by the interpersonal reactivity index (IRI; Davis, 1983) were shown to differentially correlate with FA measurements in white matter fibres belonging to the left inferior fronto-occipital fasciculus and the splenium of the corpus callosum (Fujino et al, 2014). Remarkably, a causal link was found between damage to the right uncinate fasciculus and emotional empathy in a sample of 30 patients with stroke injury in a very recent study (Oishi et al, 2015). Aside from these studies, the relationships between disturbance in empathic functioning and damage to white matter connectivity has not been yet explored in a large-scale neuropsychological population.…”
Section: Introductionmentioning
confidence: 93%
“…Prominent subcortical fiber bundles, including the uncinate and the arcuate fascicle, connect the insula to the frontoorbital and temporopolar and temporomesial regions. Damage to the opercula or fiber might have impacted the performance on empathy scales in some patients (Martino et al, 2015;Oishi et al, 2015). Furthermore, a larger sample size would have allowed for comparisons according to the particular location of the insular-cortex lesions (anterior vs. posterior insular cortex), which could be of special interest given the functional segregation within the insular cortex revealed by functional imaging and intracerebral electrical stimulation studies (Kurth, Zilles, Fox, Laird, & Eickhoff, 2010).…”
Section: Limitationmentioning
confidence: 99%