Cross-sectional and longitudinal association between hemoglobin concentration and hypertension

Kim, Na Hyun; Lee, Ju Mi; Kim, Hyeon Chang; Lee, Joo Young; Yeom, Hyungseon; Lee, Jung Hyun; Suh, Il

doi:10.1097/md.0000000000005041

Cited by 22 publications

(17 citation statements)

References 26 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Age, BMI, and hemoglobin level, which showed an increase in progression in both males and females, can be applied as the observed indicator of the progression, even in the normotensive period. In agreement with our results, there is considerable evidence of these factors as a possible risk factors of hypertension [16,[24][25][26][27][28].…”

Section: Discussionsupporting

confidence: 93%

Risk factors of the progression to hypertension and characteristics of natural history during progression: A national cohort study

Hong

Chun

2020

PLoS ONE

View full text Add to dashboard Cite

Background Although the high disease burden that results from cardiovascular complications of hypertension, factors related to the progression to hypertension in the normotensive population are not actively reported. The purpose of this study was to estimate the rate of the progression to hypertension and to reveal the associated risk factors. Methods The study included normotensive participants from the National Health Insurance Service-National Health Screening Cohort, and contained a 10% sample of all adults who received a national health screening test in either 2002 or 2003. At the end of the study in 2015, the patients were divided into two groups based on whether or not they progressed to hypertension. Cox proportional hazard modeling was performed to identify risk factors for progression. Subgroup analysis using logistic regression was employed to reveal factors influencing the different natural history of the progression. Results Among the 75,335 included participants, the progression rate to hypertension was 66.39% (50,013), with an adjusted incidence rate of 8.62 per 100 person-year in the aged 40-64 group and 12.68 in the aged 65 or above group. Age, BMI, hemoglobin, and family history of hypertension and other diseases were related to the progression. Among the progression group, 78.21% (39,116) participants skipped a pre-hypertensive status; this group consisted of older females with lower pulse pressure and more alcohol consumption compared to people who had pre-hypertensive status before the progression.

show abstract

Section: Discussionsupporting

confidence: 93%

Risk factors of the progression to hypertension and characteristics of natural history during progression: A national cohort study

Hong

Chun

2020

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Similar to other studies , risk of pre‐HT and HT increased with increasing Hb levels. The biological mechanisms that explain the link between high Hb level and high BP are unclear, but increased blood viscosity, activation of renin‐angiotensin‐aldosterone system and variation in erythropoietin secretion have all previously been suggested .…”

Section: Discussionsupporting

confidence: 89%

“…Finally, both pre-HT and HT and haemoglobin (Hb) levels affect pregnancy outcomes [17] and there are indications that both SBP and DBP may increase with increasing Hb levels. This association has been widely investigated among Caucasians and Asians but with conflicting results [20][21][22][23][24]. Few studies among Africans have all shown a positive association between increasing Hb with BP [25,26].…”

Section: Introductionmentioning

confidence: 99%

Risk factors of pre‐hypertension and hypertension among non‐pregnant women of reproductive age in northeastern Tanzania: a community based cross‐sectional study

Msemo

Schmiegelow

Nielsen

et al. 2018

Tropical Med Int Health

View full text Add to dashboard Cite

Objectives To determine risk factors of pre‐hypertension and hypertension in a cohort of 1247 rural Tanzanian women before conception. Methods Demographic and socioeconomic data, anthropometric measurements, past medical and obstetric history and other risk factors for pre‐hypertension and hypertension were collected using a structured questionnaire. Multiple logistic regression analysis was used to evaluate the associations between anthropometric indices and other risk factors of pre‐hypertension and hypertension. The predictive power of different anthropometric indicators for identification of pre‐hypertension and hypertension patients was determined by Receiver Operating Characteristic curves (ROC). Results The median (range) age was 28.0 (18–40) years. The age‐standardised prevalences of pre‐hypertension and hypertension were 37.2 (95% CI 34.0–40.6) and 8.5% (95%CI 6.7–10.8), respectively. Of hypertensive patients (n = 98), only 20 (20.4%) were aware of their condition. In multivariate analysis, increasing age, obesity and haemoglobin levels were significantly associated with pre‐hypertension and hypertension. Conclusion Despite a low prevalence of hypertension, over one third of the women had pre‐hypertension. This poses a great challenge ahead as pre‐hypertensive women may progress into hypertension as they grow older without appropriate interventions. Obesity was the single most important modifiable risk factor for pre‐hypertension and hypertension.

