Cross Sectional and Longitudinal Study of Bone Mineral Content of the Distal Forearm in Adult Premenopausal Women

Abstract

The range of fat corrected distal forearm mineral content (FMC) (at a site which comprises approximately 75% cortical and 25% trabecular bone) and the effect of aging on FMC were determined in normal premenopausal women. In 106 women (mean age 39; range 18-56) the mean FMC was 1.184 (SD 148) g/cm; fat correction increased this to 1.239 (SD 148) g/cm. There were significant correlations between fat corrected FMC and height, weight and BMI (r greater than 0.16; P less than 0.05). In 43 of these women (mean age 35; range 18-51) repeat measurements of FMC were performed. The last measurement was separated from the first by a mean time interval of 27 +/- 3 months. There was no significant change in uncorrected FMC (baseline 1.185 +/- 0.21 g/cm compared with their final measurement 1.182 +/- .020 g/cm; P = 0.51). Fat-corrected FMC (baseline 1.229 +/- .021 g/cm compared with 1.223 +/- .020 g/cm later) tended to decrease although this change was not significant (P = 0.06). Age ranked cusum analysis demonstrated a non-significant fat-corrected rate of change in FMC of -.3% yr in those over 35 years of age (P less than 0.10). This data suggests that if there is any distal forearm bone loss before the menopause it is negligible.

The Effects of Low Dose Norethisterone on Biochemical Variables in Postmenopausal Women

“…The distal forearm bone mineral density was more than 2 standard deviations below the premenopausal mean in all cases [17]. There was a history of peripheral and vertebral fractures in 6 of the cases, peripheral fractures only in 7 and vertebral fractures only in 2.…”

Effects of norethisterone on bone related biochemical variables and forearm bone mineral in post‐menopausal osteoporosis

“…Our series comprises 44 post-menopausal women of mean age 64 years (range 43-87 years), mean years since meno-pause 15 years (range 2-32 years) and mean body weight 61 kg (range 45-78 kg) referred to our metabolic clinic for treatment of varying degrees of osteoporosis. In all patients forearm mineral density was more than two standard deviations below the normal premenopausal mean (Wishart et al, 1991) and 12 had suffered previous vertebral fractures. No patient had previously taken oestrogen or progesterone therapy or any other medication (such as corticosteroids and thiazide diuretics) known to influence calcium metabolism.…”

Bone Mineral Density in French Canadian Women

“…Many cross-sectional [7][8][9][10] and some longitudinal [10,11] studies have reported data on BMD and aging in women. Most investigators agree that bone loss in healthy women varies according to bone type, which may react differently to menopausal status, environmental factors, genetic influences and, above all, aging.…”

“…Even though there have been cross-sectional [7][8][9][10] and longitudinal [10,11] studies designed to assess the change in BMD of women with age among different populations, data comparison between studies cannot easily be carried out. The interpretation of results is complex because the BMD measurements refer to different age and ethnic groups, and to different techniques used to determine the BMD at various bone sites.…”