Cross-Sectional Study of the Prevalence of Radiographic Degenerative Joint Disease in Domesticated Cats

Lascelles, B. Duncan X.; Henry, John B.; Brown, James A.; Robertson, Ian; Sumrell, Andrea Thomson; Simpson, Wendy; Wheeler, S. J.; Hansen, Bernie; Zamprogno, Helia; Freire, Mila; Pease, Anthony P.

doi:10.1111/j.1532-950x.2010.00708.x

Cited by 158 publications

(203 citation statements)

References 15 publications

Supporting

Mentioning

193

Contrasting

Order By: Relevance

“…Cats meeting eligibility criteria were then sedated, and orthogonal radiographs were made of each joint. Radiographs were reviewed for the presence of DJD/OA as described in [53] by a board-certified veterinary radiologist masked to the results of the orthopedic examination.…”

Section: Methodsmentioning

confidence: 99%

The Use of Functional Data Analysis to Evaluate Activity in a Spontaneous Model of Degenerative Joint Disease Associated Pain in Cats

et al. 2017

Self Cite

View full text Add to dashboard Cite

Introduction and objectivesAccelerometry is used as an objective measure of physical activity in humans and veterinary species. In cats, one important use of accelerometry is in the study of therapeutics designed to treat degenerative joint disease (DJD) associated pain, where it serves as the most widely applied objective outcome measure. These analyses have commonly used summary measures, calculating the mean activity per-minute over days and comparing between treatment periods. While this technique has been effective, information about the pattern of activity in cats is lost. In this study, functional data analysis was applied to activity data from client-owned cats with (n = 83) and without (n = 15) DJD. Functional data analysis retains information about the pattern of activity over the 24-hour day, providing insight into activity over time. We hypothesized that 1) cats without DJD would have higher activity counts and intensity of activity than cats with DJD; 2) that activity counts and intensity of activity in cats with DJD would be inversely correlated with total radiographic DJD burden and total orthopedic pain score; and 3) that activity counts and intensity would have a different pattern on weekends versus weekdays.Results and conclusionsResults showed marked inter-cat variability in activity. Cats exhibited a bimodal pattern of activity with a sharp peak in the morning and broader peak in the evening. Results further showed that this pattern was different on weekends than weekdays, with the morning peak being shifted to the right (later). Cats with DJD showed different patterns of activity from cats without DJD, though activity and intensity were not always lower; instead both the peaks and troughs of activity were less extreme than those of the cats without DJD. Functional data analysis provides insight into the pattern of activity in cats, and an alternative method for analyzing accelerometry data that incorporates fluctuations in activity across the day.

show abstract

Section: Methodsmentioning

confidence: 99%

The Use of Functional Data Analysis to Evaluate Activity in a Spontaneous Model of Degenerative Joint Disease Associated Pain in Cats

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…The numbers were randomly ranked using a computer program and the first 25 cats in each age group were selected to come in for a health screen. This yielded a cohort of 100 cats with 25 cats that had been randomly selected in each age group 9. Although selected at random, no cat was acutely ill at the time of data collection.…”

Section: Methodsmentioning

confidence: 99%

Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies

Marino

Lascelles

Vaden

et al. 2013

Journal of Feline Medicine and Surgery

183

151

View full text Add to dashboard Cite

Chronic kidney disease (CKD) and degenerative joint disease are both considered common in older cats. Information on the co-prevalence of these two diseases is lacking. This retrospective study was designed to determine the prevalence of CKD in two cohorts of cats: cats randomly selected from four evenly distributed age groups (RS group) and cats recruited for degenerative joint disease studies (DJD group), and to evaluate the concurrence of CKD and DJD in these cohorts. The RS group was randomly selected from four age groups from 6 months to 20 years, and the DJD group comprised cats recruited to four previous DJD studies, with the DJD group excluding cats with a blood urea nitrogen and/or serum creatinine concentration >20% (the upper end of normal) for two studies and cats with CKD stages 3 and 4 for the other two studies. The prevalence of CKD in the RS and DJD groups was higher than expected at 50% and 68.8%, respectively. CKD was common in cats between 1 and 15 years of age, with a similar prevalence of CKD stages 1 and 2 across age groups in both the RS and DJD cats, respectively. We found significant concurrence between CKD and DJD in cats of all ages, indicating the need for increased screening for CKD when selecting DJD treatments. Additionally, this study offers the idea of a relationship and causal commonality between CKD and DJD owing to the striking concurrence across age groups and life stages.

show abstract

“…In cats, osteoarthritis (OA) develops with aging and causes significant chronic pain expressed as gait abnormalities, decreased activity and various behavioral changes (Bennett and Morton, 2009;Lascelles et al, 2010;Slingerland et al, 2011;Benito et al, 2012;Bennett et al, 2012;Klinck et al, 2012).…”

Section: Introductionmentioning

confidence: 95%

[18F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain

Guillot

Chartrand

Chav

et al. 2015

The Veterinary Journal

View full text Add to dashboard Cite

Cross-Sectional Study of the Prevalence of Radiographic Degenerative Joint Disease in Domesticated Cats

Abstract: DJD is a common disease of domesticated cats that requires further investigation of its associated clinical signs.

Cited by 158 publications

References 15 publications

The Use of Functional Data Analysis to Evaluate Activity in a Spontaneous Model of Degenerative Joint Disease Associated Pain in Cats

The Use of Functional Data Analysis to Evaluate Activity in a Spontaneous Model of Degenerative Joint Disease Associated Pain in Cats

Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies

[18F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain

Contact Info

Product

Resources

About