Cross-Reactivity between &lt;i&gt;Aspergillus fumigatus&lt;/i&gt; and &lt;i&gt;Penicillium&lt;/i&gt;

Brouwer, Jaap

doi:10.1159/000237283

Cited by 24 publications

(18 citation statements)

References 21 publications

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“…Inhibition experiments showed strong crossreactivity within Penicillium species, but also between Penicillium species and A. fumigatus, as described earlier [11]. We conclude that IgE-mediated occupational asthma may occur in dry sausage packers with exposure to moulds which are used for sausage refinement.…”

Section: Discussionsupporting

confidence: 85%

Occupational Immunoglobulin E-Mediated Asthma due to <i>Penicillium camemberti</i> in a Dry-Sausage Packer

Merget

Sander²,

Rozynek³

et al. 2006

Respiration

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A 62-year-old female sausage packer reported progressive work-related asthma, rhinitis and contact urticaria after contact to dry sausages refined by moulds. Whereas skin prick tests with commercial mould extracts were negative, the patient showed weak skin sensitization to a cultivated mould sample from a dry sausage. Specific immunoglobulin E antibodies to various moulds were demonstrated by ImmunoCAP and antibodies to the cultivated mould sample were demonstrated by enzyme allergosorbent test. The mould was identified by pheno- and genotyping as Penicillium camemberti. Five atopic controls did not show sensitization with the same tests. Crossreactivity of P. camemberti and Penicillium notatum was shown by enzyme allergosorbent inhibition tests. Although no challenge tests were considered due to the patient’s airway obstruction, a diagnosis of allergic occupational asthma was made. We conclude that immunoglobulin E-mediated allergic occupational asthma due to moulds may occur in dry sausage packers.

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Section: Discussionsupporting

confidence: 85%

Occupational Immunoglobulin E-Mediated Asthma due to <i>Penicillium camemberti</i> in a Dry-Sausage Packer

Merget

Sander²,

Rozynek³

et al. 2006

Respiration

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“…The existence of cross-reactivity between various fungi could be determined by assays such as CAP inhibition [24]. Cross-reactivity between A. fumigatus and Penicillium using similar inhibition methods demonstrated that the binding to Penicillium of IgE antibodies in sera from patients with allergic bronchopulmonary aspergillosis could be inhibited by A. fumigatus almost as effectively as by Penicillium [39]. By using affinity-purified antibodies and a sensitive and quantitative assay with untreated antigens [40], the cross-reactivity between Stachybotrys, Aspergillus and Penicillium was determined to be approximately 10%, which is lower than previously believed.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Serum Levels of Fungi-Specific Immunoglobulin E in Patients with Allergic Diseases

Chang

Lee

Yang

et al. 2010

Int Arch Allergy Immunol

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Background: Atopic patients are exceptionally sensitive to airborne allergens. Sensitization to fungal allergens may be associated with respiratory allergic disease (RAD) and atopic dermatitis (AD). This study investigates the relationship between sensitization to different fungal allergens and the clinical manifestations of atopic disease. Methods: We retrospectively reviewed the medical records of atopic patients from the National Taiwan University Hospital from 2004 to 2009. A total of 133 atopic patients were found who were sensitive to at least 1 of the 3 most common fungi (Candida albicans, Aspergillus fumigatus, Penicillium chrysogenum) in Taiwan and were enrolled in the study. These patients were further divided into subgroups of isolated AD, isolated RAD and AD + RAD. The association between sensitization to fungi and allergic disease was analyzed by logistic regression analysis. Results: The sensitization rate to Candida-specific IgE was 81.2%, followed closely by Aspergillus at 69.2% and Penicillium at 63.2%. Isolated AD was the most common diagnosis. The levels of specific IgE antibodies against Aspergillus, Candida and Penicillium were highest in patients with isolated AD. Logistic regression revealed that isolated AD was highly associated with sensitization to Candida [odds ratio (OR) 10.45, 95% confidence interval (CI) 2.37–45.9]. In contrast, sensitization to Penicillium (OR 0.34, 95% CI 0.13–0.87)and Candida (OR 0.30, 95% CI 0.10–0.92) showed a negative association with isolated RAD. Conclusions: Fungal sensitization is more closely associated with AD than RAD. Our results suggest that specific sensitization to fungal allergensplays a critical role in the pathogenesis of atopic disease.

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“…The fungus is the only known thermally dimorphic Penicillium species (14) and is immunologically distinct from all other Penicillium species (2,11). Preliminary diagnosis of P. marneffei is established on the basis of a patient's clinical symptoms in conjunction with direct microscopic identification of fission yeasts from tissue specimens (6,20).…”

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confidence: 99%