Cross-species transcriptomic signatures identify mechanisms related to species sensitivity and common responses to nanomaterials

Nanobiology Dependent Therapeutic Convergence between Biocompatibility and Bioeffectiveness of Graphene Oxide Quantum Dot Scaffold for Immuno‐Inductive Angiogenesis and Nerve Regeneration

“…For implantable nerve tissue engineering products, it was essential to ensure their biocompatibility in vivo. [ 33 ] First, we used pathophysiological ways to study the morphology of major organs harvested from rats that received 4‐months implantation. We observed no significant abnormality in heart, liver, spleen, lung, kidney, brain, and dorsal root ganglion (Figure 6k; Figure S10, Supporting Information).…”

Predicting the phytotoxic mechanism of action of LiCoO2 nanomaterials using a novel multiplexed algal cytological imaging (MACI) assay and machine learning

“…This would makes sense as LCO tends to target proteins and pathways that are involved in transport of electrons. 7,6 Predicting the MoA of individual LCO-treated cells using convolutional neural networks In addition to the hierarchical clustering analysis, a convolutional neural network was also used to classify individual LCO-treated cells into mechanistic classes. In CellProfiler Analyst, a CNN was trained on a small subset of randomly fetched cells from each treatment (∼9.3% of cells from the combined LCO and reference chemical exposures) using 50 × 50 neurons per layer.…”

“…Current research has been done to assess LCO's toxicological impacts and mechanism of action (MoA) in higher animal-type organisms. For example, Curtis et al , 2022 6 has reported LCO to cause a differential expression in electron transport and energy metabolism related genes across different fish and invertebrate species. Furthermore, Niemuth et al , 2020 7 has reported LCO to participate in redox reactions and alter the redox state of and Fe–S proteins, which are important for electron transport.…”

On biosafety of Sn-containing halide perovskites

“…As suggested by the US National Academy of Sciences, 42 the predictive, mechanistic, and quantitative characterization which provide more insight for the toxicity assessment are preferred when considering a material's biological impact. Therefore, RNA sequencing (RNA Seq), [43][44][45][46][47] which can determine the global gene expression profiling and yield high throughput screening and high-volume data production, was utilized to uncover the mechanism of biological interaction of tin containing halide perovskites and SnI 2 . RNA sequencing also provides a useful and powerful tool to assess the health risk of tin containing halide perovskites and SnI 2 at the gene level, which is inaccessible using traditional methods.…”