Critical time window of fenvalerate-induced fetal intrauterine growth restriction in mice

Guo, Ce; Yang, Yang; Shi, Meng-Xing; Wang, Bo; Liu, Ji-Jie; D, Xu; Meng, Xiu-Hong

doi:10.1016/j.ecoenv.2019.01.054

Cited by 27 publications

(4 citation statements)

References 35 publications

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“…Hadden et al (2017) reported that TPH1-KO mice had a larger number of TUNEL positive cells in placentas and a lower proliferation rate of embryos, relative to wild-type counterparts . In this study, we observed that inulin increased the ratio of labyrinth area/junctional area, thus constituting a greater surface for oxygen and nutrient exchange . We also found that the gene expression of neutral amino acids transporter Slc 38 a 2 was increased in the placenta of the inulin group.…”

Section: Discussionsupporting

confidence: 67%

“…75 In this study, we observed that inulin increased the ratio of labyrinth area/ junctional area, thus constituting a greater surface for oxygen and nutrient exchange. 76 We also found that the gene expression of neutral amino acids transporter Slc38a2 was increased in the placenta of the inulin group. The placenta is a major extrapineal source of melatonin during pregnancy.…”

Section: ■ Discussionmentioning

confidence: 53%

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Maternal Long-Term Intake of Inulin Improves Fetal Development through Gut Microbiota and Related Metabolites in a Rat Model

Xie

Huang

Wang

et al. 2022

J. Agric. Food Chem.

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Adequate dietary fiber intake during gestation is critical for maternal–fetal health. This experiment aims to uncover the impacts of maternal long-term intake of inulin on fetal development and its underlying mechanism. Eighty female Sprague-Dawley rats were randomly assigned to two groups receiving either a fiber-free diet or an inulin diet (inulin) for three parities. On the 19th day of pregnancy in the third parity, blood, intestinal, placental, and colonic digesta samples were collected. Results showed that maternal intake of inulin significantly decreased the within-litter birth weight variation in parities 2 and 3. Inulin intake modified the gut microbiome profiles and elevated the colonic contents of short chain fatty acids (propionate and butyrate). Inulin decreased the serotonin (5-HT) concentration in the colon, whereas it increased the 5-HT concentrations in serum and placenta and the number of 5-HT+ enterochromaffin cells in the colon. The protein expression of melatonin-synthesizing enzyme (arylalkylamine N-acetyltransferase) and the melatonin concentration in the placenta were also increased by inulin. Inulin improved the placental redox status and nutrient transport. These findings indicated that maternal long-term intake of inulin improves fetal development by altering the intestinal microbiota and related metabolites in rats.

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Section: Discussionsupporting

confidence: 67%

Section: ■ Discussionmentioning

confidence: 53%

Maternal Long-Term Intake of Inulin Improves Fetal Development through Gut Microbiota and Related Metabolites in a Rat Model

Xie

Huang

Wang

et al. 2022

J. Agric. Food Chem.

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“…Notably, deviations in the anticipated embryonic stage are known to occur within littermates, due to variable time of conception, implantation time and nutrient disparity (Croy et al, 2014; Kalev-Altman et al, 2020; Wong et al, 2015). However, variations in the developmental kinetics of individual mouse embryos within the same mother were also reported to occur due to maternal exposure to different environmental pollutants (Althali et al, 2019; Guo et al, 2019; Müller et al, 2018; Tao et al, 2022). Hence, it was necessary to further determine whether the observed growth differences were random or associated with maternal exposure to CBZ.…”

Section: Resultsmentioning

confidence: 99%

Maternal exposure to environmental levels of carbamazepine induces mild growth retardation in mouse embryos

