Crizotinib prodrug micelles co-delivered doxorubicin for synergistic immunogenic cell death induction on breast cancer chemo-immunotherapy

Liang, Qiangwei; Yang, Lan; Li, Yifan; Cao, Yongjin; Li, Juan; Liu, Yanhua

doi:10.1016/j.ejpb.2022.07.006

Cited by 16 publications

(10 citation statements)

References 25 publications

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“…Treg cells are an essential type of immunosuppressive cell in the body that inhibit the function of effector T cells [ 115 , 116 , 117 ]. In clinics, cyclophosphamide chemotherapeutic drugs are frequently used to inhibit the Treg cells to promote anti-tumor immunity [ 118 ]. In order to explore the mechanistic properties of Treg cells after the addition of these drugs, Qi S et al constructed a fluorescent-labeled transgenic mouse and skin window chamber model for observing the dynamics of Treg cells using in vivo imaging technology [ 82 ].…”

Section: Applications Of In Vivo Imaging In Studying Tumor Immunotherapymentioning

confidence: 99%

Applications of Intravital Imaging in Cancer Immunotherapy

Deng,

Hao,

et al. 2024

Bioengineering

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Currently, immunotherapy is one of the most effective treatment strategies for cancer. However, the efficacy of any specific anti-tumor immunotherapy can vary based on the dynamic characteristics of immune cells, such as their rate of migration and cell-to-cell interactions. Therefore, understanding the dynamics among cells involved in the immune response can inform the optimization and improvement of existing immunotherapy strategies. In vivo imaging technologies use optical microscopy techniques to visualize the movement and behavior of cells in vivo, including cells involved in the immune response, thereby showing great potential for application in the field of cancer immunotherapy. In this review, we briefly introduce the technical aspects required for in vivo imaging, such as fluorescent protein labeling, the construction of transgenic mice, and various window chamber models. Then, we discuss the elucidation of new phenomena and mechanisms relating to tumor immunotherapy that has been made possible by the application of in vivo imaging technology. Specifically, in vivo imaging has supported the characterization of the movement of T cells during immune checkpoint inhibitor therapy and the kinetic analysis of dendritic cell migration in tumor vaccine therapy. Finally, we provide a perspective on the challenges and future research directions for the use of in vivo imaging technology in cancer immunotherapy.

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Section: Applications Of In Vivo Imaging In Studying Tumor Immunotherapymentioning

confidence: 99%

Applications of Intravital Imaging in Cancer Immunotherapy

Deng,

Hao,

et al. 2024

Bioengineering

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“…Depending on the complexity of the immunosuppressive TME and the low immunogenicity of tumor cells, the sensitivity to tumor chemotherapy can be reduced, resulting in limited clinical efficacy. Therefore, a more efficient treatment strategy is urgently needed ( 98 ). The immune response is the basis of ICD.…”

Section: Uxt and Immunitymentioning

confidence: 99%

UXT at the crossroads of cell death, immunity and neurodegenerative diseases

Han

Wang

et al. 2023

Front. Oncol.

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The ubiquitous expressed transcript (UXT), a member of the prefoldin-like protein family, modulates regulated cell death (RCD) such as apoptosis and autophagy-mediated cell death through nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), P53, P62, and methylation, and is involved in the regulation of cell metabolism, thereby affecting tumor progression. UXT also maintains immune homeostasis and reduces proteotoxicity in neuro-degenerative diseases through selective autophagy and molecular chaperones. Herein, we review and further elucidate the mechanisms by which UXT affects the regulation of cell death, maintenance of immune homeostasis, and neurodegenerative diseases and discuss the possible UXT involvement in the regulation of ferroptosis and immunogenic cell death, and targeting it to improve cancer treatment outcomes by regulating cell death and immune surveillance.

