Cross Talk of Macrophages with Tumor Microenvironment Cells and Modulation of Macrophages in Cancer by Virotherapy

Somma, Sarah Di; Napolitano, Fabiana; Portella, Giuseppe; Malfitano, Anna Maria

doi:10.3390/biomedicines9101309

Cited by 7 publications

(6 citation statements)

References 55 publications

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“…Crosstalk between macrophages and tumor cells via cell‐cell contact or via secreted factors remodels the CRC microenvironment. [ 23 ] Our data derived under lactic acidosis conditions suggests that secreted factors (including lactic acid) from cancer cells may shape macrophage polarization status. To test whether NAMPT is involved in the polarization of TAMs caused by the interplay with tumor cells, we co‐cultured tumor cells with macrophages.…”

Section: Resultsmentioning

confidence: 98%

NAMPT‐Driven M2 Polarization of Tumor‐Associated Macrophages Leads to an Immunosuppressive Microenvironment in Colorectal Cancer

Hong,

Lee,

Kim

et al. 2024

Advanced Science

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Nicotinamide phosphoribosyltransferase (NAMPT) is a metabolic enzyme with key roles in inflammation. Previous studies have examined the consequences of its upregulated expression in cancer cells themselves, but studies are limited with respect to its role in the other cells within the tumor microenvironment (TME) during colorectal cancer (CRC) progression. Using single‐cell RNA sequencing (scRNA‐seq) data, it is founded that NAMPT is highly expressed in SPP1+ tumor‐associated macrophages (TAMs), a unique subset of TAMs associated with immunosuppressive activity. A NAMPThigh gene signature in SPP1+ TAMs correlated with worse prognostic outcomes in CRC patients. The effect of Nampt deletion in the myeloid compartment of mice during CRC development is explored. NAMPT deficiency in macrophages resulted in HIF‐1α destabilization, leading to reduction in M2‐like TAM polarization. NAMPT deficiency caused significant decreases in the efferocytosis activity of macrophages, which enhanced STING signaling and the induction of type I IFN‐response genes. Expression of these genes contributed to anti‐tumoral immunity via potentiation of cytotoxic T cell activity in the TME. Overall, these findings suggest that NAMPT‐initiated TAM‐specific genes can be useful in predicting poor CRC patient outcomes; strategies aimed at targeting NAMPT may provide a promising therapeutic approach for building an immunostimulatory TME in CRC progression.

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Section: Resultsmentioning

confidence: 98%

NAMPT‐Driven M2 Polarization of Tumor‐Associated Macrophages Leads to an Immunosuppressive Microenvironment in Colorectal Cancer

Hong,

Lee,

Kim

et al. 2024

Advanced Science

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“… 25 Macrophages constitute more than 50% of the tumor mass in solid tumors, while tumor-associated macrophages (TAMs) can originate from both local and circulating progenitor monocytes. 26 TAMs participate in the formation of the tumor microenvironment and play a major role in the TME functions. 27 Inside the TME, cancer cells use various substances such as IL-10, CCL2/3/4/5/7/8, VEGF, CXCL12, and the platelet-derived growth factor (PDGF), to transform type 1 macrophages (M1) into type 2 macrophages (M2).…”

Section: Where Do We Stand In Cancer Immunotherapeutics?mentioning

confidence: 99%

How Advanced are Cancer Immuno-Nanotherapeutics? A Comprehensive Review of the Literature

Yadav¹,

Puranik²,

Meshram³

et al. 2023

IJN

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Cancer is a broad term for a group of diseases involving uncontrolled cell growth and proliferation. There is no cure for cancer despite recent significant improvements in screening, treatment, and prevention approaches. Among the available treatments, immunotherapy has been successful in targeting and killing cancer cells by stimulating or enhancing the body's immune system. Antibody-based immunotherapeutic agents that block immune checkpoint proteins expressed by cancer cells have shown promising results. The rapid development of nanotechnology has contributed to improving the effectiveness and reducing the adverse effects of these anti-cancer immunotherapeutic agents. Recently, engineered nanomaterials have been the focus of many state-of-The-art approaches toward effective cancer treatment. In this review, the contribution of various nanomaterials such as polymeric nanoparticles, dendrimers, microspheres, and carbon nanomaterials in improving the efficiency of anti-cancer immunotherapy is discussed as well as nanostructures applied to combination cancer immunotherapy.

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“…Anti-tumor macrophages (also called M1 macrophages) recruits CD8+ T-cells to fight the tumor 32 , explaining its appearance in the IE group where we expect to have higher anti-tumor to pro-tumor macrophage ratio 31 . On the contrary, pro-tumor macrophages (also called M2 macrophages) are known to conspire with CAFs to boost tumor malignancy 33,34 , motivating why this interaction appears in the most hostile immune phenotype. Overall, these considerations show that the network features are able to capture general characteristics of immune phenotypes well and show potential to distinguish the functional role of cell-types based on their interactions.…”

Section: Pan-cancer Analysismentioning

confidence: 99%

Mathematically mapping the network of cells in the tumor microenvironment

Santvoort

Lapuente-Santana

Finotello

et al. 2023

Preprint

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Cell-cell interaction networks are pivotal in cancer development and treatment response. These networks can be inferred from data, however this process often combines data from multiple patients, and/or creates networks on a cell-types level. It creates a good average overview of cell-cell interaction networks, but fails to capture patient heterogeneity and/or masks potentially relevant local network structures. We propose a mathematical model based on random graphs (called RaCInG) to alleviate these issues using prior knowledge on potential cellular interactions and patient's bulk RNA-seq data. We have applied RaCInG to extract 444 network features related to the tumor microenvironment, unveiled associations with immune response and subtypes, and identified cancer-type specific differences in inter-cellular signaling. Additionally, we have used RaCInG to explain how immune phenotypes regulated by context-specific intercellular communication affect immunotherapy response. RaCInG is a modular pipeline, and we envision its application for cell-cell interaction reconstruction in different contexts.

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Cross Talk of Macrophages with Tumor Microenvironment Cells and Modulation of Macrophages in Cancer by Virotherapy

Cited by 7 publications

References 55 publications

NAMPT‐Driven M2 Polarization of Tumor‐Associated Macrophages Leads to an Immunosuppressive Microenvironment in Colorectal Cancer

NAMPT‐Driven M2 Polarization of Tumor‐Associated Macrophages Leads to an Immunosuppressive Microenvironment in Colorectal Cancer

How Advanced are Cancer Immuno-Nanotherapeutics? A Comprehensive Review of the Literature

Mathematically mapping the network of cells in the tumor microenvironment

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