Cross-Linked Chitosan Bead Supported Copper Complex in Water as a Green and Efficient Catalytic Protocol for Ullmann Reaction

Lü, Xiaomei; Ruan, Jiancheng; Chen, Xinzhi; Qian, Chao

doi:10.6023/cjoc201901018

Cited by 3 publications

(1 citation statement)

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“…Among these materials, chitosan (CS) has been frequently applied as a catalyst support material, as related to its high affinity to metals, water-soluble character, and large number of amino groups, which make it suitable for chemical modification [35][36][37]. Chitosan-supported Cu catalysts have been successfully applied for Ullmann-type heteroarylations [38], but only a few examples have been reported for the utilization of functionalized chitosan materials in these kinds of reactions [39,40]. Recently, Ge et al synthesized a functionalized chitosan-supported copper complex to be applied as a catalyst in the Ullmann-type N-arylation reaction [41].…”

Section: Copper-based Catalystsmentioning

confidence: 99%

On the Current Status of Ullmann-Type N-Arylation Reactions Promoted by Heterogeneous Catalysts

Mastalir

Molnár

2023

Inorganics

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Ullmann-type C–N heterocoupling reactions have been applied for the syntheses of N-arylated amines. In the past decade, transition metal-catalyzed N-arylations have been recognized as particularly efficient procedures for the preparation of nitrogen-containing aromatic systems. These reactions typically carried out under optimized conditions, have also been found to be suitable for the synthesis of complex molecules with other functional groups, including natural products, drugs, or pharmaceuticals. Most importantly, copper-catalyzed N-arylations have been studied and employed in the total synthesis of biologically active compounds. The construction of fused N-heterocyclic compounds also remained the subject of extensive research because of their potential applications in drug discovery and the development of functional materials. The aim of this review is to summarize the recent progress in the synthetic applications of Ullmann-type N-arylation reactions performed in heterogeneous systems. In particular, the utilization of copper and palladium species immobilized on various support materials, modified by surface functionalization, has been discussed and evaluated.

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