show abstract

“…This was consistent with previous reports that low hemoglobin/hematocrit levels in the general population may be associated with a higher risk of ESRD, while hemoglobin-related improvements of outcomes were reduced in people with excessively higher hemoglobin levels [11,12]. This may be partly explained by the association between elevated hemoglobin levels and higher blood pressure [40][41][42] which is a risk factor for CKD progression. In the present study, hemoglobin levels correlated positively to mean atrial pressure (male: r = 0.10, p = 0.004; female: r = 0.12, p < 0.001).…”

Section: Discussionsupporting

confidence: 92%

The Association of Low Hemoglobin Levels with IgA Nephropathy Progression: A Two-Center Cohort Study of 1,828 Cases

Zhu¹,

Liu²,

Yu³

et al. 2020

Am J Nephrol

View full text Add to dashboard Cite

Aim: To investigate the relationship between hemoglobin levels and the progression of IgA nephropathy (IgAN). Methods: In a two-center cohort of 1,828 cases with biopsy-proven IgAN, we examined the association of hemoglobin levels with the primary outcome of a composite of all-cause mortality or kidney failure defined as a 40% decline in eGFR, or ESKD (defined as eGFR <15 mL/min/1.73 m 2 or need for kidney replacement therapy including hemodialysis, peritoneal dialysis, or kidney transplantation), or the outcome of kidney failure, assessed using Cox and logistic regression models, respectively, with adjustment for confounders. Results: At baseline, mean age, eGFR, and hemoglobin levels were 33.75 ± 11.03 years, 99.70 ± 30.40 mL/min/1.73 m 2 , and 123.47 ± 18.36 g/L, respectively. During a median of approximately 7-year follow-up, 183 cases reached the composite outcome. After adjustment for demographic and IgAN-specific covariates and treatments, a lower quartile of hemoglobin was nonlinearly associated with an increased risk of the primary outcome or kidney failure in the Cox proportional hazards models (primary outcome: HR for quartile 3 vs. 4, 1.37; 95% CI, 0.83-2.25; HR for quartile 2 vs. 4, 1.18; 95% CI, 0.68-2.07; HR for quartile 1 vs. 4, 1.91; 95% CI, 1.15-3.17; kidney failure: HR for quartile 3 vs. 4, 1.39; 95% CI, 0.84-2.31; HR for quartile 2 vs. 4, 1.20; 95% CI, 0.68-2.11; HR for quartile 1 vs. 4, 1.83; 95% CI, 1.09-3.07) in the fully adjusted model. Then, hemo-Bin Zhu and Wen-hua Liu contributed equally to this work.

show abstract

Cross-sectional and longitudinal association between hemoglobin concentration and hypertension

Abstract: Supplemental Digital Content is available in the text

Cited by 22 publications

References 26 publications

Risk factors of the progression to hypertension and characteristics of natural history during progression: A national cohort study

Risk factors of the progression to hypertension and characteristics of natural history during progression: A national cohort study

Risk factors of pre‐hypertension and hypertension among non‐pregnant women of reproductive age in northeastern Tanzania: a community based cross‐sectional study

The Association of Low Hemoglobin Levels with IgA Nephropathy Progression: A Two-Center Cohort Study of 1,828 Cases

Contact Info

Product

Resources

About