Cross‐sectional associations of impaired glucose metabolism measures with bleeding on probing and periodontitis

Abstract

Aim This study assessed the associations of prediabetes and insulin resistance with bleeding on probing (BOP) and periodontitis among adults. Materials and methods We included 1,191 Hispanic adults aged 40-65 years, free of diabetes, enrolled in the San Juan Overweight Adults Longitudinal Study. Pre-diabetes was defined as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or impaired glycated hemoglobin. Impaired one-hour plasma glucose (1hPG) was defined as levels>155 mg/dL. Insulin resistance was defined using the study population-specific 75th percentile (HOMA-IR≥3.13). High BOP was defined as percentage of teeth with bleeding ≥30%. Periodontitis was defined according to the CDC/AAP definition. Results After multivariable adjustment for age, gender, education, smoking status, alcohol consumption, physical activity, obesity, HDL-C, and plaque index, prediabetes with and without 1hPG, IFG, impaired 1hPG, IGT, and HOMA-IR were significantly associated with high BOP; prediabetes, IFG, and impaired 1hPG were significantly associated with severe periodontitis. Most of these associations remained significant when the analyses were restricted to non-smokers. Conclusions This study suggests associations between prediabetes and insulin resistance with BOP and periodontitis. Given the high prevalence of impaired glucose metabolism and periodontitis, the assessment of the temporal sequence of these associations are of utmost importance.

Clinical and radiographic peri‐implant variables around short dental implants in type 2 diabetic, prediabetic, and non‐diabetic patients

“…These findings corroborate with the findings presented by Gomez‐Moreno and colleagues that showed high bleeding tendency in patients with higher HbA1c levels. Another recent cross‐sectional study proved that prediabetic and diabetic states are associated with increased BOP tendency . It is also note‐worthy that mean peri‐implant PD around short implants was statistically significantly higher in T2DM patients as compared to prediabetic and non‐diabetic patients.…”

Involvement of insulin resistance in normoglycaemic obese patients with periodontitis: A cross‐sectional study

“…In short, we observed that IR was significantly associated with the extent of periodontitis, but no differences were observed among patients with respect to the other periodontal variables studied when they were classified by HOMA‐IR. In this sense, a recent study found that HOMA‐IR tends to increase the odds of severe periodontitis, although the association was not significant (Pérez et al., ). Further studies are needed to clarify the role of HOMA‐IR in periodontitis among diabetes‐free participants.…”

Longitudinal association between adiposity and inter‐arm blood pressure difference

“…Supplemental data were also collected in the study to evaluate additional hypotheses formulated before data collection. Recruitment efforts and retention have been previously described . Eligibility criteria for this cohort study included the following: (a) age between 40 and 65 years, (b) overweight or obese (BMI ≥ 25.0 kg/m 2 ), and (c) free of clinically diagnosed diabetes prior to the baseline examination.…”

“…Recruitment efforts and retention have been previously described. 19,20 Eligibility criteria for this cohort study included the following: (a) age between 40 The study consisted of multiracial individuals of Hispanic ethnicity, who reported their race as White (25%), Black (14%), and Mixed (61%). From the 1351 baseline eligible participants, 1028 (76%) came to the 3-year follow-up visit.…”