Cross-reactivity of sIgE to mite and shrimp induced allergies in different age groups and clinical profiles of shrimp sIgE in vegetarians

Abstract

The sensitization to house dust mites (HDMs) and shrimps affects the development of hypersensitivity with an increase in age. Due to the cross-reactivity between shellfish and HDMs, HDMs were considered as the primary sensitizer for shellfish allergy. Thus, vegetarians might be sensitized to shrimp through the inadvertent inhalation of HDMs. Therefore, we assessed the prevalence of shrimp or mite allergy among different age groups and vegetarians. The serum specific-IgE (sIgE) level of HDMs and shrimp in 60 children/adolescence (un-adults), 30 adults, 30 elderly, and four vegetarian adults patients were measured. The sera with sIgE levels greater than 3.5 kUA/L were cross-reactivity examined. We found that HDMs induced higher sIgE than shrimp in un-adults. In contrast, shrimp-induced sIgE was higher in the adults and elderly patients. Moreover, adults were more frequently sensitized to shrimp and mite at the same time compared with the un-adult or elderly groups. The mite-Der p 10 not only displayed high cross-reactivity to the shrimp-Pen a 1 in all age groups and vegetarians but functioned as the major allergen to sensitize un-adults. Overall, the level of mite or shrimp sIgE is influenced by alterations in age, and vegetarians are at risk of shrimp sensitization via cross-reactivity between shrimp and mite.

Immunological Cross-Reactivity Involving Mollusc Species and Mite–Mollusc and Cross-Reactive Allergen PM Are Risk Factors of Mollusc Allergy

“…Moreover, there seem to exist differences in mite–mollusc cross-reactivity depending on climate, a previous study revealed that TM and ubiquitin were responsible for mite–shellfish cross-reactivity from both continental dry and humid climates, while α-actinin and AK are involved in dry- and humid-climate groups, respectively . Shen et al indicated that environmental factors, lifestyles, and dietary habits play critical roles in allergen sensitization, IgE cross-reactivity to mite–shellfish-induced allergies and allergic disease development . As a result of the differences in geographical exposure to dust mite allergens and dietary variables, people living in different climatic zones may have different cross-reactive allergenic components of mite–mollusc.…”

“…46 Shen et al indicated that environmental factors, lifestyles, and dietary habits play critical roles in allergen sensitization, IgE cross-reactivity to mite−shellfish-induced allergies and allergic disease development. 47 As a result of the differences in geographical exposure to dust mite allergens and dietary variables, people living in different climatic zones may have different cross-reactive allergenic components of mite− mollusc.…”

Discovery and characterization of dietary antigens in oral tolerance

“…Immune cross-reactivity has been well documented between allergens (15)(16)(17)(18)(19), but it is unknown whether tolerogenic epitopes also display cross-reactivity. A computational search for homologous peptides revealed orthologs of the epitope recognized by the soy-specific TCR in the genomes of many other plants.…”

Structural Insights on Cross-Reactivity of Mite Allergens with Helminth Proteins

“…Not surprisingly, it has been proposed that the immunological cross-reactivity between allergens from commonly analyzed sources and their helminth-protein orthologs contributes to allergic sensitization associated with the acute and early stages of helminthiasis [25,[27][28][29]. This cross-reactivity has been observed not only with helminth proteins, but also with other invertebrates, which increases the associated problems not only for respiratory allergies, but also for food allergies [30][31][32]. This fact has crucial impacts on allergy diagnosis, as was thoroughly shown by other authors, leading to false positive results in allergy tests [25,27,33].…”