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“…Epithelial cells that line the granular ducts (85%) or lobules (15%) in breast tissues play an important role in breast cancer occurrence . In the initial stage, cancerous cell growth is restricted to the ducts or lobules, a state where cancer does not cause any symptoms and has limited potential to spread (metastasis) . Eventually, cancer cells would invade the surrounding breast tissues and spread to nearby lymph nodes (regional metastasis) or other organs (distant metastasis) .…”

Section: Introductionmentioning

confidence: 99%

“…In this case, cancer treatment becomes challenging as various treatments are required. In fact, breast cancer treatment is generally highly effective, especially when it is detected and treated early . Standard breast cancer treatment usually involves surgical removal, radiation therapy, and medication (hormonal therapy, chemotherapy, or targeted immunotherapies). , These therapies have the potential to inhibit tumor cell growth and prevent metastasis. − …”

Section: Introductionmentioning

confidence: 99%

“… 1 In the initial stage, cancerous cell growth is restricted to the ducts or lobules, a state where cancer does not cause any symptoms and has limited potential to spread (metastasis). 2 Eventually, cancer cells would invade the surrounding breast tissues and spread to nearby lymph nodes (regional metastasis) or other organs (distant metastasis). 3 In this case, cancer treatment becomes challenging as various treatments are required.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Folic Acid-Functionalized DPLA-co-PEG Nanomicelles for the Targeted Delivery of Letrozole

Rostami

Gomari

Abdouss

et al. 2023

ACS Appl. Bio Mater.

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An effective treatment for hormone-dependent breast cancer is chemotherapy using cytotoxic agents such as letrozole (LTZ). However, most anticancer drugs, including LTZ, are classified as class IV biopharmaceuticals, which are associated with low water solubility, poor bioavailability, and significant toxicity. As a result, developing a targeted delivery system for LTZ is critical for overcoming these challenges and limitations. Here, biodegradable LTZ-loaded nanocarriers were synthesized by solvent emulsification evaporation using nanomicelles prepared with dodecanol-polylactic acid-co-polyethylene glycol (DPLA-co-PEG). Furthermore, cancer cell-targeting folic acid (FA) was conjugated into the nanomicelles to achieve a more effective and safer cancer treatment. During our investigation, DPLA-co-PEG and DPLA-co-PEG-FA displayed a uniform and spherical morphology. The average diameters of DPLA-co-PEG and DPLA-co-PEG-FA nanomicelles were 86.5 and 241.3 nm, respectively. Our preliminary data suggest that both nanoformulations were cytocompatible, with ≥90% cell viability across all concentrations tested. In addition, the amphiphilic nature of the nanomicelles led to high drug loading and dispersion in water, resulting in the extended release of LTZ for up to 50 h. According to the Higuchi model, nanomicelles functionalized with FA have a greater potential for the controlled delivery of LTZ into target cells. This model was confirmed experimentally, as LTZ-containing DPLA-co-PEG-FA was significantly and specifically more cytotoxic (up to 90% cell death) toward MCF-7 cells, a hormone-dependent human breast cancer cell line, when compared to free LTZ and LTZ-containing DPLA-co-PEG. Furthermore, a half-maximal inhibitory concentration (IC50) of 87 ± 1 nM was achieved when MCF-7 cells were exposed to LTZ-containing DPLA-co-PEG-FA, whereas higher doses of 125 ± 2 and 100 ± 2 nM were required for free LTZ and LTZ-containing DPLA-co-PEG, respectively. Collectively, DPLA-co-PEG-FA represents a promising nanosized drug delivery system to target controllably the delivery of drugs such as chemotherapeutics.

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Crizotinib prodrug micelles co-delivered doxorubicin for synergistic immunogenic cell death induction on breast cancer chemo-immunotherapy

Cited by 16 publications

References 25 publications

Applications of Intravital Imaging in Cancer Immunotherapy

Applications of Intravital Imaging in Cancer Immunotherapy

UXT at the crossroads of cell death, immunity and neurodegenerative diseases

Synthesis and Characterization of Folic Acid-Functionalized DPLA-co-PEG Nanomicelles for the Targeted Delivery of Letrozole

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