The current supply chain vulnerability has become a prominent factor affecting the stable development of the economy in various countries and is a significant issue with overall and long-term significance. This study constructs a network model to measure the vulnerability and identify key influencing factors in the LED lighting industry supply chain based on the entropy-CRITIC–ISM method. By reviewing literature and using expert interviews, an indicator system for measuring the vulnerability of the LED lighting industry supply chain was constructed. The relative weights of each evaluation indicator were determined using the entropy-CRITIC method, identifying the main factors influencing supply chain vulnerability. Based on the ISM model, the structure of the vulnerability of the LED lighting industry supply chain is revealed and presented in a hierarchical-directed topological graph. The results indicate that the ratio of key equipment suppliers from overseas, the spatial aggregation degree of the supply chain, the growth rate of LED lighting industry manufacturers, and the international market share of LED lighting industry products are deep-seated factors influencing the vulnerability of the LED lighting industry supply chain. The conclusions provide a quantitative method for objectively understanding the vulnerability of the LED lighting industry supply chain and offer specific policy references for filling the gaps and strengthening the industrial basic capabilities of the LED lighting industry