Douek-Maba

Kalev-Altman

Mordehay

et al. 2023

Preprint

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As chemical pollution is constantly increasing, the impact on the environment and public health must be investigated. This study focuses on the anticonvulsant drug carbamazepine (CBZ), which is ubiquitously present in the environment. Due to its physicochemical properties and stability during wastewater treatment, CBZ is detected in reclaimed wastewater, surface water and groundwater. In water-scarce regions heavily relying on treated wastewater for crop irrigation, CBZ is detected in arable land, produce and even in humans consuming crops irrigated with recealimed wastewater. Although environmental levels of CBZ are very low, risks associated with unintentional exposure to CBZ are essential to be revealed. In perinatal medicine, CBZ is a teratogen; its prescription to pregnant women increases the risk for fetal malformations. This raises the concern of whether environmental exposure to CBZ may also impact embryogenesis. Studies in zebrafish and chick embryos or in cell culture have indicated negative outcomes upon exposure to low CBZ levels. Yet, these systems do not recapitulate the manner by which human fetuses are exposed to pharmaceuticals via maternal uptake. Here, we employed the mouse model to determine whether maternal exposure to environmental-relevant doses of CBZ will impact embryonic development. No effects on fertility, number of gestation sacs, gross embryonic malformations or fetal survival were detected. Yet, embryos were growth-delayed compared to controls (p=0.0011), as manifested in lower embryonic stage and somite number, earlier morphological features and reduction in mitotically-active cells. This study provides the first evidence for the effect of environmental concentration of CBZ on the developmental kinetics of maternally-exposed mammalian embryos. While the developmental delay was relatively modest, its consistency in high number of biological replicates, together with the known implication of developmental delay on post-natal health, calls for further in-depth risk analyses to reveal the effects of pharmaceuticals released to the environment on public health.

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“…[23][24][25] Also, after prenatal exposure in mice, fenvalerate was found to affect neurodevelopment in male offspring and fetal intrauterine growth restriction and exhibited enantio-selective toxicity on the earthworms. [26][27][28] Moreover, studies conducted on fenvalerate-exposed workers suggested that this insecticide or its transformation products induced morphologic abnormality and genotoxic defects of spermatozoa. 29 In the present work, we investigated the fenvalerate photolysis by proton nuclear magnetic resonance ( 1 H NMR), 13 C NMR, and GC-MS, using a solar light simulator as an irradiation source.…”

Section: Introductionmentioning

confidence: 99%

Photodegradation study of the fenvalerate insecticide by 1H NMR, 13C NMR, and GC-MS and structural elucidation of its transformation products

Thiaré

Diaw

Mbaye

et al. 2022

Maced. J. Chem. Chem. Eng.

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The photolysis of fenvalerate, a pyrethroid insecticide, was studied in acetonitrile by 1H nuclear magnetic resonance (NMR) and 13C NMR to identify the site of bond cleavage and gas chromatography-mass spectrometry (GC-MS) to establish the chemical structure of fenvalerate photoproducts. Ultraviolet (UV) irradiation of fenvalerate solutions was performed for 18 h with a solar light simulator, and the photolysis reaction obeyed first-order kinetics. Photolysis half-life time (t1/2) values ranged between 15.25 and 21.63 h (mean photodegradation percentage = 51.7 %) for 1H NMR and between 4.55 and 8.06 h (mean photodegradation percentage > 80 %) for 13C NMR. We observed five sites of bond cleavage, namely carbonyl-tertiary carbon, tertiary carbon-tertiary carbon, carbonyl-oxygen, carboxyl-tertiary carbon, and aromatic carbon-tertiary carbon, yielding photoproducts formation. GC-MS was associated with 1H NMR and 13C NMR to obtain a complete photodegradation mechanism. Before UV irradiation, two chromatogram peaks were obtained, due to the two fenvalerate isomers. Under irradiation, both peaks decreased, and new peaks appeared, corresponding to photoproduct formation. After a 12- to 13-h irradiation, 99.39 % of fenvalerate was degraded with a mean rate constant of 0.305 h–1. The chemical structure of the formed photoproducts was identified, either by using the National Institute of Standards and Technology (NIST) mass spectral database or by interpreting the mass spectra. Finally, a detailed mechanism was proposed for fenvalerate photodegradation.

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Critical time window of fenvalerate-induced fetal intrauterine growth restriction in mice

Cited by 27 publications

References 35 publications

Maternal Long-Term Intake of Inulin Improves Fetal Development through Gut Microbiota and Related Metabolites in a Rat Model

Maternal Long-Term Intake of Inulin Improves Fetal Development through Gut Microbiota and Related Metabolites in a Rat Model

Maternal exposure to environmental levels of carbamazepine induces mild growth retardation in mouse embryos

Photodegradation study of the fenvalerate insecticide by 1H NMR, 13C NMR, and GC-MS and structural elucidation of its transformation products

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