Cross-sectional Survey of Hantavirus Infection, Brazil

Limongi, Jean Ezequiel; Costa, Fabíola Corrêa da; Pinto, Rogério Melo Costa; Oliveira, Renata Carvalho de; Bragagnolo, Camila; Lemos, Elba Regina Sampaio de; Paula, Márcia Beatriz Cardoso de; Neto, Adalberto A. Pajuaba; Ferreira, Marcelo Simão

doi:10.3201/eid1512.090229

Cited by 18 publications

(19 citation statements)

References 11 publications

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“…The IgG prevalence in this study was lower than that of other regions in Brazil where HCPS is highly endemic, such as 13.6% in the State of Mato Grosso 11 . However, an IgG prevalence of 2% was reported in Uberlandia City in Minas Gerais State 12 , which is another hantavirus-endemic region; this is similar to the prevalence found in the present study. The IgG prevalence found in the present study is in keeping with prevalence rates in other regions where HCPS has not been described, such as in the southern parts of Santa Catarina State (2.3%) 13 , in Ceará State (2.8%) 14 , an in Ilhéus City in Bahia State (0.6%) 15 .…”

supporting

confidence: 80%

First serologic evidence of human hantavirus infection in Alagoas State in Northeastern Brazil

Santos-Júnior

Santos

Barros

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction:Hantavirus cardiopulmonary syndrome (HCPS) is rare in Northeastern Brazil. Methods: Prospective surveillance was conducted over a two-year period in Alagoas State, Northeastern Brazil. The prevalence of anti-hantavirus N-antigen IgM and IgG in human serum samples was determined by enzyme-linked immunosorbent assay testing. Results: High avidity IgG was found in nine of 476 serum samples tested (from 102 patients with clinical manifestations compatible with HCPS, 124 patients with leptospirosis, and 250 healthy rural workers). Conclusions: Serologic evidence of past hantavirus infection in residents of Alagoas State indicates that hantaviruses are present in northeastern Brazil, even in areas silent for HCPS.

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supporting

confidence: 80%

First serologic evidence of human hantavirus infection in Alagoas State in Northeastern Brazil

Santos-Júnior

Santos

Barros

et al. 2017

Rev. Soc. Bras. Med. Trop.

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“…More HCPS cases were reported in Minas Gerais than in any other state in Brazil 10 . Genetic studies associated HCPS cases with hantavirus Araraquara, possibly the most virulent of Brazilian hantaviruses, and identified the wild rodent Necromys lasiurus as a reservoir of this virus 5,15. We recently reported asymptomatic human infections in this area 8 . We have now conducted a serological survey to reveal hantavirus infection in rodents and to further understand its ecoepidemiology in an important endemic area in Minas Gerais, Brazil.…”

Section: Introductionmentioning

confidence: 99%

Serological survey of hantavirus in rodents in Uberlândia, Minas Gerais, Brazil

Limongi

Moreira

Peres

et al. 2013

Rev. Inst. Med. trop. S. Paulo

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SUMMARYWe conducted a serological survey to determine the presence of hantavirus infection in rodents in Uberlândia, Minas Gerais as well as to identify and characterize associated factors. Rodents were captured using Sherman live-capture traps set in rural and periurban environments. A total of 611 rodents were captured. There was a higher trap success in peri-urban areas (26.3%) and a higher prevalence of antibodies among rodents captured in rural areas (2.9%). Necromys lasiurus was the most common species (42.2%) and the more frequently infected (4.6%). One Calomys tener (1/141; 0.7%) and one Calomys sp. (1/14; 7.1%) were also positive for the hantavirus infection. In N. lasiurus, antibody prevalence correlated with population density (p < 0.01), age class (p = 0.003) and presence of scars (p = 0.02). The data confirm that horizontal transmission is the main mechanism that maintains the virus in nature. The higher seropositivity in N. lasiurus is consistent with genetic studies that associate this species with an Araraquara virus reservoir; the seropositivity of C. tener and Calomys sp. may indicate the occurrence of spillover infection or the presence of other circulating hantaviruses.

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“…n the Americas, hantavirus species that occur at low frequency are associated with the severe disease hantavirus pulmonary syndrome (HPS) (1,2), and species that occur at higher frequency are associated with milder disease (3)(4)(5). In Panama, HPS is caused by the Choclo virus, for which a common rodent, the fulvous pygmy rice rat (6), is host.…”

mentioning

confidence: 99%