Cross-cultural Adaptation and Multi-centric Validation of the Motor Function Measure Chinese Version (MFM-32-CN) for Patients with Neuromuscular Diseases

Huang, Meihuan; Cao, Jianguo; Sun, Jian; Li, Wenzhu; Qin, Lun Xiu; Li, Hui; Zhai, Chun; Huang, Wei‐Ping; Gui, Tangya; Zhang, Kuibiao; Wang, Jian; Vuillerot, Carole; Wang, Yujuan; Dai, Mengying

doi:10.1080/17518423.2019.1642413

Cited by 5 publications

(16 citation statements)

References 24 publications

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“…Hypothesis testing for construct and content validity was evaluated in seven instruments and structural validity was evaluated in six 16,35,44,47–49,53,54,57,63,69,70–72 . Responsiveness was measured in only three instruments 50,52,73,74 and examination of criterion validity was made in only two 67,69 . Measurement error was reported in only one instrument 69 and none of the five studies that translated and carried out cross‐cultural adaptation of the instruments reported cross‐cultural validity and/or measurement invariance.…”

Section: Resultsmentioning

confidence: 99%

“…16,35,44,[47][48][49]53,54,57,63,69,[70][71][72] Responsiveness was measured in only three instruments 50,52,73,74 and examination of criterion validity was made in only two. 67,69 Measurement error was reported in only one instrument 69 and none of the five studies that translated and carried out cross-cultural adaptation of the instruments reported crosscultural validity and/or measurement invariance. The instruments with the highest number of measurement properties tested were the MFM scale and PUL.…”

Section: Summary Of the Studies Included In The Reviewmentioning

confidence: 99%

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Instruments to assess upper‐limb function in children and adolescents with neuromuscular diseases: a systematic review

Davoli¹,

Cardoso²,

Silva³

et al. 2021

Develop Med Child Neuro

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Aim To synthesize clinical and scientific evidence regarding the instruments available to assess upper‐limb function in paediatric patients with neuromuscular disease (NMD). Method This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses and COnsensus‐based Standards for the selection of health Measurement INstruments (COSMIN) guidelines (Prospective Registry of Systematic Reviews no. CRD42020140343). Two independent reviewers searched the PubMed/MEDLINE, LILACS, Embase, and Scopus databases. Inclusion criteria were cross‐sectional or longitudinal studies or randomized controlled trials that used scales or questionnaires to assess upper‐limb function in paediatric patients with NMDs. The COSMIN Risk of Bias checklist and criteria for good measurement properties were applied to assess the methodological quality of the instruments. Results In total, 34 articles and 12 instruments were included. The Brooke Upper Extremity (n=16) and Performance of Upper Limb (PUL) (n=12) instruments were the most used tools. The PUL and Duchenne muscular dystrophy (DMD) Upper Limb patient‐reported outcome measures (PROMs) tested more measurement properties and provided higher methodological quality scores for patients with DMD. Likewise, the Revised Upper Limb Module (RULM) was the most suitable instrument for patients with spinal muscular atrophy. No instrument has been devised to assess upper‐limb function in patients with Charcot–Marie–Tooth disease and no other disease‐specific instruments were found. Interpretation The PUL, DMD Upper Limb PROM, and RULM are the most suitable instruments to assess upper‐limb function in the two most prevalent paediatric NMDs. The identified gaps and methodological flaws of the available instruments indicate a need to develop high‐quality instruments to assess other types of paediatric NMDs. The most suitable observer–rater instrument to assess upper‐limb function in Duchenne muscular dystrophy (DMD) is the Performance of Upper Limb. The most suitable observer–rater instrument to assess upper‐limb function in spinal muscular atrophy is the Revised Upper Limb Module. The DMD Upper Limb patient‐reported outcome measure is recommended to assess the upper‐limb performance of patients with DMD. Literature gaps and methodological flaws indicate the need to develop high‐quality instruments to assess other types of paediatric neuromuscular disease.

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Section: Resultsmentioning

confidence: 99%

Section: Summary Of the Studies Included In The Reviewmentioning

confidence: 99%

Instruments to assess upper‐limb function in children and adolescents with neuromuscular diseases: a systematic review

Davoli¹,

Cardoso²,

Silva³

et al. 2021

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

“…6 very good methodological studies calculated Cronbach's alpha for MFM total score: 1 study for MFM20's, 4 studies for MFM32. [7,8,14,[18][19][20]. Five studies (4 very good methodological studies and 1 doubtful methodological study) calculated Cronbach's alpha for MFM's subscales [7,8,[19][20][21].…”

Section: Internal Consistencymentioning

confidence: 99%

Psychometric Characteristics of the Motor Function Measure in Neuromuscular Diseases: A Systematic Review1

