Cross-Protection Mechanism Between Sindbis and Semliki Forest Viruses in Mice

Brand, Orville M.; Allen, William P.

doi:10.21236/ad0449729

Cited by 2 publications

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“…Although it is established that there is no cross neutralizing antibody between Sindbis virus and SFV (Brand & Allen, 1964), some antigenic relationships do exist, such as those which elicit antibody that inhibits virus haemagglutination (Brand & Allen, 1964). We therefore z. LATIF AND OTHERS * Titre = extrapolation from triplicate determinations of the reciprocal of antiserum dilutions reducing the number of SFV plaques by 50 ~.…”

Section: Antibody Responsementioning

confidence: 99%

Cross Protection among Togaviruses in Nude Mice and Littermates

Latif

Gates

Wust

et al. 1979

Journal of General Virology

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SUMMARYAfter immunization with Sindbis virus, T-cell deficient nude mice, compared to normal littermates, were equally protected against challenge with Sindbis virus. However, the nude mice showed about one-tenth the protection observed with normal littermates after challenge with Semliki Forest virus at a dose of too LDs0. This is consistent with our previous interpretation that sensitized T-cell populations play a major role in cross protection between the two togaviruses. The remaining low level of specific cross protection in nude mice (detectable only at a challenge dose of IO LDs0 ) could not be attributed to an anamnestic response of neutralizing antibody to the challenge virus or to an effective antibody-dependent, complement-mediated cytolysis of infected cells in vivo. Other possible compensatory mechanisms to explain the low level of specific cross protection in nude mice are discussed.

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Section: Antibody Responsementioning

confidence: 99%

Cross Protection among Togaviruses in Nude Mice and Littermates

Latif

Gates

Wust

et al. 1979

Journal of General Virology

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Cross-protection Correlates with Delayed Antibody Formation to Challenge Virus after Immunization with Sindbis Virus

Smith-Owirodu

Wust

Gates

et al. 1980

Journal of General Virology

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SUMMARYMice immunized with Sindbis virus, strains HR (heat-resistant) or AR339, by a dual injection given intracerebrally (i.c.) and intraperitoneally (i.p.) at day zero, were cross-protected from challenge at day IO with Semliki Forest virus (SFV). Neutralizing and haemagglutination-inhibition antibodies to Sindbis are detected in high titre by day 6 after immunization but no cross-reacting antibodies to SFV were found up to day 42. Immunized mice that were challenged with SFV showed an 8 to IO day delay in the appearance of antibody to SFV compared to mice that were sham-inoculated. Thus, cross-protection in Sindbis-immunized animals was correlated with a temporary suppression of antibody formation to the challenge virus (SFV), while the appearance of high titre antibody to SFV in shamimmunized mice after challenge with SFV did not protect.

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Cross-Protection Mechanism Between Sindbis and Semliki Forest Viruses in Mice

Cited by 2 publications

References 0 publications

Cross Protection among Togaviruses in Nude Mice and Littermates

Cross Protection among Togaviruses in Nude Mice and Littermates

Cross-protection Correlates with Delayed Antibody Formation to Challenge Virus after Immunization with Sindbis Virus

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