Ribault

Rippert

Jain

et al. 2023

JND

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Background: Recent pharmaceutical breakthroughs in neuromuscular diseases may considerably change the prognosis and natural history these diseases. The ability to measure clinically relevant outcomes such as motor function is critical for the assessment of therapeutics and the follow up of individuals. The Motor Function Measure (MFM) is a quantitative scale designed to measure motor function in adult and children with neuromuscular disease (NMD). Objective: The objective of this study is to assess the quality and level of evidence of the MFM’s published measurement properties by completing a systematic review of the validation and responsiveness studies of the MFM20 (a 20-item version of MFM adapted for children 2 to 6 years of age) and the MFM32 (the original 32 item version), in all NMDs and in specific diseases. Methods: A search for MFM responsiveness and MFM validation studies was completed in February 2023 in EMBASE, MEDLINE, SCOPUS and Web of Science databases. The PRISMA guidelines and the COSMIN manual for systematic reviews were followed for databases searches, articles screening and selection, study quality and measurement properties evaluation. Results: 49 studies were included in analysis. In studies including individuals with all NMDs, MFM’s internal consistency, reliability, convergent validity, construct validity and responsiveness were rated as sufficient with a high quality of evidence. Structural validity was rated sufficient with a moderate quality of evidence In SMA in particular, MFM’s reliability, internal consistency, convergent validity, discriminant validity and responsiveness are sufficient with a high quality of evidence. More studies would be required to assess specific measurement properties in different diseases. MFM32’s minimal clinically relevant difference has been defined between 2 and 6%. Conclusion: MFM’s structural validity, internal consistency, reliability, construct validity, convergent validity and responsiveness have been verified with moderate to high level of evidence.

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“…In previous studies, our research team tested the psychometric properties of the Motor Function Measure in patients with Duchenne muscular dystrophy using traditional psychometric methods. 11, 12 The instrument has been shown to be a valid, reproducible and responsive clinical assessment tool for this group of patients. Traditional psychometric methods have been broadly applied to evaluate rating scales’ measurement properties.…”

Section: Introductionmentioning

confidence: 99%

“…These critical limitations can be addressed by applying modern psychometric methods, such as Rasch analysis based on Rasch measurement theories. 14 To date, although several classical reliability and validity analyses 8, 11, 12 have been performed on the Motor Function Measure in patients with Duchenne muscular dystrophy, a comprehensive analysis using a Rasch measurement theory is still lacking. In light of the clinical benefits of new psychometric methods, this study aimed to analyze the 32-item Motor Function Measure in a cohort of ambulatory patients with Duchenne muscular dystrophy using Rasch analyses.…”

Section: Introductionmentioning

confidence: 99%

Rasch analysis of the 32-item motor function measure in ambulant patients with Duchenne muscular dystrophy

et al. 2022

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Objective This study analyzed the 32-item Motor Function Measure in a cohort of ambulatory patients with Duchenne muscular dystrophy using Rasch measurement methods. Design This is a psychometric study. Setting Rehabilitation centre of a large public children's hospital in Shenzhen, China. Participants Data from 176 genetically confirmed ambulant patients with Duchenne muscular dystrophy (mean age 7.3 years, SD 2.3 years, range 3.1–13.1 years) were analyzed. Results Rasch analyses supported the Motor Function Measure domain D1 as a reliable (person reliability = 0.88, person separation index = 2.71) and valid (acceptable targeting, little misfit, minimal category disordering) measure in ambulant patients with Duchenne muscular dystrophy. Remodelling the domain D1 by collapsing item 25 from 4 to 3 response categories addressed the problematic disordered thresholds, resulting in a rebuilt domain D1 with enhanced measurement properties. However, findings for domains D2 and D3 did not fulfil most Rasch model expectations. There were disordered thresholds for most items in domains D2 and D3, with low reliability coefficients, item mistargeting and misfit, and large ceiling effects. Conclusion Rasch analyses confirmed that the Motor Function Measure domain D1 was reliable and valid and provided a unidimensional measure for motor function in ambulant Duchenne muscular dystrophy patients. Accuracy of measurement had been enhanced through remodelling, and a rebuilt domain D1 with category collapsing for item 25 was proposed. The analysis revealed multiple limitations of the domains D2 and D3 that certain essential psychometrics were poorly met and, therefore, should be used with caution in this patient group.

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Cross-cultural Adaptation and Multi-centric Validation of the Motor Function Measure Chinese Version (MFM-32-CN) for Patients with Neuromuscular Diseases

Cited by 5 publications

References 24 publications

Instruments to assess upper‐limb function in children and adolescents with neuromuscular diseases: a systematic review

Instruments to assess upper‐limb function in children and adolescents with neuromuscular diseases: a systematic review

Psychometric Characteristics of the Motor Function Measure in Neuromuscular Diseases: A Systematic Review1

Rasch analysis of the 32-item motor function measure in ambulant patients with Duchenne muscular dystrophy

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